Extracellular Sugar-Based Biopolymers Matrices
暫譯: 細胞外糖基生物聚合物基質
Cohen, Ephraim, Merzendorfer, Hans
- 出版商: Springer
- 出版日期: 2019-07-18
- 售價: $6,250
- 貴賓價: 9.5 折 $5,938
- 語言: 英文
- 頁數: 820
- 裝訂: Hardcover - also called cloth, retail trade, or trade
- ISBN: 3030129187
- ISBN-13: 9783030129187
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商品描述
The extracellular matrix (ECM) is an acellular three-dimensional network composed of proteins, glycoproteins, proteoglycans and exopolysaccharides. It primarily serves as a structural component in the tissues and organs of plants and animals, or forms biofilms in which bacterial cells are embedded. ECMs are highly dynamic structures that undergo continuous remodeling, and disruptions are frequently the result of pathological processes associated with severe diseases such as arteriosclerosis, neurodegenerative illness or cancer. In turn, bacterial biofilms are a source of concern for human health, as they are associated with resistance to antibiotics. Although exopolysaccharides are crucial for ECM formation and function, they have received considerably little attention to date.
The respective chapters of this book comprehensively address such issues, and provide reviews on the structural, biochemical, molecular and biophysical properties of exopolysaccharides. These components are abundantly produced by virtually all taxa including bacteria, algae, plants, fungi, invertebrates and vertebrates. They include long unbranched homopolymers (cellulose, chitin/chitosan), linear copolymers (alginate, agarose), peptoglycans such as murein, heteropolymers like a variety of glycosaminoglycans (hyaluronan, dermatan, keratin, heparin, Pel), and branched heteropolymers such as pectin and hemicellulose.
A separate chapter is dedicated to modern industrial and biomedical applications of exopolysaccharides and polysaccharide-based biocomposites. Their unique chemical, physical and mechanical properties have attracted considerable interest, inspired basic and applied research, and have already been harnessed to form structural biocomposite hybrids for tailor-made applications in regenerative medicine, bioengineering and biosensor design.
Given its scope, this book provides a substantial source of basic and applied information for a wide range of scientists, as well as valuable textbook for graduate and advanced undergraduate students.
商品描述(中文翻譯)
細胞外基質（ECM）是一種由蛋白質、糖蛋白、蛋白聚糖和外多醣組成的無細胞三維網絡。它主要作為植物和動物組織及器官中的結構組件，或形成細菌細胞嵌入的生物膜。ECM 是高度動態的結構，會經歷持續的重塑，且其破壞通常是與動脈硬化、神經退行性疾病或癌症等嚴重疾病相關的病理過程所造成的。反過來，細菌生物膜對人類健康構成了擔憂，因為它們與抗生素的抗藥性有關。儘管外多醣對 ECM 的形成和功能至關重要，但迄今為止，它們卻受到相對較少的關注。
本書的各章節全面探討了這些問題，並提供了外多醣的結構、生化、分子和生物物理特性的綜述。這些成分幾乎由所有類群（包括細菌、藻類、植物、真菌、無脊椎動物和脊椎動物）豐富產生。它們包括長的無分支同聚合物（纖維素、幾丁質/幾丁聚醣）、線性共聚合物（海藻酸鹽、琼脂）、如肽聚糖（肽聚糖）等的聚合物，各種糖胺聚糖（透明質酸、真皮素、角蛋白、肝素、Pel）等的異聚合物，以及如果膠和半纖維素等的分支異聚合物。
有一章專門介紹外多醣和基於多醣的生物複合材料在現代工業和生物醫學中的應用。它們獨特的化學、物理和機械特性引起了相當大的興趣，激發了基礎和應用研究，並已被用來形成結構生物複合材料混合物，以滿足再生醫學、生物工程和生物感測器設計的定制應用。
考慮到其範疇，本書為廣泛的科學家提供了大量的基礎和應用信息，並且是研究生和高年級本科生的寶貴教科書。
作者簡介
Ephraim Cohen is a Professor Emeritus of the Hebrew University of Jerusalem in the discipline of pesticide toxicology. He published a large number of articles and book chapters on the subject of chitin synthesis and inhibition. He is the editor of two volumes (44 and 46) titled "Target Receptors in the Control of Insect Pests" in Advances in Insect Physiology (Academic Press, 2013 and 2014). He is the editor of the recent successful book: "Extracellular Composite Matrices in Arthropods" published by Springer in 2016.
Hans Merzendorfer is appointed as a Professor of Molecular Biology at the University of Siegen, Germany. His research interests are centered on the physiological functions of different membrane proteins including beta-glycosyltransferases involved in the biosynthesis of chitin. He has published about one hundred research articles, reviews, scientific columns and book chapters. He is a current member of the editorial boards of Insect Biochemistry and Molecular Biology and Frontiers in Zoology, and speaker of the section of Physiology of the German Zoological Society.
作者簡介(中文翻譯)
以法拉伊姆·科恩（Ephraim Cohen）是耶路撒冷希伯來大學的榮譽教授，專攻農藥毒理學。他在幾丁質合成及其抑制方面發表了大量的文章和書籍章節。他是《昆蟲生理學進展》（Advances in Insect Physiology）中兩卷（第44卷和第46卷）名為《昆蟲害蟲控制中的靶受體》（Target Receptors in the Control of Insect Pests）的編輯，該書由學術出版社（Academic Press）於2013年和2014年出版。他還是2016年由施普林格（Springer）出版的成功新書《節肢動物的細胞外複合基質》（Extracellular Composite Matrices in Arthropods）的編輯。
漢斯·梅爾岑多夫（Hans Merzendorfer）被任命為德國西根大學的分子生物學教授。他的研究興趣集中在不同膜蛋白的生理功能上，包括參與幾丁質生物合成的β-糖基轉移酶（beta-glycosyltransferases）。他已發表約一百篇研究文章、評論、科學專欄和書籍章節。他目前是《昆蟲生物化學與分子生物學》（Insect Biochemistry and Molecular Biology）和《動物學前沿》（Frontiers in Zoology）編輯委員會的成員，並擔任德國動物學會生理學分會的發言人。
