This handbook reviews the clinical applications of stem cell-based therapy. The book covers the clinical applications of stem cells in cardiovascular diseases, neurological and ocular diseases, pediatrics, and the role of cancer stem cell-derived exosomal microRNA payload in lung cancer. The chapter reviews emerging stem cell therapy and tissue engineering approaches in neurodegenerative diseases. The book further examines the applications of stem cells in various fields of dentistry, and for the regeneration of oral and non-oral tissues. The chapters also explore the application of 3D bioprinting in conjunction with bone marrow mesenchymal stem cells for the treatment of bone defects and state-of-the-art technology for bone and cartilage regeneration using mesenchymal stem cells. The book presents stem cell-based therapy against renal, pancreatic, and kidney diseases and examines the advantages of a novel hepatic stem for cirrhotic liver repair and regeneration. Lastly, the book provides methodological and procedural advancements in stem cell-based therapy, including the applications of single-cell sequencing in stem cell research. This handbook is a major one-stop reference for researchers working in regenerative medicine, cellular pharmacology, stem cell research in general, and those involved in specific areas of adult stem cells as well as embryonic and induced pluripotent stem cells.
這本手冊回顧了幹細胞治療的臨床應用。該書涵蓋了幹細胞在心血管疾病、神經和眼科疾病、兒科以及肺癌中的應用。該章節回顧了在神經退行性疾病中新興的幹細胞治療和組織工程方法。該書進一步探討了幹細胞在牙科各個領域的應用，以及用於口腔和非口腔組織再生的方法。這些章節還探討了3D生物打印與骨髓間質幹細胞結合治療骨缺陷以及使用間質幹細胞進行骨和軟骨再生的最新技術。該書介紹了幹細胞治療對腎臟、胰臟和腎臟疾病的應用，並檢視了一種新型肝臟幹細胞在肝硬化修復和再生中的優勢。最後，該書提供了幹細胞治療中的方法和程序進展，包括單細胞测序在幹細胞研究中的應用。這本手冊是一本重要的綜合參考資料，適用於從事再生醫學、細胞藥理學、幹細胞研究以及成體幹細胞、胚胎幹細胞和誘導多能幹細胞等特定領域研究的研究人員。
Dr. Khawaja Husnain Haider is a Professor of Cellular and Molecular Pharmacology (Stem Cell and Gene Therapy) and Chairman of the Basic Sciences Department (Medical Program) at Sulaiman AlRajhi University. Before his current assignment, he served in several prestigious institutions in various parts of the world. He has also served as Principal Investigator (PI) and Co-PI on multiple National Institute of Health (NIH) funded stem cell research projects. He has been on the editorial boards and invited reviewer panels for several respected international journals. His research focuses on using, either alone or in combination, DNA, miRNAs, and stem cells as "drugs," a topic that has gained popularity in regenerative medicine. He has extensively published in cellular and sub-cellular preconditioning of stem cells besides using their conditioned media for cell-free therapy. He has published nearly 325 book chapters, abstracts, and research papers in various books and leading research journals, including Circulation, Circulation Research, Cardiovascular Research, JCMM, the Journal of Biological Chemistry, Cell Cycle, Basic Research in Cardiology, and Antioxidant Redox Signaling. He has also given numerous presentations and edited ten books covering various facets of stem cells and their applications from drug to drug development.
Dr. Khawaja Husnain Haider是Sulaiman AlRajhi大學的細胞和分子藥理學（幹細胞和基因治療）教授，也是基礎科學部門（醫學計劃）的主任。在現任之前，他曾在世界各地的幾所知名機構任職。他還擔任過多個國家衛生研究院（NIH）資助的幹細胞研究項目的主要研究員（PI）和共同研究員（Co-PI）。他曾擔任多個受尊敬的國際期刊的編輯委員會和邀請評審小組成員。他的研究重點是使用DNA、miRNA和幹細胞作為“藥物”，這是再生醫學中越來越受歡迎的話題。除了使用幹細胞的條件培養基進行無細胞治療外，他還廣泛發表了關於幹細胞的細胞和亞細胞預處理的研究。他在各種書籍和領先的研究期刊上發表了近325篇專書章節、摘要和研究論文，包括《循環》、《循環研究》、《心血管研究》、《JCMM》、《生物化學雜誌》、《細胞週期》、《基礎心臟研究》和《抗氧化紅氧化信號》。他還做過許多演講，並編輯了十本關於幹細胞及其應用從藥物到藥物開發的書籍。
