New Organocatalytic Strategies for the Selective Synthesis of Centrally and Axially Chiral Molecules
暫譯: 新型有機催化策略用於選擇性合成中心和軸向手性分子

Di Iorio, Nicola

New Organocatalytic Strategies for the Selective Synthesis of Centrally and Axially Chiral Molecules
  • 出版商: Springer
  • 出版日期: 2019-01-26
  • 售價: $4,950
  • 貴賓價: 9.5 折 $4,703
  • 語言: 英文
  • 頁數: 180
  • 裝訂: Quality Paper - also called trade paper
  • ISBN: 3030091031
  • ISBN-13: 9783030091033

    • 海外代購書籍(需單獨結帳)

相關主題

商品描述

This thesis discusses the use of asymmetric organic catalysis for the direct enantioselective synthesis of complex chiral molecules, and by addressing the many aspects of both vinylogy and atropisomerism, it appeals to researchers and scholars interested in both areas.

Organocatalysis is a relatively modern and "hot" topic in the chemical community; it is constantly expanding and its use has been extended to interesting areas like vinylogous reactivity and atropisomerism. Vinylogous systems are very important for their synthetic applications but also pose a number of challenges, the most notable of which are their reduced reactivity and the reduced stereocontrol at these positions. On the other hand, atropisomeric systems are even more important because of the huge potential they have as drugs, ligands and catalysts. Chemists have only recently "recognized" the importance of these two areas and are focusing their efforts on studying them and the challenges they pose.

This thesis offers an extensive introduction on the general aspects of chirality and organocatalysis and an equally extensive experimental section that allow nonexperts to understand the discussion section and reproduce the experiments.

商品描述(中文翻譯)

這篇論文討論了不對稱有機催化在複雜手性分子的直接對映選擇合成中的應用，並通過探討 vinylogy 和 atropisomerism 的多個方面，吸引了對這兩個領域感興趣的研究人員和學者。

有機催化在化學界是一個相對現代且「熱門」的主題；它不斷擴展，其應用已延伸至 vinylogous 反應性和 atropisomerism 等有趣的領域。Vinylogous 系統在合成應用中非常重要，但也帶來了一些挑戰，其中最顯著的是它們的反應性降低以及在這些位置的立體控制減弱。另一方面，atropisomeric 系統因其作為藥物、配體和催化劑的巨大潛力而更為重要。化學家們最近才「認識到」這兩個領域的重要性，並將精力集中在研究它們及其所帶來的挑戰上。

這篇論文提供了關於手性和有機催化的一般性廣泛介紹，以及同樣廣泛的實驗部分，使非專家能夠理解討論部分並重現實驗。

作者簡介

Nicola Di Iorio was born in 1989. During his studies at the University of Bologna, Italy he spent a year abroad at UCLA (University of California, Los Angeles, USA) before graduating (cum laude) in Industrial Chemistry in October 2013. Immediately afterwards, he started his doctoral studies on asymmetric organocatalysis, focusing particularly on unconventional axial chirality. In February 2017 he received the "Spada Award" for Ph.D. students who have distinguished themselves in productivity, innovation and scientific independence. Two months later, he completed his Ph.D. and is currently working as a postdoc at the Department of Industrial Chemistry at the University of Bologna.

作者簡介(中文翻譯)

尼科拉·迪·伊奧里奧於1989年出生。在意大利博洛尼亞大學學習期間，他曾在美國洛杉磯加州大學（UCLA）留學一年，並於2013年10月以優異成績（cum laude）畢業於工業化學。隨後，他立即開始了有關不對稱有機催化的博士研究，特別專注於非常規的軸向手性。2017年2月，他獲得了「斯帕達獎」，該獎項頒發給在生產力、創新和科學獨立性方面表現突出的博士生。兩個月後，他完成了博士學位，目前在博洛尼亞大學工業化學系擔任博士後研究員。

類似商品