Molecular Mechanisms of Neurotransmitter Release

Wang, Zhao-Wen

  • 出版商: Springer
  • 出版日期: 2024-08-25
  • 售價: $7,630
  • 貴賓價: 9.5$7,249
  • 語言: 英文
  • 頁數: 401
  • 裝訂: Quality Paper - also called trade paper
  • ISBN: 3031342313
  • ISBN-13: 9783031342318
  • 海外代購書籍(需單獨結帳)

相關主題

商品描述

Neurons communicate with each other by releasing neurotransmitters. This book provides comprehensive coverage of the molecular mechanisms involved in neurotransmitter release. The topics covered in the book range from the architecture and cytomatrix proteins of presynaptic sites, to the modes of synaptic vesicle exocytosis (full-collapse and kiss-and-run), and from the key molecules mediating synaptic vesicle fusion (SNAREs) to those that closely interact with them (UNC-13/Munc13, UNC-18/Munc18, tomosyn, and complexins). The book also delves into the calcium sensors of synaptic vesicle fusion (synaptotagmins and Doc2s), the sources of calcium that trigger synaptic exocytosis (voltage-gated calcium channels and ryanodine receptors), and the regulation of neurotransmitter release by potassium channels, cell adhesion molecules, lipids, aryl hydrocarbon receptor-interacting protein (AIP), presenilins, and calstabins. To aid in understanding and illustrate key concepts, the book includes sufficient background information and a wealth of illustrations and diagrams. The new edition includes major updates to previous chapters, as well as several new chapters that reflect the recent advances in the field. Comprehensive and cutting-edge, Molecular Mechanisms of Neurotransmitter Release, 2nd edition, is a valuable learning resource for neuroscience students and a solid reference for neuroscientists.

商品描述(中文翻譯)

神經元透過釋放神經傳遞物質相互交流。本書全面涵蓋了涉及神經傳遞物質釋放的分子機制。書中討論的主題包括突觸前部位的結構和細胞基質蛋白,突觸囊泡的外排模式(完全崩潰和吻合-跑),以及介導突觸囊泡融合的關鍵分子(SNAREs)和與其密切互動的分子(UNC-13/Munc13、UNC-18/Munc18、tomosyn 和 complexins)。本書還深入探討了突觸囊泡融合的鈣感應器(synaptotagmins 和 Doc2s)、觸發突觸外排的鈣來源(電壓門控鈣通道和 ryanodine 受體),以及鉀通道、細胞黏附分子、脂質、芳香烴受體相互作用蛋白(AIP)、前賽尼林和 calstabins 對神經傳遞物質釋放的調控。為了幫助理解並說明關鍵概念,本書提供了足夠的背景資訊以及大量的插圖和圖表。新版本對先前章節進行了重大更新,並新增了幾個反映該領域近期進展的章節。《神經傳遞物質釋放的分子機制》(第二版)是神經科學學生的寶貴學習資源,也是神經科學家堅實的參考資料。

作者簡介

​Zhao-Wen Wang, PhD, is Professor of Neuroscience in the Faculty of Neuroscience, Cell Biology, and Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, Connecticut. His major research interests are on the functions and regulation of the BK channel and gap junctions, and molecular mechanisms of neurotransmitter release.


作者簡介(中文翻譯)

趙文王博士是康乃爾大學健康中心神經科學、細胞生物學及遺傳學與發展生物學系的教授。他的主要研究興趣包括BK通道和間隙連接的功能與調控,以及神經傳遞物質釋放的分子機制。