Biomarkers for Huntington's Disease: Improving Clinical Outcomes (亨廷頓舞蹈症的生物標記：改善臨床結果)

Thomas, Elizabeth A., Parkin, Georgia M.

Biomarkers for Huntington's Disease: Improving Clinical Outcomes
  • 出版商: Springer
  • 出版日期: 2024-10-13
  • 售價: $7,820
  • 貴賓價: 9.5 折 $7,429
  • 語言: 英文
  • 頁數: 475
  • 裝訂: Quality Paper - also called trade paper
  • ISBN: 3031328175
  • ISBN-13: 9783031328176

    • 海外代購書籍(需單獨結帳)

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商品描述

Huntington's disease (HD) is a fatal, inherited, neurodegenerative disorder, characterized by chorea, motor instabilities, psychiatric manifestations and cognitive decline. Early genetic testing provides an opportunity for clinical interventions aimed at delaying onset and/or slowing progression of disease; however, current treatments for HD are limited, with only two FDA-approved drugs available to manage chorea. Encouragingly, however, several disease-modifying treatment approaches are in the therapeutic pipeline, with more than 200 clinical studies, and many more preclinical studies, in the works. Robust and reliable biomarkers are needed to predict disease onset, monitor disease progression and assess treatment responses. More specifically, biomarkers to stratify patients for clinical trials and biomarkers to track drug efficacy will certainly lead to improved clinical trial design and success. This book represents the first book focused solely on biomarkers for HD and represents adistinct resource that will be informative, not only for clinicians and those involved in clinical trial design, but also for a wide range of neurodegenerative disease researchers. This edited volume is written by top leaders in the field, and takes a cross-disciplinary approach to cover a broad spectrum of biomarker types, in order to provide the latest advances in the development of biochemical, molecular, imaging and digital biomarkers that have been investigated for HD. With the ultimate goal of treating patients, the development of disease-associated biomarkers has never been more important.

作者簡介

Elizabeth A. Thomas, Ph.D.

Elizabeth A. Thomas received her Bachelor's degree in biochemistry from the University of California (UC), Berkeley in 1989, and then studied at the UC Irvine, School of Medicine, receiving her Ph.D. in pharmacology in 1994. International appointments include time as an Adjunct Research Officer at the Mental Health Research Institute of Victoria in Melbourne, Australia, followed by an Honorary Senior Research Fellow at The Florey Institute of Neuroscience and Mental, Health, also in Melbourne, Australia. She is currently the laboratory director of the Institute for Interdisciplinary Salivary Bioscience Research at UC Irvine, and also holds positions of Research Professor in the Department of Neurobiology and Human Behavior at UC Irvine, and Adjunct Associate Professor in the Department of Neuroscience at the S^100 peer-reviewed publications to date, and her work has appeared in journals such as Nature Neuroscience, Proceedings of the National Academy of Sciences, Cell Stem Cell, Human Molecular Genetics, Biological Psychiatry and Molecular Psychiatry.

Georgia M. Parkin, Ph.D.

Georgia M. Parkin received her Bachelor's degree in biochemistry from the University of Melbourne, Australia in 2011, her Master's degree in neuroscience from the University of Zurich, Switzerland in 2014, and her Ph.D. in neuroscience from the Florey Institute of Neuroscience and Mental Health, and the University of Melbourne, Australia in 2019. Her work has spanned the fields of traumatic brain injury, psychiatric illness with a focus on schizophrenia and bipolar disorder, and Huntington's disease. Dr. Parkin is academically trained in laboratory-based research, with her past studies focusing on cell culture and mouse models, as well as human subjects and clinical patients, and involving biospecimens such as post-mortem brain tissue, blood, saliva and cerebrospinal fluid. Concurrent to, and following, completion of her Ph.D., Dr.Parkin has also specialized in clinical biomarker research, through appointments at the Murdoch Children's Research Institute and Royal Melbourne Hospital, Australia, and the Institute for Interdisciplinary Salivary Bioscience Research at University of California, Irvine. She currently works in the Department of Neurosciences at the University of California, San Diego, and is part of the Huntington's Disease Society of America Center of Excellence at this site. Her published work has been featured in journals including Nature Neuroscience, Neuroscience and Biobehavioral Reviews, Bipolar Disorders, International Journal of Molecular Sciences, among others; her research has also been shared by multiple news sites.

作者簡介(中文翻譯)

伊莉莎白·A·托馬斯（Elizabeth A. Thomas），博士
伊莉莎白·A·托馬斯於1989年在加州大學伯克利分校獲得生物化學學士學位，隨後在加州大學爾灣分校醫學院攻讀，於1994年獲得藥理學博士學位。她的國際任職經歷包括在澳大利亞墨爾本的維多利亞精神健康研究所擔任兼任研究官，之後在同樣位於墨爾本的弗洛里神經科學與心理健康研究所擔任榮譽高級研究員。她目前是加州大學爾灣分校跨學科唾液生物科學研究所的實驗室主任，同時在加州大學爾灣分校的神經生物學與人類行為系擔任研究教授，以及在神經科學系擔任兼任副教授。至今，她已發表超過100篇經過同行評審的出版物，並且她的研究成果出現在《自然神經科學》、《美國國家科學院院刊》、《細胞幹細胞》、《人類分子遺傳學》、《生物精神病學》和《分子精神病學》等期刊上。

喬治亞·M·帕金（Georgia M. Parkin），博士
喬治亞·M·帕金於2011年在澳大利亞墨爾本大學獲得生物化學學士學位，2014年在瑞士蘇黎世大學獲得神經科學碩士學位，並於2019年在弗洛里神經科學與心理健康研究所及澳大利亞墨爾本大學獲得神經科學博士學位。她的研究涵蓋創傷性腦損傷、精神疾病，特別是精神分裂症和雙相情感障礙，以及亨廷頓舞蹈症。帕金博士在實驗室研究方面受過學術訓練，過去的研究集中在細胞培養和小鼠模型，以及人類受試者和臨床病人，並涉及生物樣本如死後腦組織、血液、唾液和腦脊髓液。在完成博士學位的同時及之後，帕金博士還專注於臨床生物標記研究，曾在澳大利亞墨爾本的默多克兒童研究所和皇家墨爾本醫院，以及加州大學爾灣分校的跨學科唾液生物科學研究所任職。她目前在加州大學聖地牙哥分校的神經科學系工作，並且是該地點亨廷頓舞蹈症美國協會卓越中心的一部分。她的研究成果已發表在《自然神經科學》、《神經科學與生物行為評論》、《雙相情感障礙》、《國際分子科學期刊》等期刊上，並且她的研究也被多個新聞網站報導。

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