Dispersity, Structure and Phase Changes of Proteins and Bio Agglomerates in Biotechnological Processes
Kwade, Arno, Kampen, Ingo
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商品描述
This book serves as a comprehensive summary of the priority program SPP 1934, which focused on understanding the dispersity, structure, and phase changes of proteins and bio-agglomerates in biotechnological processes. Through contributions from various research groups, the program explored how sensitive proteins and bio-agglomerates are affected by the process environment during fermentation, downstream processing, and formulation. It investigated these effects across three size scales: microscale, encompassing single proteins, clusters, crystals, and virus-like particles; mesoscale, focusing on cells and cell clusters; and macroscale, examining overall process dynamics. The main objective was to enhance biotechnological process chains by elucidating the mechanical, thermal, and chemical stresses that impact protein and bio-agglomerate structures. By gaining insights into these stressors, the program aimed to enable precise control measures to mitigate denaturation and unfavorable growth of proteins and cells. This compilation seeks to contribute to the optimization of biotechnological processes, facilitating advancements in various industries.
商品描述(中文翻譯)
本書是對SPP 1934優先計劃的全面總結，該計劃的重點是理解生物技術過程中蛋白質和生物凝聚體的分散性、結構和相變化。通過來自不同研究團隊的貢獻，該計劃探討了敏感蛋白質和生物凝聚體在發酵、下游處理和配方過程中受到的工藝環境的影響。它在三個尺度上研究了這些影響：微觀尺度，包括單個蛋白質、聚集體、晶體和類病毒粒子；中觀尺度，關注細胞和細胞聚集體；宏觀尺度，研究整個過程的動態。主要目標是通過闡明影響蛋白質和生物凝聚體結構的機械、熱和化學應力，提高生物技術過程鏈的效能。通過獲得對這些應力因素的深入了解，該計劃旨在實現精確的控制措施，以減輕蛋白質和細胞的變性和不利生長。本書的編輯旨在為生物技術過程的優化做出貢獻，促進各個行業的進步。
作者簡介
Prof. Dr.-Ing. Arno Kwade (Technische Universität Braunschweig) worked 9 years as a process engineer in leading industrial positions after finishing his doctorate in 1996. In 2005, he was appointed as Professor and Director of the Institute for Particle Technology (iPAT) at Technische Universität Braunschweig. Today at TU Braunschweig he is Vice President for Transfer and Innovation and spokesperson of the interdisciplinary research centres Battery LabFactory Braunschweig (BLB) and Center of Pharmaceutical Engineering (PVZ). Moreover, he is vice chairman of BMBF advisory board Battery Research Germany, coordinator of BMBF competency cluster for battery cell production (ProZell) and member of Fraunhofer Institute for Thin Films (IST). His research focus lies on developing deep knowledge, process-structure-property relationships and numerical simulations for processes in which particles are mechanically stressed and formulated, from milling and mechanochemical synthesis over mixing and powder handling and characterization to production of drug and bio products and battery electrodes. He received awards like the Lower Saxony Science Award in 2021 and Hans Rumpf medal in 2022. Together with colleagues he published nearly 500 papers which are cited more than 12,000 times.
Dr.-Ing. Ingo Kampen (Technische Universität Braunschweig) studied biotechnology before completing his doctoral thesis in the field of protein purification in 2005. He then became head of the pharmaceutical and bioparticle technology department at the Institute for Particle Technology (iPAT), where he still works today. His main field of work is the measurement of micromechanical properties of biological particles such as cross-linked protein crystals or individual cells in order to better understand their denaturation and damage during use in various processes. He was managing director of the DFG priority programme 1934 'Dispersity, Structure and Phase Changes of Proteins and Bio-Agglomerates in Biotechnological Processes'. He is also heavily involved in teaching and played a key role in the development of the Master's degree programme in Pharmaceutical Process Engineering at Technische Universität Braunschweig.
作者簡介(中文翻譯)
Prof. Dr.-Ing. Arno Kwade（布倫瑞克工業大學）在1996年取得博士學位後，曾在領先的工業職位擔任過9年的工藝工程師。2005年，他被任命為布倫瑞克工業大學粒子技術研究所（iPAT）的教授和所長。如今，他是布倫瑞克工業大學的轉移與創新副校長，也是跨學科研究中心Battery LabFactory Braunschweig（BLB）和Center of Pharmaceutical Engineering（PVZ）的發言人。此外，他還是德國聯邦教育和研究部（BMBF）電池研究諮詢委員會的副主席，BMBF電池電池生產能力集群（ProZell）的協調人，以及Fraunhofer薄膜研究所（IST）的成員。他的研究重點是開發深入的知識、過程-結構-性能關係和粒子在機械應力和配方中的數值模擬，從研磨和機械化學合成到混合和粉末處理和表徵，以及藥物和生物產品和電池電極的生產。他獲得了2021年下薩克森科學獎和2022年漢斯·朗普夫獎章等獎項。與同事們合作，他發表了近500篇論文，被引用超過12,000次。
Dr.-Ing. Ingo Kampen（布倫瑞克工業大學）在2005年完成蛋白質純化領域的博士論文之前，曾就讀生物技術專業。之後，他成為粒子技術研究所（iPAT）製藥和生物顆粒技術部門的負責人，至今仍在該部門工作。他的主要研究領域是測量生物顆粒（如交聯蛋白晶體或個別細胞）的微機械性質，以更好地了解它們在各種過程中的變性和損壞。他曾擔任德國研究基金會（DFG）重點計劃1934“蛋白質和生物聚集物在生物技術過程中的分散性、結構和相變化”（Dispersity, Structure and Phase Changes of Proteins and Bio-Agglomerates in Biotechnological Processes）的總經理。他還積極參與教學工作，並在布倫瑞克工業大學的藥物過程工程碩士學位課程的開發中發揮了關鍵作用。
