Unraveling the Exposome: A Practical View
暫譯: 解開外顯組:實用觀點
- 出版商: Springer
- 出版日期: 2018-10-20
- 售價: $6,600
- 貴賓價: 9.5 折 $6,270
- 語言: 英文
- 頁數: 447
- 裝訂: Hardcover
- ISBN: 3319893203
- ISBN-13: 9783319893204
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商品描述
This volume presents a comprehensive overview of the science and application of the Exposome through seventeen chapters from leaders in the field. At just over ten years since the term was coined by Christopher Wild in 2005, this is the first, field-defining volume to offer a holistic picture of the important and growing field of Exposomics.
The term “Exposome” describes the sum of all exposures (not only chemical) that an individual can receive over a lifetime from both exogenous sources (environmental contaminants, food, lifestyle, drugs, air, etc.) and endogenous sources (metabolism, oxidative stress, lipid peroxidation, chemicals synthesized by the microbiome, etc.). The first section of this book contains chapters that discuss how the Exposome is defined and how the concept fits into the fields of public health and epidemiology. The second section provides an overview of techniques and methods to measure the human Exposome. The third section contains methods and applications for measuring the Exposome through external exposures. Section four provides an overview on statistical and computational techniques- including big data analysis - for characterizing the Exposome. Section five presents a global collection of case studies
商品描述(中文翻譯)
本卷提供了對 Exposome 科學及應用的全面概述,包含來自該領域領導者的十七章內容。自從 2005 年 Christopher Wild 首次提出這個術語以來,已經過去十多年,這是第一本定義該領域的著作,提供了 Exposomics 這一重要且不斷增長的領域的整體圖景。
“Exposome” 這個術語描述了個體在一生中所接觸到的所有暴露(不僅僅是化學物質)的總和,這些暴露來自外源性來源(環境污染物、食物、生活方式、藥物、空氣等)和內源性來源(代謝、氧化壓力、脂質過氧化、微生物組合成的化學物質等)。本書的第一部分包含討論 Exposome 定義及其如何融入公共衛生和流行病學領域的章節。第二部分提供了測量人類 Exposome 的技術和方法概述。第三部分包含通過外部暴露測量 Exposome 的方法和應用。第四部分提供了統計和計算技術的概述,包括大數據分析,用於特徵化 Exposome。第五部分展示了一系列全球案例研究。