Eskape Pathogens: Detection, Mechanisms and Treatment Strategies

本書探討了「ESKAPE」病原體，包括醫學上重要的Enterococcus faecium、Staphylococcus aureus、Klebsiella pneumoniae、Acinetobacter baumannii、Pseudomonas aeruginosa和Enterobacter spp.，以及抗生素抗藥性所帶來的挑戰。書中涵蓋了ESKAPE病原體的抗藥性概況和檢測方法，以及對這些病原體抗藥性機制的理解。書中討論了標準的微生物學技術，包括染色、形態和培養特性、生化特性和血清分型，以及核酸放大和分子診斷技術用於檢測ESKAPE病原體。此外，本書還探討了ESKAPE病原體毒力因子的生化、分子和計算技術的確定方法。書中還研究了這些病原體的毒力因子和生物膜成分的合成、結構、功能和抑制劑。本書探討了各種對抗ESKAPE病原體的策略，包括抗生素輔助劑及其協同作用、植物化合物作為潛在的抗菌劑、光動力療法、抗菌肽和抗菌抗體、納米材料和納米複合材料的抗菌活性，以及噬菌體療法。最後，本書討論了「in silico」和計算方法用於抑制ESKAPE病原體。這本綜合性的書對於對ESKAPE病原體的診斷、預防和治療感興趣的研究人員、學生和醫療專業人員具有重要意義。

Dr. Siddhardha Busi, Ph.D. is Assistant Professor in the Department of Microbiology, Pondicherry University, Puducherry, India. He has more than 12 years of research experience in the field of Microbiology, Microbial Pathogenesis, Antimicrobial drug discovery and Nanobiotechnology. He is working on antimicrobial compounds and antimicrobial drug discovery especially to understand their mechanism of action. He worked at Biology Division, CSIR-IICT, Hyderabad, India for his doctoral studies (Ph.D). He completed two research projects on antiquorum sensing and antibiofilm activities of natural products, funded by Government of India. He is extensively working in the field of Microbial Pathogenesis, Host-Pathogen interactions, Antibiotic resistance, nanotechnology, especially applications of nanotechnology in drug discovery, drug delivery, sustained release and photodynamic therapy. Currently his group is working on Bacterial quorum sensing, Biofilms, Antimicrobial photodynamic therapy and nanobiotechnology. He is editorial board member of several reputed journals. He has also published more than 80 research articles in the peer-reviewed international journals and authored or co-authored numerous book chapters. He edited four books. He is a member of many national and international scientific societies. He has more than 12 years of teaching and research experience at the University level.

Ram Prasad, Ph.D. is Associate Professor, Department of Botany, Mahatma Gandhi Central University, Motihari, Bihar, India. His research interest includes applied & environmental microbiology, plant-microbe-interactions, sustainable agriculture, chemistry of biology, and nanobiotechnology. Dr. Prasad has more than two hundred fifty publications to his credit, including research papers, review articles & book chapters and seven patents issued or pending, and edited or authored several books. Dr. Prasad has twelve years of teaching experience and has been awarded the Young Scientist Award & Prof. J.S. Datta Munshi Gold Medal by the International Society for Ecological Communications; Fellow of Biotechnology Research society of India; Fellow of the Society for Applied Biotechnology; the American Cancer Society UICC International Fellowship for Beginning Investigators, USA; Outstanding Scientist Award in the field of Microbiology by Venus International Foundation; BRICPL Science Investigator Award and Research Excellence Award etc. He has been serving as editorial board members: Nanotechnology Reviews; Green Processing and Synthesis; BMC Microbiology; BMC Biotechnology; Current Microbiology; Archives of Microbiology; Annals of Microbiology; BioMed Research International, IET Nanobiotechnology; Journal of Nanomaterials; Nanotechnology for Environmental Engineering; Journal of Renewable Material; Journal of Agriculture and Food Research; SN Applied Sciences; Agriculture etc., etc. including Series editor of Nanotechnology in the Life Sciences, Springer Nature, USA. Previously, Dr. Prasad served as Assistant Professor at Amity University Uttar Pradesh, India; Visiting Assistant Professor, Whiting School of Engineering, Department of Mechanical Engineering at Johns Hopkins University, Baltimore, United States and Research Associate Professor at School of Environmental Science and Engineering, Sun Yat-sen University, Guangzhou, China.

Dr. Siddhardha Busi博士是印度普杜切里大學微生物學系的助理教授。他在微生物學、微生物病原學、抗微生物藥物發現和納米生物技術領域擁有超過12年的研究經驗。他正在研究抗微生物化合物和抗微生物藥物發現，特別是為了了解它們的作用機制。他在印度海得拉巴的CSIR-IICT生物學部門進行了博士研究（博士學位）。他完成了兩個由印度政府資助的關於天然產物的抗生物膜活性和抗生物感應的研究項目。他在微生物病原學、宿主-病原體相互作用、抗生素抗藥性、納米技術尤其是納米技術在藥物發現、藥物傳遞、持續釋放和光動力療法中的應用方面進行了廣泛的研究。目前，他的團隊正在研究細菌的群體感應、生物膜、抗微生物光動力療法和納米生物技術。他是多個知名期刊的編輯委員會成員。他在同行評審的國際期刊上發表了80多篇研究論文，並撰寫或合著了許多專書章節。他編輯了四本書。他是許多國內外科學學會的成員。他在大學層面擁有超過12年的教學和研究經驗。

Ram Prasad博士是印度比哈爾邦莫提哈里馬哈特瑪·甘地中央大學植物學系的副教授。他的研究興趣包括應用與環境微生物學、植物-微生物相互作用、可持續農業、生物學化學和納米生物技術。Prasad博士已發表了超過250篇論文，包括研究論文、綜述文章和專書章節，並獲得七項已獲得或待批准的專利，並編輯或撰寫了多本書籍。Prasad博士擁有十二年的教學經驗，並獲得了國際生態傳播學會頒發的青年科學家獎和J.S. Datta Munshi教授金牌獎；印度生物技術研究學會會士；應用生物技術學會會士；美國癌症協會UICC國際初級研究員獎學金；由Venus國際基金會頒發的微生物學領域傑出科學家獎；BRICPL科學調查員獎和研究卓越獎等。他擔任多個期刊的編輯委員會成員，包括Nanotechnology Reviews、Green Processing and Synthesis、BMC Microbiology、BMC Biotechnology、Current Microbiology、Archives of Microbiology、Annals of Microbiology、BioMed Research International、IET Nanobiotechnology、Journal of Nanomaterials、Nanotechnology for Environmental Engineering、Journal of Renewable Material、Journal of Agriculture and Food Research、SN Applied Sciences、Agriculture等等，並擔任Springer Nature出版的Nanotechnology in the Life Sciences系列的系列編輯。此前，Prasad博士曾在印度北方邦的Amity大學擔任助理教授；在美國巴爾的摩的約翰霍普金斯大學工程學院機械工程系擔任訪問助理教授；在中國廣州的中山大學環境科學與工程學院擔任研究副教授。