Exosomes Based Drug Delivery Strategies for Brain Disorders

本書全面介紹了外泌體在腦部疾病中的作用，包括中風、多發性硬化症、帕金森氏症、阿茲海默症、癲癇和憂鬱症。它涵蓋了外泌體生成、組成和合成的基礎知識，以及外泌體在腦部疾病治療中的潛力。本書詳細介紹了外泌體與神經炎症的相關性，使用外泌體作為新型載體的挑戰，以及工程化外泌體用於傳遞治療蛋白質的方法。本書還介紹了使用放射標記的外泌體作為診斷工具，以及外泌體的毒性研究和潛在的克服方法。對於從事外泌體研究，特別是在腦部疾病應用方面的研究人員、臨床醫生和醫療專業人員來說，這是一本必不可少的資源。

Dr. Neeraj Mishra is working as Professor in Amity Institute of Pharmacy, Gwalior since July 2019. He has around twenty years of teaching and research experience. He was recipient of ICMR- SRF (New Delhi, India). He worked as brand ambassador of Bentham Science, USA 2018-19. He has guided thirty M Pharm students and guided one Ph.D. student. He has more than 100 publications of International and National repute in recent concepts of novel drug delivery systems, Oral delivery of Synbiotics, localized drug delivery, targeted and controlled drug delivery of nanocarriers/ microparticles for the treatment of breast, colon cancer, and neurodegenerative disorders. Dr. Mishra more than 3200 citations with h- index 29. The total cumulative Impact Factor of his published papers is more than 300 (as per SCOPUS). He has also written more 15 Books and 25 book chapters in Elsevier, Bentham, Springer and Wiley Publication etc. He has also been granted 3 international patents and 3 Indian patents. Dr. Mishra is recipient of "Distinguished Professor Award" 2019 from DST-NSTMIS, SPAICS, Indore, and M.P. in September 2019. Dr. Mishra has also received the "Outstanding Scientist Award; 2020, 6th International. Scientist Awards on Engineering, Science, and Medicine, 20-21 June 2020, Chennai, India. Dr. Mishra has received the "Distinguished Professor Award; 2021 from Indian Pharmaceutical Association, MP State Branch, Indore. Dr. Mishra has received "Best Academician Award" in the Indian Pharmacy Graduate Association, M.P. State International Conference held on 06th May 2023 at DAVV Auditorium, Indore, India. He is also received one MPCST Project entitled "Dual functional colon- targeted tofacitinib and probiotics loaded microparticles for the treatment of Inflammatory Bowel Disease.

Sumel Ashique has been working as an assistant professor in Pandaveswar School of Pharmacy, West Bengal, India. He has 3 years of teaching experience. He has achieved 50+ publications of International and national accredited reputed journals (Scopus, UGC). He has knowledge in drug delivery, nanotechnology and targeted treatment strategy. He has also 4 granted patents from IP and Australia, 6 published book chapters in International Books and 12 book chapters have been submitted to well-known publishers like Springer, Elsevier, Bentham and Taylor & Francis. Currently he is editing 5 books under CRC Press, Taylor and Francis, wiley and springer.

Dr. Ashish Garg is working as Professor in Guru Ramdas Khalsa Institute of Science and Technology (Pharmacy), Jabalpur, M.P. He has around ten years of teaching and research experience. He has 80 publications in National and International journals of repute. He is an author of 27 book chapters and edited a few books on recent concepts of nanotechnology, novel drug delivery systems, cancer targeting etc. Dr. Ashish Garg has granted 3 international patents and published 3 Indian patents. He also acts as editorial board member and reviewer in various journals.

Dr. Vadivalagan Chithravel is a postdoctoral research fellow (NIH, USA Project) at the University of Michigan, since2023. His study focuses on Exosomal transduction signals via miRNAs and cfDNAs and he has experience in the fields of molecular biology and biochemistry. In 2013, the Bharathiar University conferred on him a doctorate in Animal Biotechnology. He worked with SAARP Foundation as a Scientist and Group Leader, and from October 2012 to September 2019 his research helped the organization's Vector Borne Disease Control Program. Thereafter, from December 2019 to July 2021, he worked as a Postdoctoral Research Fellow at Taipei Medical University's Graduate Institute of Medical Science, where his research focused on circulating miRNAs and exosomal biomarkers for cellular physiology. Furthermore, he employed as an assistant professor of medicine at AKFA University from September 2021 to June 2022. His study focused on the regulation of metabolic disease via exosome-mediated miRNA delivery. Afterwards, he joined the China Medical University as a postdoctoral fellow during Aug 2022 to March 2023 and dealt on molecular cell signaling and drug toxicity. Dr. Vadivalagan now has a wide range of scientific contributions in the fields of molecular biology and biochemistry. Additionally, COI, a candidate gene for Species Identification, was assigned a 188 GenBank and 30 BOLD accession number. He has received multiple prestigious awards, including National Fellow for Ph.D. research (UGC National Fellow 2009-2012, India), Young Scientist Award (International Society of Zoological Science 2010, ISZS-China), Technology Talante Postdoctoral Fellow (MOST (NSTC) Taiwan 2019-2021), and Technology Talent Postdoctoral Fellow (MOST (NSTC) Taiwan 2022-2023).

