The Biology of Senescence: A Translational Approach
暫譯: 衰老生物學：一種轉譯方法

Swynghedauw, Bernard

The Biology of Senescence: A Translational Approach
  • 出版商: Springer
  • 出版日期: 2019-06-18
  • 售價: $3,420
  • 貴賓價: 9.5 折 $3,249
  • 語言: 英文
  • 頁數: 121
  • 裝訂: Hardcover - also called cloth, retail trade, or trade
  • ISBN: 3030151107
  • ISBN-13: 9783030151102

    • 海外代購書籍(需單獨結帳)

商品描述

This book describes the fundamental process of senescence, and reviews a new concept developed by a number of research groups that is based on cellular senescence and its secretome. This concept provides a basic explanation of the main physiological and pathological features of senescence, and delineates possibilities for "treating" it.

Following an introduction to the emerging medical landscape, the increasing incidence of a new epidemiological group (age-related "chronic non-transmissible diseases"), and the multiple origins of aging, the book explores and characterizes the senescent cell, which is linked to benign and pathological age-related manifestations. In turn, the closing chapters discuss how to "treat" or "prevent" the aging process, underscoring the central role of physical exercise and caloric reduction as compared to new senolytic approaches. Appendices are also provided, and address circadian rhythms, telomere shortening, diabetic cardiomyopathy, and senescence in plants and bacteria.

Given its scope, the book will primarily be of interest to geriatricians, but will also appeal to a wider range of clinicians.

商品描述(中文翻譯)

這本書描述了衰老的基本過程，並回顧了由多個研究團隊發展出的一個新概念，該概念基於細胞衰老及其分泌物。這個概念提供了衰老主要生理和病理特徵的基本解釋，並勾勒出“治療”衰老的可能性。

在介紹新興醫療環境、與年齡相關的“慢性非傳染性疾病”這一新流行病學群體的日益增加，以及衰老的多重起源之後，這本書探討並特徵化了與良性和病理性年齡相關表現有關的衰老細胞。隨後，最後幾章討論了如何“治療”或“預防”衰老過程，強調了與新型清除衰老細胞方法相比，身體運動和熱量減少的核心作用。書中還提供了附錄，涉及生理節律、端粒縮短、糖尿病性心肌病以及植物和細菌中的衰老。

鑑於其範疇，這本書主要會引起老年醫學專家的興趣，但也會吸引更廣泛的臨床醫生。

作者簡介

Bernard Swynghedauw is a former Research Director of the French National Institute of Health and Medical Research (INSERM), Paris, France. In 1974 he became a laboratory director at INSERM and, from 1992 to 1999, served as director of the special course for postgraduate cardiologists and pneumonologists "Biologie et Physiologie de la Circulation et de la Respiration." He currently teaches a course on Cardiovascular Geriatrics at Bicêtre Hospital in Paris. He has won a number of prestigious awards (CEDUS in 1996; Peter Debye in 1994, University of Maastricht, NL; Drieux-Cholet in 1996, Académie de Médecine Paris), and is a corresponding member of the French Académie de Médecine, of the Academia Europeae, former member of the Executive Committee of the European Society of Cardiology (ESC), and Past-President of the Federation of European Physiological Societies (FEPS). He has authored several books and numerous articles in prominent international journals.

作者簡介(中文翻譯)

伯納德·斯溫赫道（Bernard Swynghedauw）是法國國家健康與醫學研究院（INSERM）前研究主任，位於法國巴黎。1974年，他成為INSERM的實驗室主任，並於1992年至1999年期間擔任研究生心臟病學家和肺病學家的特別課程「循環與呼吸的生物學與生理學」（Biologie et Physiologie de la Circulation et de la Respiration）主任。他目前在巴黎的比塞特醫院（Bicêtre Hospital）教授心血管老年醫學課程。他獲得了多項著名獎項（1996年CEDUS；1994年馬斯特里赫特大學的彼得·德拜獎（Peter Debye）；1996年巴黎醫學院的德里厄-肖萊獎（Drieux-Cholet）），並且是法國醫學院的通訊會員、歐洲學院的成員、歐洲心臟病學會（ESC）執行委員會的前成員，以及歐洲生理學會聯合會（FEPS）的前會長。他著有多本書籍及在多個國際知名期刊上發表了大量文章。

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