Insights Into Human Neurodegeneration: Lessons Learnt from Drosophila
暫譯: 人類神經退化的洞察：來自果蠅的教訓

本書旨在生成一個更新的科學努力庫，以揭示神經退行性疾病這一複雜而引人入勝的主題。果蠅（*Drosophila* melanogaster）作為模型生物，已被用於研究多種人類神經退行性和神經肌肉疾病超過二十年。果蠅在研究疾病的分子機制方面提供了多種優勢，例如短暫的生命週期、高繁殖數量、低維護成本、簡單而強大的遺傳操作技術、突變體的可用性以及其他遺傳工具，這些都是*Drosophila*作為模型生物的吸引特徵。本書提供了對於從*Drosophila*獲得的經典及最新知識的深入見解，這些知識有助於剖析不同神經退行性疾病的分子機制並揭示新的治療干預範疇。

首先，讀者將了解可用於創建人性化果蠅模型的不同方法，這些模型能真實反映與特定疾病相關的致病性。本書有趣地包括了有關神經幹細胞這一激動人心領域的信息。在詳細描述從*Drosophila*學到的有關阿茲海默症、帕金森症、亨廷頓病、RNA擴展疾病和遺傳性痙攣性截癱病的教訓之前，簡要討論了神經纖維纏結，這是與常見神經退行性疾病相關的特徵表型。不同信號通路在神經退行性疾病中的作用也進行了深入討論。本書最後探討了使用*Drosophila*來識別神經退行性疾病的藥理療法。本書涵蓋的廣泛主題不僅對於對*Drosophila*作為研究人類疾病的廣泛應用概念感到陌生的初學者具有相關性；同時也為科學社群做出貢獻，以有趣且令人驚嘆的方式提供了對我們對神經退行性疾病理解的範式轉變的見解。

Dr. Mousumi Mutsuddi is currently working as a faculty in the Department of Molecular and Human Genetics, Banaras Hindu University, India. She has more than two decades of experience in research and more than a decade of teaching at postgraduate level where she teaches Genetics and Molecular Biology. Dr. Mutsuddi has worked at leading research institutes in India and United States. She has been trained in research at Whitehead Institute of Biomedical Research (2000-2004), Massachusetts Institute of Technology, United States, following which she joined as a Scientist at Broad Institute (2004-2006), Massachusetts Institute of Technology which is a premier biomedical and genomic research center located in Cambridge, Massachusetts, United States. She was also a visiting scientist to Whitehead Institute for Biomedical Research at Massachusetts Institute of Technology (2008) and at National Institute of Health, Bethesda, United States (2012-2013). Her research interest is in the understanding the molecular mechanisms underlying neurodegeneration and neurodevelopment. Dr. Mutsuddi has given lectures on her research findings in several international meetings like Drosophila Research Conference, Chicago, Neuroscience Meeting, Orlando in United States, Human Genetics meeting at Barcelona, Spain and Asia-ARVO etc. She has given invited talks at several places like University of Valencia, Spain, University of Rutgers, Robertwood Johnson Medical School, as well as pharmaceutical companies like Novartis, EnVivo and Celdara Pharmaceuticals. She is also in the editorial board member of several journals as well as in the board of reviewers of many other journals. She has been appointed as an expert for Pre-training Monitoring of companies under Biotechnology Industrial Training Programme (BITP), by Department of Biotechnology, Government of India and was also member of committee for M.Sc in Medical Biotechnology and Molecular and Human Genetics, National Course Curriculum Revision committee organized by Department of Biotechnology, Government of India. Recently she was awarded Visiting Research Faculty position to North Eastern Region by Department of Biotechnology, Government of India in recognition for her outstanding contribution to the field of Biotechnology (2017). She has contributed to more than 40 publications in reputed journals like Current Biology, American Journal of Human Genetics, Genetics, Human Mutation and Journal Neuroscience etc. Dr. Mutsuddi was nominated as one of the six founding member of the Drosophila Board of India as well as elected as member of executive committee for Indian Society of Cell Biology for the period 2013-2015. She is life member of the Indian Society of Developmental Biology, Biotech Research Society of India and has been also nominated as life member of Indian Academy of Neuroscience.

