Rodent Quality Control: Genes and Bugs: Monitoring Health and Genetics of Laboratory Animals
Benavides, Fernando J., Hansen, Axel Kornerup
- 出版商: Springer
- 出版日期: 2024-08-13
- 售價: $7,030
- 貴賓價: 9.5 折 $6,679
- 語言: 英文
- 頁數: 279
- 裝訂: Hardcover - also called cloth, retail trade, or trade
- ISBN: 303159102X
- ISBN-13: 9783031591020
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商品描述
This book shows how and why quality assurance programmes should be implemented in laboratory rodent facilities to monitor animal health and genetic status. It covers common practice to assure the desired level of microbiological and genetic surveillance of both genetically standardized and genetically altered laboratory mice and rats. In particular, the book introduces readers to the standardized genetic nomenclature and provides step-by-step protocols for genetic monitoring of the animals. International standards of health monitoring programs are discussed and statistical aspects thereof are explored. Furthermore, the book reviews common infectious diseases in laboratory rodents and guides the reader in monitoring the animals' health status through application of current diagnostic methods.
This book adresses researchers, technicians and zookeepers working in laboratory rodent facilities.
商品描述(中文翻譯)
本書介紹了為了監測實驗室鼠類設施中的動物健康和基因狀態，應如何實施品質保證計劃。它涵蓋了確保達到所需的微生物和基因監測水平的常見做法，包括對基因標準化和基因改變的實驗室小鼠和大鼠進行監測。特別是，本書介紹了標準化的基因命名法，並提供了動物基因監測的逐步操作指南。討論了國際健康監測計劃的標準，並探討了統計方面的相關問題。此外，本書還回顧了實驗室鼠類常見的傳染病，並指導讀者通過應用當前的診斷方法來監測動物的健康狀況。
本書針對在實驗室鼠類設施工作的研究人員、技術人員和動物園飼養員。
作者簡介
Dr. Fernando Benavides is Professor and Director of the Laboratory Animal Genetic Services at MD Anderson Cancer Center, Houston, Texas. Dr. Benavides received a DVM and a PhD in Genetics from the University of Buenos Aires, Argentina. His PhD training on Mouse Genetics was done at Institut Pasteur, Paris, France. Dr. Benavides is a diplomate of the American College of Laboratory Animal Medicine (ACLAM) since 2003 and he serves as IACUC veterinarian for the MD Anderson Cancer Center since 2006. Dr. Benavides has a strong background in positional cloning of spontaneous mutations and has described several new mouse models. He has published 70 peer-reviewed papers in scientific journals, several books, chapters and reviews on Mouse Genetics and Genetic Quality Controls in mice and rats.
Dr. Axel Kornerup Hansen graduated in 1985 as DVM from the Royal Veterinary and Agricultural University in Copenhagen, Denmark. After two years in a small animal hospital, he became head of laboratories at Møllegaard Breeding Center, today part of Taconic Ltd. In 1993 he became associate director at the Department of Experimental Medicine at the Faculty of Health & Medical Sciences at the University of Copenhagen. In 1996 he was awarded the degree of Dr. Vet. Sci. based upon his thesis on the impact of bacteria in laboratory rats. From 1997 he has been professor in laboratory animal science and welfare at the Royal Veterinary and Agricultural University, which in 2007 became a part of University of Copenhagen. In 2000 Dr. Hansen was made charter diplomat and was together with six others founding the European College of Laboratory Animal Medicine. His research area has primarily been on how infections and the microbiota have an impact on laboratory animal models for human diseases and how this works in conjunction with the diet, but he has also published work on laboratory animal welfare. Dr. Hansen has published 223 peer-reviewed papers in scientific journals, 20 proceedings papers, 17 papers in non-peer journals, and two full textbooks, i.e. 'The Laboratory Swine' and 'Handbook of Laboratory Animal Bacteriology' from CRC Press. He is chairing the board of the Danish National Centre for the 3Rs.
作者簡介(中文翻譯)
Dr. Fernando Benavides是德州休斯頓的MD Anderson癌症中心的教授和實驗動物遺傳服務實驗室的主任。Benavides博士在阿根廷布宜諾斯艾利斯大學獲得獸醫學博士學位和遺傳學博士學位。他在法國巴斯德研究所進行了鼠類遺傳學的博士後培訓。Benavides博士自2003年起是美國實驗動物醫學學院（ACLAM）的專科醫生，自2006年起擔任MD Anderson癌症中心的IACUC獸醫。Benavides博士在自發性突變的位置克隆方面具有豐富的背景，並描述了幾個新的鼠模型。他在科學期刊上發表了70篇同行評審的論文，以及關於鼠類遺傳學和鼠和大鼠的遺傳質量控制的幾本書籍、章節和評論。
Dr. Axel Kornerup Hansen於1985年畢業於丹麥哥本哈根的皇家獸醫和農業大學，獲得獸醫學博士學位。在一家小動物醫院工作兩年後，他成為Møllegaard繁殖中心實驗室的負責人，該中心現在是Taconic Ltd的一部分。1993年，他成為哥本哈根大學健康與醫學科學學院實驗醫學系的副主任。1996年，他以他關於實驗鼠中細菌影響的論文獲得獸醫科學博士學位。從1997年開始，他擔任皇家獸醫和農業大學的實驗動物科學和福利教授，該大學於2007年成為哥本哈根大學的一部分。2000年，Hansen博士成為創始成員之一，與其他六位共同創立了歐洲實驗動物醫學學院。他的研究主要集中在感染和微生物群落對人類疾病實驗動物模型的影響以及與飲食的相互作用，但他也發表了有關實驗動物福利的研究成果。Hansen博士在科學期刊上發表了223篇同行評審的論文，20篇會議論文，17篇非同行評審期刊論文，以及兩本完整的教科書，即CRC Press出版的《實驗豬》和《實驗動物細菌學手冊》。他目前擔任丹麥3R國家中心的董事會主席。