Dr. Krishnan Anand is working assenior lecturer in University of the Free State, South Africa since September 2022. He has expertise in organic chemistry/medical biochemistry/ integrative medicine/nano (bio) technology/drug discovery. He received his doctoral degree in organic chemistry in the Department of Chemistry, Durban University of Technology, in collaboration with the Department of Medical Biochemistry, University of KwaZulu-Natal, in 2014. He completed his master's degree in organic chemistry from Bharathiar University, India, and bachelor's degree in chemistry from Madurai Kamaraj University, India. He was Postdoctoral Researcher at Durban University of Technology, South Africa, from November 2014 to November 2016. Later, He worked as a Senior Researcher in the Discipline of Medical Biochemistry and Chemical Pathology, School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa from January 2017 to June 2019. He was recognized for his contributions and received awards from national and international organizations, including, best postdoctoral researcher Award for 2016 and 2017 from Durban University of Technology and Young Scientist Researcher Award 2016 from Pearl Foundation. He was evaluated by the National Research Foundation and was awarded a Y1 rating which is given to promising young researchers. In the latest list published by Stanford University, Dr Krishnan Anand was named in the Top 2% of the most influential scientists worldwide.

Dr. Neeraj Mishra自2019年7月起在Amity Institute of Pharmacy, Gwalior擔任教授。他擁有約二十年的教學和研究經驗。他曾獲得印度國家醫學研究委員會(ICMR)的研究獎學金。他曾擔任Bentham Science的品牌大使(2018-19年)。他指導了三十名藥學碩士研究生和一名博士研究生。他在國際和國內知名期刊上發表了100多篇關於新型藥物傳遞系統、口服益生菌的傳遞、局部藥物傳遞、靶向和控制針對乳腺癌、結腸癌和神經退行性疾病的納米載體/微粒的治療的論文。Mishra博士的論文被引用超過3200次，h指數為29。根據SCOPUS的統計，他發表的論文的總累計影響因子超過300。他還在Elsevier、Bentham、Springer和Wiley等出版社出版了15本書和25個章節。他還獲得了3項國際專利和3項印度專利。Mishra博士於2019年9月獲得了來自DST-NSTMIS、SPAICS、Indore和M.P.的“傑出教授獎”。Mishra博士還於2020年6月20日至21日在印度金奈舉辦的第六屆國際科學家工程、科學和醫學獎項上獲得了“傑出科學家獎”。Mishra博士還於2021年獲得了印度藥學協會MP分會Indore的“傑出教授獎”。Mishra博士還在2023年5月6日在印度Indore的DAVV禮堂舉辦的印度藥學研究生協會MP分會國際會議上獲得了“最佳學者獎”。他還獲得了一項MPCST項目，該項目名為“用於治療炎症性腸病的雙功能結腸靶向托法替尼和益生菌載體微粒”。

Sumel Ashique在印度西孟加拉邦的Pandaveswar School of Pharmacy擔任助理教授。他有3年的教學經驗。他在國際和國內知名期刊(Scopus、UGC)上發表了50多篇論文。他在藥物傳遞、納米技術和靶向治療策略方面有專業知識。他還獲得了4項IP和澳大利亞的專利，發表了6個國際書籍章節，並提交了12個章節給Springer、Elsevier、Bentham和Taylor & Francis等知名出版社。目前，他正在CRC Press、Taylor and Francis、Wiley和Springer等出版社編輯5本書。

Dr. Ashish Garg在印度Jabalpur的Guru Ramdas Khalsa Institute of Science and Technology (Pharmacy)擔任教授。他擁有約十年的教學和研究經驗。他在國內外知名期刊上發表了80篇論文。他是27本書的作者，並編輯了幾本關於納米技術、新型藥物傳遞系統、癌症靶向等最新概念的書籍。Ashish Garg博士獲得了3項國際專利和3項印度專利。他還擔任各種期刊的編輯委員會成員和審稿人。

Dr. Vadivalagan Chithravel是密歇根大學的博士後研究員(美國國立衛生研究院(NIH)項目)，自2023年起在該大學工作。他的研究專注於miRNA和cfDNA通過外泌體傳遞的訊號，並在分子生物學和生物化學領域有經驗。2013年，他獲得了巴拉蒂亞爾大學動物生物技術博士學位。他曾在SAARP基金會擔任科學家和團隊負責人，從2012年10月到2019年9月，他的研究幫助了該組織的傳媒傳染病控制計劃。此後，從2019年12月到2021年7月，他在台北醫學大學醫學科學研究所擔任博士後研究員，他的研究重點是循環miRNA和外泌體生物標記物在細胞生理學中的應用。此外，他還擔任助理教授。