Multiple Testing Procedures with Applications to Genomics (Springer Series in Statistics)
暫譯: 基因組學中的多重檢定程序(施普林格統計系列)
Sandrine Dudoit, Mark J. van der Laan
- 出版商: Springer
- 出版日期: 2007-12-19
- 售價: $8,670
- 貴賓價: 9.5 折 $8,237
- 語言: 英文
- 頁數: 590
- 裝訂: Hardcover
- ISBN: 0387493166
- ISBN-13: 9780387493169
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相關分類:
機率統計學 Probability-and-statistics
海外代購書籍(需單獨結帳)
商品描述
This book establishes the theoretical foundations of a general methodology for multiple hypothesis testing and discusses its software implementation in R and SAS. These are applied to a range of problems in biomedical and genomic research, including identification of differentially expressed and co-expressed genes in high-throughput gene expression experiments; tests of association between gene expression measures and biological annotation metadata; sequence analysis; and genetic mapping of complex traits using single nucleotide polymorphisms. The procedures are based on a test statistics joint null distribution and provide Type I error control in testing problems involving general data generating distributions, null hypotheses, and test statistics.
商品描述(中文翻譯)
本書建立了多重假設檢定的一般方法論的理論基礎,並討論了其在 R 和 SAS 中的軟體實作。這些方法應用於生物醫學和基因組研究中的一系列問題,包括在高通量基因表達實驗中識別差異表達和共同表達的基因;基因表達測量與生物註解元數據之間的關聯性檢定;序列分析;以及使用單核苷酸多態性進行複雜性狀的遺傳圖譜繪製。這些程序基於檢定統計量的聯合虛無分佈,並在涉及一般數據生成分佈、虛無假設和檢定統計量的檢定問題中提供第一類錯誤控制。