Proteoglycans in Stem Cells: From Development to Cancer
暫譯: 幹細胞中的蛋白聚醣：從發展到癌症
Götte, Martin, Forsberg-Nilsson, Karin
- 出版商: Springer
- 出版日期: 2021-06-08
- 售價: $7,920
- 貴賓價: 9.5 折 $7,524
- 語言: 英文
- 頁數: 308
- 裝訂: Hardcover - also called cloth, retail trade, or trade
- ISBN: 3030734528
- ISBN-13: 9783030734527
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商品描述
This book provides a state-of-the-art compendium on the role of proteoglycans and glycosaminoglycans during development and in cancer. It also suggests directions for novel therapeutic and biotechnological applications in stem cell biology.
Proteoglycans and glycosaminoglycans, as part of the extracellular matrix, are multifunctional modulators of growth factor, cytokine, integrin and morphogen signaling, which determine both self-renewal, senescence and/or differentiation of stem cells during development. Since proteoglycans modulate cell adhesion and migration they are important organizers of the extracellular matrix within the proper stem cell niche. A malfunctioning of proteoglycans and glycosaminoglycans contributes to the cancer stem cell phenotype, which is linked to therapeutic resistance and recurrence in malignant disease.
This book is essential reading for anyone interested in the extracellular matrix and its role in development.
The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology.
商品描述(中文翻譯)
本書提供了一部關於蛋白聚醣（proteoglycans）和糖胺聚醣（glycosaminoglycans）在發育及癌症中角色的最先進綜述。它還建議了在幹細胞生物學中，針對新型治療和生技應用的方向。
蛋白聚醣和糖胺聚醣作為細胞外基質的一部分，是生長因子、細胞激素、整合素和形態生成信號的多功能調節因子，這些信號決定了幹細胞在發育過程中的自我更新、衰老和/或分化。由於蛋白聚醣調節細胞黏附和遷移，因此它們在適當的幹細胞生態位中是細胞外基質的重要組織者。蛋白聚醣和糖胺聚醣的功能失常會促成癌症幹細胞表型，這與惡性疾病中的治療抵抗和復發有關。
本書是任何對細胞外基質及其在發育中角色感興趣的讀者必讀的資料。
系列書籍《細胞外基質的生物學》（Biology of Extracellular Matrix）是與美國基質生物學會（American Society for Matrix Biology）合作出版的。
作者簡介
Professor Martin Götte
Martin Götte is a Professor at the Department of Gynecology and Obstetrics at the University of Münster, Germany. He obtained his Ph.D. in Biochemistry at the University of Göttingen/Max-Planck-Institute for Biophysical Chemistry in 1997. Following a postdoctoral training at the Department of Cell Biology of Harvard Medical School, and a group leader position at the Institute of Physiological Chemistry of Münster University in 2000, he holds a tenured position as Head of Research in the Department of Gynecology and Obstetrics since 2003. His main areas of research are the role of Syndecans, Decorin, and glycosaminoglycan biosynthetic enzymes in cancer and inflammation. He is spokesman of the University in the Federal State network for stem cell research and chairman of the board for the reproduction section of the German Society for Endocrinology. He is editorial board member of four Science Citation Index (SCI) listed journals and has authored more than 155 publications.
Professor Karin Forsberg-Nilsson
Karin Forsberg-Nilsson is a Professor of Stem Cell Research at the Department of Immunology, Genetics and Pathology at Uppsala University, Sweden, SciLifeLab Faculty, and Guest Professor at University of Nottingham, UK. She is currently the Dean of the Faculty of Medicine at Uppsala University. Her PhD was obtained in 1992 from Uppsala University she trained as a postdoc at the National Insititutes of Health, US. She held leadership positions in the pharmaceutical industry, and after returning to academia, focused her research on neural stem cells and brain tumors. The goal of her laboratory is an improved treatment of malignant brain tumors. She has served as Deputy Secretary General at the Swedish Research Council, on the Innovative Medicines Initiative Scientific Advisory Board, and as Head of Department. Professor Forsberg-Nilsson is currently on the Board of Directors for the Swedish Fulbright Commission. She is the author of 80 publications in subject areas ranging from growth factors, stem cells, regenerative neurobiology and cancer.
作者簡介(中文翻譯)
馬丁·戈特教授
馬丁·戈特是德國明斯特大學婦產科系的教授。他於1997年在哥廷根大學/馬克斯·普朗克生物物理化學研究所獲得生物化學博士學位。隨後，他在哈佛醫學院細胞生物學系進行了博士後培訓，並於2000年在明斯特大學生理化學研究所擔任小組負責人，自2003年以來，他在婦產科系擔任研究部門負責人的終身職位。他的主要研究領域包括Syndecans、Decorin和糖胺聚糖生物合成酶在癌症和炎症中的作用。他是德國聯邦州幹細胞研究網絡的發言人，也是德國內分泌學會生殖部分的董事會主席。他是四本科學引文索引（SCI）期刊的編輯委員會成員，並已發表超過155篇論文。
卡琳·福斯伯格-尼爾森教授
卡琳·福斯伯格-尼爾森是瑞典烏普薩拉大學免疫學、遺傳學和病理學系的幹細胞研究教授，SciLifeLab教職員，並擔任英國諾丁漢大學的客座教授。她目前是烏普薩拉大學醫學院的院長。她於1992年在烏普薩拉大學獲得博士學位，並在美國國立衛生研究院進行博士後培訓。她曾在製藥行業擔任領導職位，並在回到學術界後，將研究重點放在神經幹細胞和腦腫瘤上。她的實驗室目標是改善惡性腦腫瘤的治療。她曾擔任瑞典研究委員會的副秘書長、創新藥物倡議科學諮詢委員會成員，以及系主任。福斯伯格-尼爾森教授目前是瑞典富布賴特委員會的董事會成員。她在生長因子、幹細胞、再生神經生物學和癌症等領域發表了80篇論文。
