Introduction to BioMEMS (Hardcover)

<內容簡介>

How Do We Make Small Things?

• Why Bother Making Things Small?
• From Art to Chips
• Photolithography
• Micromachining
• Micromolding
• Soft Lithography
• Hydrogel Devices
• Nanofabrication Techniques
• Fabrication Based on Self-Assembly: A "Bottom-Up" Approach

Micropatterning of Substrates and Cells

• Interaction between Surfaces and Biomolecules
• Surface Engineering
• Micropatterns of SAMs
• Micropatterns of Proteins
• Micropatterns of Cells on Nonbiomolecular Templates
• Micropatterns of Cells on Biomolecular Templates

Microfluidics

• Why Go Small?
• Microscale Behavior of Fluids
• Fluids in Electrical Fields
• Fluids in Acoustic Fields
• Fabrication of Microfluidic Channels
• Operation of Microfluidic Channels: Practical Concerns
• Droplet Microfluidics
• Active Flow Control
• Micromixers
• Combinatorial Mixers

Molecular Biology on a Chip

• The Importance of Miniaturizing Molecular Biology
• The Importance of Point-of-Care Diagnostics: Where is Cost Really, Really, Really Important?
• Sample Preparation: A Bloody Example
• The Problem with Microfluidic Sample Separation
• Microfluidic Immunoassays
• Chips for Genomics and Proteomics
• Electrospray Mass Spectrometry
• Biochemical Analysis Using Force Sensors

Cell-Based Chips for Biotechnology

• Microfluidic Flow Cytometers
• Cell Sorting
• Cell Trapping
• Microfluidic Cell Culture Laboratories
• Gene Expression Cellular Microarrays ("Cellomics")
• Micro-Bioreactors
• Cells on Microelectrodes
• Patch Clamp Chips
• Cryopreservation
• Assisted Reproductive Technologies
• Whole Animal Testing

BioMEMS for Cell Biology

• An Enabling Technology: The Hurdles
• Cell-Substrate Signaling
• Cell-Cell Communication
• Cell Migration
• BioMEMS for Cellular Neurobiology
• Developmental Biology on a Chip
• Yeast Biology
• Plant Cell Biology
• Microfluidics for Studying Cellular Dynamics

Tissue Microengineering

• Microscaffolding
• Micropatterned Cocultures
• Stem Cell Engineering
• Morphogenesis

Implantable Microdevices

• Dental Implants
• Implantable Microelectrodes
• Delivery of Soluble Signals into the Body
• Microtools for Surgery
• Insect Research

Appendix

Index