Obesity, Diabetes and Inflammation: Molecular Mechanisms and Clinical Management

肥胖是一種全球性的流行病，影響著五億人。據估計，如果當前趨勢持續到2050年，全球60%的男性和50%的女性將會肥胖。由於超重和肥胖引起的白色脂肪組織的肥大和增生導致了慢性炎症狀態，這會造成胰島素敏感性受損並發展成糖尿病。目前，全球受糖尿病影響的人數已超過4億（在低收入和中等收入國家增長更快）。在2019年，糖尿病是第九大死亡原因，估計直接死亡人數達150萬。

本書提供了炎症、肥胖和糖尿病之間關係的全面概述。它專注於肥胖的發病機制和生物學機制、脂肪組織與免疫系統之間的相互作用、遺傳和環境因素的角色、心血管併發症的進展，以及肥胖和炎症與1型和2型糖尿病以及妊娠糖尿病的關聯。本書還包括了使用生活方式改變和藥物干預來預防和管理這些疾病的實用建議。

由該領域的專家撰寫的《肥胖、糖尿病與炎症：分子機制與臨床管理》探討了炎症在肥胖和糖尿病中的作用、對血管和非血管病理的影響、氧化壓力、遺傳學和表觀遺傳學。這本書旨在成為研究人員、臨床醫生和各級醫學生的寶貴資源。

Dimiter Avtanski, Ph.D. is currently a Director of the Endocrine Research Laboratory at Friedman Diabetes Institute of Lenox Hill Hospital in New York City, Associate Professor of Medicine at Donald and Barbara Zucker School of Medicine at Hofstra/Northwell in Hempstead, New York, and Assistant Professor at the Institute of Bioelectronic Medicine at Feinstein Institutes for Medical Research in Manhasset, New York. He received his M.Sc. degree in Biology and Chemistry from Sofia University in Bulgaria and his Ph.D. from the Bulgarian Academy of Sciences in collaboration with Beth Israel Medical Center at Albert Einstein College of Medicine in New York City. Dr. Avtanski specialized at Leipzig University, Germany, and completed seven years of post-doctoral fellowships at The Johns Hopkins University School of Medicine in Baltimore, Maryland. His main research focuses on the connection between obesity, diabetes, and breast cancer progression.

Dr. Leonid Poretskyis Chief, Division of Endocrinology; Associate Chairman for Research; Director of the Gerald J. Friedman Diabetes Institute; and the Founding Director, The Gerald J. Friedman Transgender Program for Health and Wellness--all in the Department of Medicine, Lenox Hill Hospital, New York City. He is also Professor of Medicine at Hofstra Northwell School of Medicine and Feinstein Institutes for Medical Research. Dr. Poretsky was born in St. Petersburg, Russia, where he graduated from First (Pavlov) Medical Institute summa cum laude in 1977. Upon immigrating to the United States in 1979 and completing medical residency, he graduated from the endocrinology fellowship at Boston's Beth Israel Hospital (now Beth Israel/Deaconess Medical Center) and Harvard Medical School. He has authored over 150 publications and is the editor of a 1,000 page textbook entitled "Principles of Diabetes Mellitus", currently in its 3rd edition. He is also the editor of "Contemporary Endocrinology" and co-editor of "Transgender Medicine: A Multidisciplinary Approach," all published by Springer Publishing, Inc. His research interests include the relationship between energy metabolism and reproduction, endocrinological aspects of HIV-infection, and clinical studies in diabetes. His research projects have been supported over the years by philanthropy, industry and government grants, including the grants from the National Institutes of Health (NIH) and the New York State Department of Health. He has served on the NIH grant review committees and on the editorial boards of the Journal of Clinical Endocrinology and Metabolism and other journals.

Dimiter Avtanski 博士目前是紐約市 Lenox Hill 醫院 Friedman 糖尿病研究所的內分泌研究實驗室主任，Hofstra/Northwell Donald 和 Barbara Zucker 醫學院的內科副教授，以及 Feinstein 醫學研究所生物電子醫學研究所的助理教授。他在保加利亞索非亞大學獲得生物學和化學的碩士學位，並在與紐約市的 Beth Israel 醫療中心合作下，從保加利亞科學院獲得博士學位。Avtanski 博士曾在德國萊比錫大學專攻，並在馬里蘭州巴爾的摩的約翰霍普金斯大學醫學院完成七年的博士後研究。他的主要研究集中於肥胖、糖尿病與乳腺癌進展之間的關聯。

Leonid Poretsky 博士是內分泌學部門的主任、研究副主席、Gerald J. Friedman 糖尿病研究所的主任，以及 Lenox Hill 醫院內科的創始主任，負責 Gerald J. Friedman 跨性別健康與福祉計畫。他同時也是 Hofstra Northwell 醫學院和 Feinstein 醫學研究所的內科教授。Poretsky 博士出生於俄羅斯聖彼得堡，1977 年以優異成績畢業於第一醫學學院（Pavlov）。1979 年移民至美國後，他完成了醫學住院醫師訓練，並在波士頓的 Beth Israel 醫院（現為 Beth Israel/Deaconess 醫療中心）和哈佛醫學院完成內分泌學的研究員訓練。他已發表超過 150 篇論文，並編輯了一本名為《糖尿病原則》的 1,000 頁教科書，目前已進入第三版。他也是《當代內分泌學》的編輯，以及《跨性別醫學：多學科方法》的共同編輯，這些書籍均由 Springer Publishing, Inc. 出版。他的研究興趣包括能量代謝與生殖之間的關係、HIV 感染的內分泌學方面，以及糖尿病的臨床研究。他的研究項目多年來獲得慈善機構、產業和政府補助的支持，包括來自國家衛生研究院（NIH）和紐約州衛生部的補助。他曾擔任 NIH 補助審查委員會成員，以及《臨床內分泌學與代謝雜誌》和其他期刊的編輯委員會成員。