Dr. Ashim Mukherjee is working as a Professor in the Department of Molecular and Human Genetics, Banaras Hindu University, India. He has almost thirty years of research experience in the field of Drosophila Genetics and Molecular Biology. Previously, he has worked as postdoctoral research associate at the University of Massachusetts, Amherst and at the Harvard Medical School, Boston, USA. He has decade-long teaching experience at postgraduate level. His research interest is to decipher the molecular mechanism involved in regulation of Notch signaling. He has identified several novel interacting partners involved in different aspects of Notch signaling. He has published more than 30 papers in renowned journals like Nature Cell Biology, Genome Research, Current Biology, Genetics, Developmental Biology, Cellular Signalling, Journal of Neuroscience etc. Dr. Mukherjee is member of the Drosophila Board of India, life member of Indian Society of Cell Biology and the Indian Society of Developmental Biology. He is also member in the editorial board of several journals and also serves as reviewer for many journals.

穆蘇米·穆茲迪博士目前在印度班納拉斯印度大學的分子與人類遺傳學系任教。她在研究領域擁有超過二十年的經驗，並在研究生階段教授遺傳學和分子生物學，教學經驗超過十年。穆茲迪博士曾在印度和美國的多個頂尖研究機構工作。她在美國麻省理工學院的白海豚生物醫學研究所接受研究訓練（2000-2004），隨後於麻省理工學院的布羅德研究所擔任科學家（2004-2006），該所是位於美國麻薩諸塞州劍橋的頂尖生物醫學和基因組研究中心。她還曾於2008年擔任麻省理工學院白海豚生物醫學研究所的訪問科學家，以及於2012-2013年在美國貝塞斯達的國立衛生研究院擔任訪問科學家。她的研究興趣在於理解神經退行性疾病和神經發展的分子機制。穆茲迪博士在多個國際會議上發表過她的研究成果，如芝加哥的果蠅研究會議、美國奧蘭多的神經科學會議、西班牙巴塞隆納的人類遺傳學會議及亞洲-ARVO等。她在西班牙瓦倫西亞大學、羅格斯大學、羅伯特伍德約翰遜醫學院以及諾華、EnVivo和Celdara Pharmaceuticals等製藥公司發表過受邀演講。她還是多本期刊的編輯委員會成員，以及多本其他期刊的審稿委員。她被印度政府生物技術部任命為生物技術產業培訓計劃（BITP）下公司的預訓練監督專家，並且是由印度政府生物技術部組織的醫學生物技術和分子與人類遺傳學碩士課程修訂委員會的成員。最近，她因在生物技術領域的傑出貢獻而被印度政府生物技術部授予東北地區訪問研究教職的職位（2017年）。她在《當前生物學》、《美國人類遺傳學雜誌》、《遺傳學》、《人類突變》和《神經科學雜誌》等知名期刊上發表了超過40篇論文。穆茲迪博士被提名為印度果蠅委員會的六位創始成員之一，並於2013-2015年期間當選為印度細胞生物學會執行委員會成員。她是印度發育生物學會、生物技術研究學會的終身會員，並被提名為印度神經科學學會的終身會員。

阿希姆·穆克吉博士目前在印度班納拉斯印度大學的分子與人類遺傳學系擔任教授。他在果蠅遺傳學和分子生物學領域擁有近三十年的研究經驗。此前，他曾在美國麻薩諸塞州阿默斯特的麻省大學和波士頓的哈佛醫學院擔任博士後研究助理。他在研究生階段擁有十年的教學經驗。他的研究興趣在於解碼涉及Notch信號調控的分子機制。他已經識別出幾個參與Notch信號不同方面的新型相互作用夥伴。他在《自然細胞生物學》、《基因組研究》、《當前生物學》、《遺傳學》、《發育生物學》、《細胞信號傳導》、《神經科學雜誌》等知名期刊上發表了超過30篇論文。穆克吉博士是印度果蠅委員會的成員，印度細胞生物學會和印度發育生物學會的終身會員。他還是多本期刊的編輯委員會成員，並擔任多本期刊的審稿人。