Microglia: Physiology, Pathophysiology and Therapeutic Potential

Tremblay, Marie-Ève, Verkhratsky, Alexei

Microglia: Physiology, Pathophysiology and Therapeutic Potential
  • 出版商: Springer
  • 出版日期: 2024-08-30
  • 售價: $11,250
  • 貴賓價: 9.5 折 $10,688
  • 語言: 英文
  • 頁數: 712
  • 裝訂: Hardcover - also called cloth, retail trade, or trade
  • ISBN: 3031555287
  • ISBN-13: 9783031555282

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商品描述

The past decade has witnessed a revolution in our understanding of microglia, especially since their roles in the healthy CNS have started to unravel. These cells were shown to actively maintain health, in concert with neurons and other types of CNS cells, providing further insight into their crucial involvement with diseases. Edited by Drs. Marie-Ève Tremblay and Alexei Verkhratsky, Microglia: Physiology, Pathophysiology and Therapeutic Potential shares with the scientific and medical community the latest discoveries in the microglial research field, with a truly comprehensive collection of chapters written by the top specialists across five continents. The book begins by explaining briefly what they are, from both historical and evolutionary points of view, and how they can be studied. The first section explains their physiological roles in the maturation, function, and plasticity of the CNS. The second section focuses on their general involvement in neuropathophysiology, and the third section on their critical implication in specific CNS diseases, including neurotrauma, neuropathic pain, ischemia and stroke, infectious diseases, autoimmune diseases, neurodevelopmental and neuropsychiatric disorders, substance use and addiction, sleep disorders, ageing, and neurodegenerative diseases. The fourth section presents their clinical potential as a targeted therapeutic tool for these CNS diseases.

商品描述(中文翻譯)

過去十年間，我們對於微膠細胞的理解經歷了一場革命，特別是在它們在健康中樞神經系統中的角色開始揭示出來後。這些細胞被證明能夠與神經元和其他類型的中樞神經系統細胞共同維持健康，這進一步揭示了它們在疾病中的重要參與。由Marie-Ève Tremblay博士和Alexei Verkhratsky博士編輯，《微膠細胞：生理學、病理生理學和治療潛力》與科學和醫學界分享了微膠細胞研究領域的最新發現，其中包括由五大洲頂尖專家撰寫的一系列章節。本書首先簡要解釋了微膠細胞的歷史和演化觀點，以及它們的研究方法。第一部分解釋了它們在中樞神經系統的成熟、功能和可塑性中的生理角色。第二部分聚焦於它們在神經病理生理學中的一般參與，第三部分則關注它們在特定中樞神經系統疾病中的重要影響，包括神經創傷、神經病性疼痛、缺血和中風、感染性疾病、自身免疫疾病、神經發育和神經精神障礙、物質濫用和成癮、睡眠障礙、衰老和神經退行性疾病。第四部分介紹了它們作為針對這些中樞神經系統疾病的有針對性治療工具的臨床潛力。

作者簡介

Marie-Eve Tremblay, Ph.D. is a Canada Research Chair (Tier II) in Neurobiology of Aging and Cognition, and an Associate Professor in the Division of Medical Sciences at the University of Victoria in Victoria, Canada. Her research findings have stimulated the development of a totally new field of research investigating the roles of microglia in the healthy brain.

Alexei Verkhratsky, MD, Ph.D., DSc. is Professor of Neurophysiology in the Faculty of Biology, Medicine and Health at The University of Manchester in Manchester, England. Alexei Verkhratsky is an internationally recognized scholar in the field of cellular neurophysiology, best known for his contributions to our knowledge of the physiology and pathophysiology of neuroglia.

作者簡介(中文翻譯)

Marie-Eve Tremblay, Ph.D. 是加拿大維多利亞大學醫學科學部的副教授，同時也是加拿大研究主席（二級）的神經老化和認知神經生物學領域的研究者。她的研究成果促使了一個全新的研究領域的發展，該領域探討了微膠細胞在健康大腦中的作用。

Alexei Verkhratsky, MD, Ph.D., DSc. 是英國曼徹斯特大學生物、醫學和健康學院的神經生理學教授。Alexei Verkhratsky 是在細胞神經生理學領域享有國際聲譽的學者，他最為人所知的是對神經膠細胞的生理學和病理生理學知識的貢獻。

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