Cutting-Edge Organic Synthesis and Chemical Biology of Bioactive Molecules: The Shape of Organic Synthesis to Come
暫譯: 前沿有機合成與生物活性分子的化學生物學：未來有機合成的形狀

Kobayashi, Yuichi

Cutting-Edge Organic Synthesis and Chemical Biology of Bioactive Molecules: The Shape of Organic Synthesis to Come
  • 出版商: Springer
  • 出版日期: 2019-06-14
  • 售價: $4,890
  • 貴賓價: 9.5 折 $4,646
  • 語言: 英文
  • 頁數: 355
  • 裝訂: Hardcover - also called cloth, retail trade, or trade
  • ISBN: 9811362432
  • ISBN-13: 9789811362439

    • 海外代購書籍(需單獨結帳)

相關主題

商品描述

This book describes cutting-edge organic syntheses of biologically active compounds, isolation of pharmaceutically promising compounds from microorganisms, drug design, and progress on chemical biology. Synthetic strategy and tactics are summarized for super-carbon chain compounds, antitumor polycycles, aryl C-glycoside, antimycins, duocarmycins, cannabinoids, and other compounds. Special chapters are devoted to synthesis and biochemistry of fatty acid metabolites, which play a central role in the initiation and resolution of inflammation. The book provides a quick survey of trending topics in organic synthesis and chemical tools for biological investigation, and furnishes ideas for future research in organic synthesis. In addition, the contents can easily be understood by young chemists, graduate students, and those who are looking for new research based on organic chemistry.


商品描述(中文翻譯)

本書描述了生物活性化合物的前沿有機合成、從微生物中分離具有藥物潛力的化合物、藥物設計以及化學生物學的進展。對於超碳鏈化合物、抗腫瘤多環化合物、芳基C-糖苷、抗黴菌素、雙卡黴素、大麻素及其他化合物的合成策略和戰術進行了總結。特別章節專門探討脂肪酸代謝物的合成和生物化學，這些代謝物在炎症的啟動和解決中扮演著核心角色。本書提供了有機合成和生物研究化學工具的趨勢主題的快速概覽，並為未來的有機合成研究提供了靈感。此外，內容易於年輕化學家、研究生以及尋求基於有機化學的新研究的人士理解。

作者簡介

Yuichi KOBAYASHI received Ph.D. from the Tokyo Institute of Technology in 1981. His supervisors were Professors Jiro Tsuji and Fumie Sato at the Tokyo Institute of Technology and Gibert Stork at Columbia University. He is a full Professor at Tokyo Institute of Technology. His research interests include organic synthesis using transition metal catalysts and developments of chiral C-C bond formation. Targets include fatty acid metabolites known as resolvins and leukotrienes, isoprostanes, epi-jasmonates, tetrahydrocannabinoids, cinchona alkaloids, phoslactomycins, etc. The picolinoxy leaving group in allylic substitution has created tertially and quaternary carbons. These achievements have been published in internationally renowned journals such as Angew. Chem. Int. Ed., Org. Lett., Nature, Chem. Eur. J. He has 35 years of teaching experience at the Tokyo Institute of Technology.

作者簡介(中文翻譯)

小林裕一（Yuichi KOBAYASHI）於1981年獲得東京科技大學（Tokyo Institute of Technology）的博士學位。他的指導教授為東京科技大學的辻次郎（Jiro Tsuji）和佐藤文江（Fumie Sato），以及哥倫比亞大學（Columbia University）的吉伯特·斯托克（Gibert Stork）。他目前是東京科技大學的正教授。他的研究興趣包括使用過渡金屬催化劑的有機合成以及手性C-C鍵形成的發展。研究目標包括已知的脂肪酸代謝物如解決素（resolvins）和白三烯（leukotrienes）、異前列腺素（isoprostanes）、表茉莉酸（epi-jasmonates）、四氫大麻素（tetrahydrocannabinoids）、金雞納鹼（cinchona alkaloids）、磷乳霉素（phoslactomycins）等。在烯丙基取代反應中，吡啶氧基（picolinoxy）離去基團創造了三級和四級碳。這些成就已發表在國際知名期刊上，如《Angew. Chem. Int. Ed.》、《Org. Lett.》、《Nature》和《Chem. Eur. J.》。他在東京科技大學擁有35年的教學經驗。

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