Metal Toxicology Handbook
暫譯: 金屬毒理學手冊

重金屬和類金屬，單獨或結合使用，會通過急性或慢性病理引發毒性表現。特別是，長期接觸各種重金屬和類金屬對人類和動物可能導致多種身體、肌肉、神經、腎臟及各種退化性疾病和功能障礙，包括多發性硬化症、肌肉萎縮症、帕金森病和阿茲海默病、心血管疾病等。

已知的重金屬如鉛、汞、砷、鎘、銻和六價鉻以其極高的毒性而聞名。急性重金屬暴露的即時生命體徵包括噁心、嘔吐、腹瀉和急性腹痛。汞被認定為最具毒性的重金屬，汞中毒被稱為肢端痛或粉紅病。同樣，鉛作為另一種有毒重金屬，曾經是油漆的重要成分。

《金屬毒理學手冊》進一步解釋和討論金屬的各種特性，探討毒性、安全性以及金屬的正確人類利用。該書從金屬、類金屬、氧化還原生物學和神經退化的廣泛概述開始，然後深入探討金屬的角色、益處和毒性，每個部分包含28章來自各自領域的著名研究者和科學家的貢獻，是任何研究金屬潛在毒性的人必備的參考書。

主要特點：
- 討論金屬毒性的病理
- 突出金屬的益處
- 解釋恢復代謝穩態的機制和顯著特徵
- 突出釩的安全性和毒性的劑量依賴性有益和不良影響

初始介紹部分提供了金屬、類金屬、氧化還原生物學和神經退化的廣泛概述。第二部分在兩章中討論金屬毒性的病理，而第三部分在兩章中突出恢復代謝穩態的機制和顯著特徵。第四部分展示了放射性核素的毒性。第五部分則以不同的節奏討論金屬的益處，共四章。第六部分標題為「各種重金屬和類金屬引起的毒性表現」，提供十四章討論各個金屬的毒理機制和表現。

編輯們撰寫了一篇名為「金屬毒性論文」的評論，總結了金屬毒性及其後果的生動情景。

Debasis Bagchi, PhD, MACN, CNS, MAIChE, received his PhD in medicinal chemistry in 1982. He is the Director of Scientific Affairs, VNI, Inc., Lederach, Pennsylvania; an Adjunct Faculty at Texas Southern University, Houston, Texas and a past Faculty in the Department of Pharmacological and Pharmaceutical Sciences at the University of Houston College of Pharmacy, Houston, Texas. He served as the Chief Scientific Officer at Cepham, Inc., Belmont, New Jersey, from June 2013 through December 2018. He was the Senior Vice President of Research and Development of InterHealth Nutraceuticals, Inc., Benicia, California, from 1998 until February 2011, and then as the Director of Innovation and Clinical Affairs of Iovate Health Sciences, Oakville, Ontario, Canada, until June 2013. Dr Bagchi received the Master of American College of Nutrition Award in October 2010. He is the Past Chairman of International Society of Nutraceuticals and Functional Foods (ISNFF), Past President of American College of Nutrition, Clearwater, Florida, and Past Chair of the Nutraceuticals and Functional Foods Division of Institute of Food Technologists (IFT), Chicago, Illinois. He is serving as a Distinguished Advisor at the Japanese Institute for Health Food Standards (JIHFS), Tokyo, Japan. He is a Member of the Study Section and Peer Review Committee of the National Institutes of Health (NIH), Bethesda, Maryland. He has published 372 papers in peer-reviewed journals, has written 41 books, and has 20 patents. He is also a Member of the Society of Toxicology, Member of the New York Academy of Sciences, Fellow of the Nutrition Research Academy, and Member of the TCE stakeholder Committee of the Wright-Patterson Air Force Base, Ohio. He is the Associate Editor of the Journal of Functional Foods, Journal of the American College of Nutrition, and Archives of Medical and Biomedical Research, and he also serves as an Editorial Board Member of numerous peer-reviewed journals, including Antioxidants and Redox Signaling, Cancer Letters, Food and Nutrition Research, Toxicology Mechanisms and Methods, The Original Internist, and other peer-reviewed journals.

Manashi Bagchi, PhD, FACN, received her PhD in chemistry in 1984. She is currently the Chief Scientific Officer of Dr. Herbs LLC, Concord, California. She is also a Consultant for VNI, Lederach, Pennsylvania. She served as an Associate Professor at the Creighton University School of Pharmacy and Allied Health Profession, Omaha, Nebraska, from September 1990 until August 1999. Later, she served as the Director of Research at InterHealth Nutraceuticals, Benicia, California, from September 1999 to July 2009. She is a Member of the Study Section and Peer Review Committee of the National Institutes of Health (NIH), Bethesda, Maryland. Her research interests include free radicals, human diseases, toxicology, carcinogenesis, anti-aging and anti-inflammatory pathophysiology, mechanistic aspects of cytoprotection by antioxidants and chemoprotectants, regulatory pathways in obesity and gene expression, diabetes, arthritis, and efficacy and safety of natural botanical products and dietary supplements. She is a Member of the Society of Toxicology (Reston, Virginia), the New York Academy of Sciences (New York, New York), and the Institutes of Food Technologists (Chicago, Illinois). She is a Fellow and currently Board Member of the American College of Nutrition (Clearwater, Florida). She has published 225 papers in peer-reviewed journals and 2 books, Genomics, Proteomics and Metabolomics in Nutraceuticals and Functional Foods and Bio-Nanotechnology: A Revolution in Food, Biomedical and Health Sciences, from Wiley-Blackwell. She has delivered invited lectures at various national and international scientific conferences and organized workshops and group discussion sessions. She serves as an Editorial Board Member of the Journal of the American College of Nutrition, and is a reviewer of many peer-reviewed journals. She received funding from various institutions and agencies, including the U.S. Air Force Office of Scientific Research, the National Institute of Aging, the Nebraska State Department of Health, and the Cancer Society of Nebraska.

