Lectures on Statistical Physics and Protein Folding (Paperback)
暫譯: 統計物理與蛋白質摺疊講義 (平裝本)
Kerson Huang
- 出版商: World Scientific Pub
- 出版日期: 2005-05-31
- 售價: $790
- 貴賓價: 9.8 折 $774
- 語言: 英文
- 頁數: 158
- 裝訂: Paperback
- ISBN: 9812561501
- ISBN-13: 9789812561503
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相關分類:
物理學 Physics
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商品描述
Description:
This book introduces an approach to protein folding from the point of view of kinetic theory. There is an abundance of data on protein folding, but few proposals are available on the mechanism driving the process. Here, presented for the first time, are suggestions on possible research directions, as developed by the author in collaboration with C C Lin.
The first half of this invaluable book contains a concise but relatively complete review of relevant topics in statistical mechanics and kinetic theory. It includes standard topics such as thermodynamics, the MaxwellBoltzmann distribution, and ensemble theory. Special discussions include the dynamics of phase transitions, and Brownian motion as an illustration of stochastic processes.
The second half develops topics in molecular biology and protein structure, with a view to discovering mechanisms underlying protein folding. Attention is focused on the energy flow through the protein in its folded state. A mathematical model, based on the Brownian motion of coupled harmonic oscillators, is worked out in the appendix.
Table of Contents:
- Entropy
- MaxwellBoltzmann Distribution
- Free Energy
- Chemical Potential
- Phase Transitions
- Kinetics of Phase Transitions
- The Order Parameter
- Correlation Function
- Stochastic Processes
- Langevin Equation
- The Life Process
- Self-Assembly
- Kinetics of Protein Folding
- Power Laws in Protein Folding
- Self-Avoiding Walk and Turbulence
- Convergent Evolution in Protein Folding
商品描述(中文翻譯)
**描述:**
本書從動力學理論的角度介紹了蛋白質摺疊的方式。雖然有大量關於蛋白質摺疊的數據,但對於驅動該過程的機制卻提出的建議不多。在此,首次提出了可能的研究方向,這些方向是作者與林志成(C C Lin)合作開發的。
本書的前半部分包含了對統計力學和動力學理論相關主題的簡明但相對完整的回顧。它包括熱力學、麥克斯韋-玻爾茲曼分佈和系統理論等標準主題。特別討論包括相變化的動力學,以及布朗運動作為隨機過程的例證。
後半部分發展了分子生物學和蛋白質結構的主題,旨在發現蛋白質摺疊背後的機制。重點放在蛋白質在其摺疊狀態下的能量流動。附錄中詳細介紹了一個基於耦合諧振子布朗運動的數學模型。
**目錄:**
- 熵
- 麥克斯韋-玻爾茲曼分佈
- 自由能
- 化學勢
- 相變化
- 相變化的動力學
- 有序參數
- 相關函數
- 隨機過程
- 蘭傑文方程
- 生命過程
- 自組裝
- 蛋白質摺疊的動力學
- 蛋白質摺疊中的冪律
- 自避行走與湍流
- 蛋白質摺疊中的收斂演化