Genome Mapping and Genomics in Human and Non-Human Primates (Genome Mapping and Genomics in Animals)
暫譯: 人類與非人類靈長類的基因組繪製與基因組學(動物基因組繪製與基因組學)

  • 出版商: Springer
  • 出版日期: 2015-04-22
  • 售價: $6,740
  • 貴賓價: 9.5$6,403
  • 語言: 英文
  • 頁數: 305
  • 裝訂: Hardcover
  • ISBN: 3662463059
  • ISBN-13: 9783662463055
  • 海外代購書籍(需單獨結帳)

相關主題

商品描述

This book provides an introduction to the latest gene mapping techniques and their applications in biomedical research and evolutionary biology. It especially highlights the advances made in large-scale genomic sequencing. Results of studies that illustrate how the new approaches have improved our understanding of the genetic basis of complex phenotypes including multifactorial diseases (e.g., cardiovascular disease, type 2 diabetes, and obesity), anatomic characteristics (e.g., the craniofacial complex), and neurological and behavioral phenotypes (e.g., human brain structure and nonhuman primate behavior) are presented.

Topics covered include linkage and association methods, gene expression, copy number variation, next-generation sequencing, comparative genomics, population structure, and a discussion of the Human Genome Project. Further included are discussions of the use of statistical genetic and genetic epidemiologic techniques to decipher the genetic architecture of normal and disease-related complex phenotypes using data from both humans and non-human primates.

商品描述(中文翻譯)

本書介紹了最新的基因圖譜技術及其在生物醫學研究和進化生物學中的應用。特別強調了在大規模基因組測序方面所取得的進展。研究結果顯示,這些新方法如何改善我們對複雜表型的遺傳基礎的理解,包括多因素疾病(例如心血管疾病、2型糖尿病和肥胖症)、解剖特徵(例如顱面複合體)以及神經和行為表型(例如人類大腦結構和非人類靈長類動物行為)。

涵蓋的主題包括連鎖和關聯方法、基因表達、拷貝數變異、下一代測序、比較基因組學、族群結構,以及對人類基因組計畫的討論。此外,還討論了使用統計遺傳學和遺傳流行病學技術,利用來自人類和非人類靈長類動物的數據來解碼正常和與疾病相關的複雜表型的遺傳結構。