Receptors in the Evolution and Development of the Brain: Matter Into Mind
暫譯: 大腦的進化與發展中的受體:物質轉化為心智
Fine, Richard E.
- 出版商: Academic Press
- 出版日期: 2019-06-18
- 售價: $3,730
- 貴賓價: 9.5 折 $3,544
- 語言: 英文
- 頁數: 282
- 裝訂: Quality Paper - also called trade paper
- ISBN: 0128110120
- ISBN-13: 9780128110126
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商品描述
Receptors in the Evolution and Development of the Brain: Matter into Mind presents the key role of receptors and their cognate ligands in wiring the mammalian brain from an evolutionary developmental biology perspective. It examines receptor function in the evolution and development of the nervous system in the large vertebrate brain, and discusses rapid eye movement sleep and apoptosis as mechanisms to destroy miswired neurons. Possible links between trophic deficits and connectional diseases including Alzheimer's, Parkinson's, and ALS are also discussed. This book is extremely useful to those with an interest in the molecular and cellular neurosciences, including those in cognitive and clinical branches of this subject, and anyone interested in how the incredibly complex human brain can build itself.
- Provides an understanding of the key role receptors play in brain development and the selection process necessary to construct a large brain
- Traces the evolution of receptors from the most primitive organisms to humans
- Emphasizes the roles that REM sleep and apoptosis play in this selection via trophic factors and receptors
- Describes the role that trophic factor-receptor interactions play throughout life and how trophic deficits can lead to connectional diseases, including Alzheimer's, Parkinson's and ALS
- Provides a potential mechanism whereby neuronal stem cells can cure these diseases
商品描述(中文翻譯)
《大腦的進化與發展中的受體:物質轉化為心智》從進化發展生物學的角度,展示了受體及其相應配體在哺乳動物大腦連接中的關鍵角色。它探討了受體在大型脊椎動物大腦神經系統進化與發展中的功能,並討論了快速眼動睡眠(REM sleep)和細胞凋亡(apoptosis)作為摧毀錯誤連接神經元的機制。書中還討論了營養缺失與連接性疾病之間的可能聯繫,包括阿茲海默症(Alzheimer's)、帕金森病(Parkinson's)和肌萎縮側索硬化症(ALS)。這本書對於對分子和細胞神經科學感興趣的人士,包括認知和臨床領域的研究者,以及任何對人類大腦如何構建自身的驚人複雜性感興趣的人,都非常有用。
- 提供對受體在大腦發展中所扮演的關鍵角色及構建大型大腦所需選擇過程的理解
- 追溯受體從最原始生物到人類的進化
- 強調快速眼動睡眠和細胞凋亡在這一選擇過程中通過營養因子和受體所扮演的角色
- 描述營養因子-受體互動在整個生命過程中的作用,以及營養缺失如何導致連接性疾病,包括阿茲海默症、帕金森病和ALS
- 提供一種潛在機制,說明神經幹細胞如何能治癒這些疾病