Computational Biology: A Practical Introduction to Bio Data Juggling with Worked Examples
暫譯: 計算生物學:生物數據處理的實用入門與範例解析

Wünschiers, Röbbe

  • 出版商: Springer
  • 出版日期: 2025-02-19
  • 售價: $4,100
  • 貴賓價: 9.5$3,895
  • 語言: 英文
  • 頁數: 513
  • 裝訂: Hardcover - also called cloth, retail trade, or trade
  • ISBN: 3031703138
  • ISBN-13: 9783031703133
  • 海外代購書籍(需單獨結帳)

商品描述

This extensively expanded third edition offers a practical introduction to Bio Data Science. With a hands-on approach to learning, this book offers ample opportunities to practice:

- Installing and utilizing Linux as a virtual machine or remotely
- Processing bio data with the programming language AWK
- Managing data with the relational database system MariaDB
- Analyzing and visualizing data with R
- Implementing good bioinformatics practices with Jupyter Notebook and GitHub

This book targets both students and professionals in the life sciences. While it is aimed at beginners, it also provides valuable tips and tricks for experienced researchers dealing with large datasets.

Worked examples illustrate how to utilize various bioinformatics tools such as BLAST, Clustal, PLINK, IGV, SAMtools, BCFtools, Mason2, Minimap, NCBI Datasets, Velvet, Jmol, and more for:

- Identifying bacterial proteins potentially associated with pathogenicity
- Querying molecular structures for redox-regulated enzymes
- Mapping and assembling real or simulated sequence reads
- Identifying and mapping molecular structure mutations in viruses
- Conducting genome-wide association studies

All software tools and datasets mentioned are freely available, and all code is accessible as Jupyter Notebooks on GitHub. Drawing from the author's experiences and knowledge gained from both academia and industry, this book provides a practical and comprehensive approach to bioinformatics.

商品描述(中文翻譯)

這本 extensively expanded 第三版提供了生物數據科學的實用入門。透過實作學習的方法,本書提供了豐富的練習機會:

- 安裝並使用 Linux 作為虛擬機或遠端使用
- 使用程式語言 AWK 處理生物數據
- 使用關聯式資料庫系統 MariaDB 管理數據
- 使用 R 進行數據分析和可視化
- 使用 Jupyter Notebook 和 GitHub 實施良好的生物資訊學實踐

本書的目標讀者為生命科學的學生和專業人士。雖然本書針對初學者,但也提供了對於處理大型數據集的經驗研究者的寶貴提示和技巧。

實作範例展示了如何利用各種生物資訊學工具,如 BLAST、Clustal、PLINK、IGV、SAMtools、BCFtools、Mason2、Minimap、NCBI Datasets、Velvet、Jmol 等,進行以下操作:

- 識別可能與致病性相關的細菌蛋白質
- 查詢氧化還原調控酶的分子結構
- 繪製和組裝真實或模擬的序列讀取
- 識別和繪製病毒中的分子結構突變
- 進行全基因組關聯研究

所有提到的軟體工具和數據集均可免費獲得,所有代碼可作為 Jupyter Notebooks 在 GitHub 上訪問。這本書根據作者在學術界和產業界獲得的經驗和知識,提供了一種實用且全面的生物資訊學方法。

作者簡介

Röbbe Wünschiers is a professor of biochemistry and molecular biology at the University of Applied Sciences Mittweida. For over two decades, he has been working with molecular, biological, genetic engineering, and computational methods in both academic and industrial environments. He is the author of textbooks and numerous didactic and popular science articles. This new edition of Computational Biology includes insightful tips and tricks from his extensive teaching experience at various universities and his experience as a bioinformatician at BASF Plant Science.

作者簡介(中文翻譯)

Röbbe Wünschiers 是美特維達應用科技大學的生物化學與分子生物學教授。二十多年來,他一直在學術和工業環境中從事分子、生物、基因工程和計算方法的研究。他是教科書和多篇教學及科普文章的作者。這本《計算生物學》的新版本包含了他在多所大學的豐富教學經驗以及他在BASF植物科學擔任生物資訊學家的經驗所提供的深入見解和技巧。