Both Dr. D. Bagchi and Dr. M. Bagchi have extensively researched diverse heavy metals and metalloids, including cadmium, chromium(III), chromium(VI), arsenic, nickel, platinum, zinc, vanadium, manganese, magnesium, bismuth, cobalt, calcium, potassium, iron, and silver since 1993 to demonstrate the diverse molecular mechanisms of toxicity as well as to explore the beneficial effects of selected metals on human health. They have published approximately 75 peer-reviewed publications and book chapters as author or co-author. Their research studies have been supported by the Biomedical Research Support Grant (BRSG), the U.S. Air Force Office of Scientific Research (AFOSR), the National Institutes of Health (NIH), the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID), the Nebraska State Department of Health, and the Procter and Gamble Company (P&G).

Debasis Bagchi博士，MACN，CNS，MAIChE，於1982年獲得藥物化學博士學位。他是位於賓夕法尼亞州Lederach的VNI, Inc.科學事務總監；德克薩斯州休士頓德克薩斯南方大學的兼任教員，以及休士頓大學藥學院藥理學與藥學科的前任教員。他於2013年6月至2018年12月擔任Cepham, Inc.（新澤西州Belmont）的首席科學官。他從1998年到2011年2月擔任InterHealth Nutraceuticals, Inc.（加州Benicia）的研究與開發高級副總裁，隨後擔任Iovate Health Sciences（加拿大安大略省Oakville）的創新與臨床事務總監，直到2013年6月。Bagchi博士於2010年10月獲得美國營養學院大獎。他曾擔任國際營養補充品與功能性食品學會（ISNFF）主席、美國營養學院（佛羅里達州Clearwater）前任會長，以及食品技術學會（IFT）（伊利諾伊州芝加哥）營養補充品與功能性食品部門的前任主席。他目前擔任日本健康食品標準研究所（JIHFS）（日本東京）的特聘顧問。他是美國國立衛生研究院（NIH）（馬里蘭州Bethesda）研究小組及同行評審委員會的成員。他在同行評審期刊上發表了372篇論文，撰寫了41本書籍，並擁有20項專利。他還是毒理學會的成員、紐約科學院的成員、營養研究學院的院士，以及俄亥俄州Wright-Patterson空軍基地的TCE利益相關者委員會成員。他是Journal of Functional Foods、Journal of the American College of Nutrition和Archives of Medical and Biomedical Research的副編輯，並擔任多本同行評審期刊的編輯委員會成員，包括Antioxidants and Redox Signaling、Cancer Letters、Food and Nutrition Research、Toxicology Mechanisms and Methods、The Original Internist及其他同行評審期刊。

Manashi Bagchi博士，FACN，於1984年獲得化學博士學位。她目前是位於加州Concord的Dr. Herbs LLC的首席科學官。她同時也是VNI（賓夕法尼亞州Lederach）的顧問。她曾於1990年9月至1999年8月擔任克雷頓大學藥學與聯合健康專業學院的副教授，隨後於1999年9月至2009年7月擔任InterHealth Nutraceuticals（加州Benicia）的研究總監。她是美國國立衛生研究院（NIH）（馬里蘭州Bethesda）研究小組及同行評審委員會的成員。她的研究興趣包括自由基、人類疾病、毒理學、致癌作用、抗衰老和抗發炎病理生理學、抗氧化劑和化學保護劑的細胞保護機制、肥胖和基因表達的調控途徑、糖尿病、關節炎，以及天然植物產品和膳食補充劑的功效與安全性。她是毒理學會（維吉尼亞州Reston）、紐約科學院（紐約市）和食品技術學會（伊利諾伊州芝加哥）的成員。她是美國營養學院（佛羅里達州Clearwater）的院士及現任董事會成員。她在同行評審期刊上發表了225篇論文和2本書籍，分別是Genomics, Proteomics and Metabolomics in Nutraceuticals and Functional Foods和Bio-Nanotechnology: A Revolution in Food, Biomedical and Health Sciences，由Wiley-Blackwell出版。她在各種國內外科學會議上發表過邀請演講，並組織過工作坊和小組討論會。她是Journal of the American College of Nutrition的編輯委員會成員，並擔任多本同行評審期刊的審稿人。她獲得來自各種機構和機構的資助，包括美國空軍科學研究辦公室、國立老化研究所、內布拉斯加州衛生部和內布拉斯加癌症協會。

自1993年以來，Bagchi博士和Bagchi博士夫婦廣泛研究了多種重金屬和類金屬，包括鎘、鉻(III)、鉻(VI)、砷、鎳、鉑、鋅、釩、錳、鎂、鉍、鈷、鈣、鉀、鐵和銀，以展示多樣的毒性分子機制，並探索選定金屬對人類健康的有益影響。他們作為作者或共同作者發表了約75篇同行評審的出版物和書籍章節。他們的研究得到了生物醫學研究支持補助金（BRSG）、美國空軍科學研究辦公室（AFOSR）、國立衛生研究院（NIH）、美國陸軍傳染病醫學研究所（USAMRIID）、內布拉斯加州衛生部和寶潔公司（P&G）的支持。