Microglia: Physiology, Pathophysiology and Therapeutic Potential
暫譯: 小膠質細胞：生理學、病理生理學與治療潛力

Tremblay, Marie-Ève, Verkhratsky, Alexei

Microglia: Physiology, Pathophysiology and Therapeutic Potential
  • 出版商: Springer
  • 出版日期: 2024-08-30
  • 售價: $11,420
  • 貴賓價: 9.5 折 $10,849
  • 語言: 英文
  • 頁數: 712
  • 裝訂: Hardcover - also called cloth, retail trade, or trade
  • ISBN: 3031555287
  • ISBN-13: 9783031555282

    • 海外代購書籍(需單獨結帳)

商品描述

The past decade has witnessed a revolution in our understanding of microglia, especially since their roles in the healthy CNS have started to unravel. These cells were shown to actively maintain health, in concert with neurons and other types of CNS cells, providing further insight into their crucial involvement with diseases. Edited by Drs. Marie-Ève Tremblay and Alexei Verkhratsky, Microglia: Physiology, Pathophysiology and Therapeutic Potential shares with the scientific and medical community the latest discoveries in the microglial research field, with a truly comprehensive collection of chapters written by the top specialists across five continents. The book begins by explaining briefly what they are, from both historical and evolutionary points of view, and how they can be studied. The first section explains their physiological roles in the maturation, function, and plasticity of the CNS. The second section focuses on their general involvement in neuropathophysiology, and the third section on their critical implication in specific CNS diseases, including neurotrauma, neuropathic pain, ischemia and stroke, infectious diseases, autoimmune diseases, neurodevelopmental and neuropsychiatric disorders, substance use and addiction, sleep disorders, ageing, and neurodegenerative diseases. The fourth section presents their clinical potential as a targeted therapeutic tool for these CNS diseases.

商品描述(中文翻譯)

過去十年見證了我們對小膠質細胞（microglia）理解的革命，特別是自從它們在健康中樞神經系統（CNS）中的角色開始被揭示以來。研究顯示，這些細胞與神經元及其他類型的中樞神經系統細胞共同積極維持健康，進一步深入了解它們在疾病中的關鍵參與。由Marie-Ève Tremblay博士和Alexei Verkhratsky博士編輯的《Microglia: Physiology, Pathophysiology and Therapeutic Potential》與科學和醫學界分享了小膠質細胞研究領域的最新發現，並由來自五大洲的頂尖專家撰寫的章節組成了一個真正全面的合集。本書首先從歷史和進化的角度簡要解釋了小膠質細胞是什麼，以及如何進行研究。第一部分解釋了它們在中樞神經系統的成熟、功能和可塑性中的生理角色。第二部分專注於它們在神經病理生理學中的一般參與，第三部分則探討它們在特定中樞神經系統疾病中的關鍵影響，包括神經創傷、神經性疼痛、缺血和中風、傳染病、自身免疫疾病、神經發展和神經精神疾病、物質使用和成癮、睡眠障礙、老化以及神經退行性疾病。第四部分介紹了它們作為針對這些中樞神經系統疾病的治療工具的臨床潛力。

作者簡介

Marie-Eve Tremblay, Ph.D. is a Canada Research Chair (Tier II) in Neurobiology of Aging and Cognition, and an Associate Professor in the Division of Medical Sciences at the University of Victoria in Victoria, Canada. Her research findings have stimulated the development of a totally new field of research investigating the roles of microglia in the healthy brain.

Alexei Verkhratsky, MD, Ph.D., DSc. is Professor of Neurophysiology in the Faculty of Biology, Medicine and Health at The University of Manchester in Manchester, England. Alexei Verkhratsky is an internationally recognized scholar in the field of cellular neurophysiology, best known for his contributions to our knowledge of the physiology and pathophysiology of neuroglia.

作者簡介(中文翻譯)

Marie-Eve Tremblay 博士是加拿大維多利亞大學醫學科學系的老化與認知神經生物學加拿大研究主席（Tier II）及副教授。她的研究成果促進了一個全新研究領域的發展，探討微膠質細胞在健康大腦中的角色。

Alexei Verkhratsky 醫學博士、哲學博士、科學博士是英國曼徹斯特大學生物、醫學與健康學院的神經生理學教授。Alexei Verkhratsky 是細胞神經生理學領域的國際知名學者，以其對神經膠質細胞生理學和病理生理學的貢獻而聞名。

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