Oxidative Stress in Cardiovascular-Metabolic Diseases
Eid, Ali Hussein, Kobeissy, Firas, El-Yazbi, Ahmed
- 出版商: Springer
- 出版日期: 2024-08-08
- 售價: $6,380
- 貴賓價: 9.5 折 $6,061
- 語言: 英文
- 頁數: 325
- 裝訂: Hardcover - also called cloth, retail trade, or trade
- ISBN: 3031621301
- ISBN-13: 9783031621307
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商品描述
The book dissects the role of oxidative stress in the pathogenesis of the leading causes of global morbidity and mortality, i.e.cardiovascular and metabolic diseases. The chapters discuss topics related to the role reactive oxygen species (ROS) play in hypertension, atherosclerosis, diabetes, obesity and related pathologies. The authors also shed light on gender differences in the onset and pathologies of some of these diseases. Moreover, how ROS and aging interplay to precipitate cardiovasculo-metabolic disease is discussed and highlighted. Preventive measures that can abrogate ROS-induced cardiovasclo-metabolic disease are discussed and clarified in the hope of reducing such a debilitating battery of diseases. A section dedicated to antioxidants as potential therapy is also included. Furthermore, given the complexity of the mechanisms implicated in ROS-modulated responses, it remains challenging to assert a conclusive argument and pre-determined regimen for incorporating antioxidants into conventional therapies. Nonetheless, results from some clinical trials appear promising, warranting the addition of a chapter dedicated to such human trials.
In all of the chapters, the molecular, cellular, genetic, and pharmacological mechanisms implicated are covered from an applied science perspective.
This is an ideal book for basic researchers in the biomedical field, graduate students in biological and biomedical fields, medical students, instructors in medical and graduate schools, and professionals working for pharmaceutical companies.
商品描述(中文翻譯)
這本書剖析了氧化壓力在全球主要致病率和死亡率的原因，即心血管和代謝性疾病的發病機制。各章節討論了活性氧物種（ROS）在高血壓、動脈粥樣硬化、糖尿病、肥胖和相關病理中的作用。作者還闡明了某些疾病發病和病理的性別差異。此外，討論並強調了ROS和衰老如何相互作用以促成心血管代謝性疾病的發生。書中還討論了可以防止ROS誘發心血管代謝性疾病的預防措施，並希望減少這些令人傷殘的疾病。書中還包括了一節專門介紹抗氧化劑作為潛在治療方法。此外，由於ROS調節反應的機制複雜，確定將抗氧化劑納入常規治療的結論和預定方案仍然具有挑戰性。儘管如此，一些臨床試驗的結果顯示出有希望的效果，因此有必要增加一章專門介紹這些人體試驗。
在所有章節中，從應用科學的角度涵蓋了分子、細胞、基因和藥理學機制。
這本書非常適合生物醫學領域的基礎研究人員、生物學和生物醫學領域的研究生、醫學生、醫學和研究生院的教師，以及在製藥公司工作的專業人士。
作者簡介
Dr. Ali Hussein Eid, PhD, is an Associate Professor of Pharmacology at Qatar University.
Firas H. Kobaissy received a Ph.D. in molecular Neuroscience from the University of Florida (Gainesville) under the direction of Dr. Kevin K. Wang and Dr. Mark S. Gold. Most of his research focused on brain injury due to mechanical insult or due to drug abuse neurotoxicity using rat model. Dr. Kobaissy utilizes the state of the art proteomics tools to investigate cell death mechanisms involved in different brain insults.
Ahmed F. El-Yazbi graduated from the Faculty of Pharmacy, Alexandria University, Egypt in June 2001 with top honors. He moved on to get his PhD degree from the Faculty of Medicine at the University of Alberta in Edmonton, Canada, which was awarded in 2007. After the conclusion of his PhD, Dr. El-Yazbi was awarded two fellowships from the Canadian Institutes for Health Research and Alberta Innovates-Health Solutions, during which he conducted a research program studying the regulation of cerebral blood flow at the Faculty of Medicine in the University of Calgary, Canada. He is also a licensed Clinical Pharmacist and a Board-Certified Pharmacotherapy Specialist with extensive experience in highly specialized pharmaceutical services. Dr. El-Yazbi has a very solid university-level teaching and research track record evident in over 15 years of experience teaching to pharmacy and medical students in Canadian, Egyptian, and Lebanese universities. He also has over nine years of experience as a clinical pharmacist. He has over 30 original research articles published in international peer-reviewed journals and serves as an independent reviewer for a number of scientific/professional journals and bodies. Dr. El-Yazbi's contributions are recognized by invitations to present, speak, and chair scientific sessions in multiple national, regional, and international venues. Ahmed's current research and teaching interests at University level focus on investigating the mechanisms of vascular dysfunction in early stages of metabolic disease together with the identification of possible targets for therapeutic intervention with these detrimental pathways, in addition to related Pharmacy Practice and Therapeutic issues.
作者簡介(中文翻譯)
Dr. Ali Hussein Eid, PhD，是卡塔爾大學藥理學副教授。
Firas H. Kobaissy在佛羅里達大學（Gainesville）獲得分子神經科學博士學位，指導教授為Dr. Kevin K. Wang和Dr. Mark S. Gold。他的大部分研究集中在使用大鼠模型研究由於機械損傷或藥物濫用神經毒性引起的腦損傷。Kobaissy博士利用先進的蛋白質組學工具研究不同腦損傷中涉及的細胞死亡機制。
Ahmed F. El-Yazbi於2001年以優異成績從埃及亞歷山大大學藥學院畢業。他隨後在加拿大愛德蒙頓的亞伯達大學醫學院獲得博士學位，該學位於2007年獲得。在博士學位結束後，El-Yazbi博士獲得了加拿大健康研究院和亞伯達創新健康解決方案兩個獎學金，期間他在加拿大卡爾加里大學醫學院進行了一項研究計劃，研究了腦血流的調節。他還是一位持牌臨床藥師和經過認證的藥物治療專家，具有豐富的高度專業化藥學服務經驗。El-Yazbi博士在加拿大、埃及和黎巴嫩的大學教授藥學和醫學學生方面擁有15年以上的經驗，並且擔任多個國際同行評審期刊和機構的獨立評審人。El-Yazbi博士的貢獻獲得了在多個國家、地區和國際場合發表、演講和主持科學會議的邀請。Ahmed目前在大學層面上的研究和教學興趣集中在早期代謝疾病血管功能障礙機制的研究，以及在這些有害途徑中可能的治療干預目標的確定，此外還包括相關的藥學實踐和治療問題。
