Bioinformatics and Phylogenetics: Seminal Contributions of Bernard Moret
暫譯: 生物資訊學與系統發生學：伯納德·莫雷特的開創性貢獻

Warnow, Tandy

Bioinformatics and Phylogenetics: Seminal Contributions of Bernard Moret
  • 出版商: Springer
  • 出版日期: 2019-04-17
  • 售價: $4,510
  • 貴賓價: 9.5 折 $4,285
  • 語言: 英文
  • 頁數: 410
  • 裝訂: Hardcover - also called cloth, retail trade, or trade
  • ISBN: 3030108368
  • ISBN-13: 9783030108366
  • 相關分類: 生物資訊 Bioinformatics

    • 海外代購書籍(需單獨結帳)

商品描述

This volume presents a compelling collection of state-of-the-art work in algorithmic computational biology, honoring the legacy of Professor Bernard M.E. Moret in this field. Reflecting the wide-ranging influences of Prof. Moret's research, the coverage encompasses such areas as phylogenetic tree and network estimation, genome rearrangements, cancer phylogeny, species trees, divide-and-conquer strategies, and integer linear programming. Each self-contained chapter provides an introduction to a cutting-edge problem of particular computational and mathematical interest.

Topics and features: addresses the challenges in developing accurate and efficient software for the NP-hard maximum likelihood phylogeny estimation problem; describes the inference of species trees, covering strategies to scale phylogeny estimation methods to large datasets, and the construction of taxonomic supertrees; discusses the inference of ultrametric distances from additive distance matrices, and the inference of ancestral genomes under genome rearrangement events; reviews different techniques for inferring evolutionary histories in cancer, from the use of chromosomal rearrangements to tumor phylogenetics approaches; examines problems in phylogenetic networks, including questions relating to discrete mathematics, and issues of statistical estimation; highlights how evolution can provide a framework within which to understand comparative and functional genomics; provides an introduction to Integer Linear Programming and its use in computational biology, including its use for solving the Traveling Salesman Problem.

Offering an invaluable source of insights for computer scientists, applied mathematicians, and statisticians, this illuminating volume will also prove useful for graduate courses on computational biology and bioinformatics.

商品描述(中文翻譯)

本卷呈現了一系列尖端的演算法計算生物學研究，致敬於伯納德·M.E.·莫雷特教授在該領域的貢獻。反映莫雷特教授研究的廣泛影響，內容涵蓋了系統發生樹和網路估計、基因組重排、癌症系統發生學、物種樹、分而治之策略以及整數線性規劃等領域。每一章都是獨立的，提供了對特定計算和數學興趣的尖端問題的介紹。

主題和特點：針對開發準確且高效的軟體以解決 NP-hard 的最大似然系統發生估計問題所面臨的挑戰；描述物種樹的推斷，涵蓋將系統發生估計方法擴展到大型數據集的策略，以及分類超樹的構建；討論從加法距離矩陣推斷超度量距離，以及在基因組重排事件下推斷祖先基因組；回顧在癌症中推斷演化歷史的不同技術，從使用染色體重排到腫瘤系統發生學的方法；檢視系統發生網路中的問題，包括與離散數學相關的問題和統計估計的議題；強調演化如何提供一個框架，以理解比較基因組學和功能基因組學；介紹整數線性規劃及其在計算生物學中的應用，包括解決旅行推銷員問題的用途。

這本啟發性的著作為計算機科學家、應用數學家和統計學家提供了寶貴的見解，對於計算生物學和生物資訊學的研究生課程也將非常有用。

作者簡介

Dr. Tandy Warnow is the Founder Professor of Computer Science at the University of Illinois at Urbana-Champaign, where she is also an affiliate in the departments of Mathematics, Statistics, Bioengineering, Electrical and Computer Engineering, Animal Biology, Entomology, and Plant Biology. Tandy received her PhD in Mathematics in 1991 at UC Berkeley under the direction of Gene Lawler, and did postdoctoral training with Simon Tavaré and Michael Waterman at USC. Her research combines computer science, statistics, and discrete mathematics, focusing on developing improved models and algorithms for reconstructing complex and large-scale evolutionary histories in biology and historical linguistics. She has published more than 160 papers and one textbook, graduated 11 PhD students, and has 5 current PhD students. Her awards include the NSF Young Investigator Award (1994), the David and Lucile Packard Foundation Award (1996), a Radcliffe Institute Fellowship (2006), and the John Simon Guggenheim Foundation Fellowship (2011). She was elected a Fellow of the Association for Computing Machinery (ACM) in 2015 and of the International Society for Computational Biology (ISCB) in 2017. Warnow succeeded Bernard Moret as the director of the NSF-funded CIPRES (Cyber-Infrastructure for Phylogenetic Research) project, whose goal was "To provide the computational infrastructure needed to reconstruct phylogenies for millions of taxa".

作者簡介(中文翻譯)

坦迪·沃諾（Dr. Tandy Warnow）是伊利諾伊大學香檳分校計算機科學的創始教授，同時她也是數學、統計學、生物工程、電氣與計算機工程、動物生物學、昆蟲學和植物生物學等多個系所的聯聘教授。坦迪於1991年在加州大學伯克利分校獲得數學博士學位，指導教授為基恩·洛勒（Gene Lawler），並在南加州大學（USC）與西蒙·塔瓦雷（Simon Tavaré）和邁克爾·沃特曼（Michael Waterman）進行博士後訓練。她的研究結合了計算機科學、統計學和離散數學，專注於開發改進的模型和算法，以重建生物學和歷史語言學中的複雜和大規模進化歷史。她已發表超過160篇論文和一本教科書，培養了11名博士生，並且目前有5名在讀博士生。她的獎項包括國家科學基金會（NSF）青年研究者獎（1994年）、大衛與露西爾·帕卡德基金會獎（1996年）、拉德克利夫研究所獎學金（2006年）以及約翰·西蒙·古根海姆基金會獎學金（2011年）。她於2015年被選為計算機協會（ACM）院士，並於2017年被選為國際計算生物學學會（ISCB）院士。沃諾接替伯納德·莫雷特（Bernard Moret）成為國家科學基金會資助的CIPRES（系統發育研究的網絡基礎設施）項目的主任，其目標是「提供重建數百萬物種系統發育所需的計算基礎設施」。

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