Bioreactors: Animal Cell Culture Control for Bioprocess Engineering
暫譯: 生物反應器：動物細胞培養控制於生物製程工程
Saha, Goutam, Barua, Alok, Sinha, Satyabroto
- 出版商: CRC
- 出版日期: 2019-06-04
- 售價: $6,400
- 貴賓價: 9.5 折 $6,080
- 語言: 英文
- 頁數: 136
- 裝訂: Hardcover - also called cloth, retail trade, or trade
- ISBN: 1138371750
- ISBN-13: 9781138371750
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商品描述
Bioreactors: Animal Cell Culture Control for Bioprocess Engineering presents the design, fabrication, and control of a new type of bioreactor meant especially for animal cell line culture. The new bioreactor, called the "see-saw bioreactor," is ideal for the growth of cells with a sensitive membrane. The see-saw bioreactor derives its name from its principle of operation in which liquid columns in either limb of the reactor alternately go up and down. The working volume of the reactor is small, to within 15 L. However, it can easily be scaled up for large production in volume of cell mass in the drug and pharmaceutical industries.
The authors describe the principle of operation of the see-saw bioreactor and how to automatically control the bioprocess. They discuss different control strategies as well as the thorough experimental research they conducted on this prototype bioreactor in which they applied a time delay control for yield maximization. To give you a complete understanding of the design and development of the see-saw bioreactor, the authors cover the mathematical model they use to describe the kinetics of fermentation, the genetic algorithms used for deriving the optimal time trajectories of the bioprocess variables, and the corresponding control inputs for maximizing the product yield. One chapter is devoted to the application of time delay control. Following a description of the bioreactor's working setup in the laboratory, the authors sum up their investigation and define the future scope of work in terms of design, control, and software sensors.商品描述(中文翻譯)
生物反應器：動物細胞培養控制於生物製程工程介紹了一種新型生物反應器的設計、製造和控制，特別針對動物細胞系培養。這種新生物反應器稱為「跷跷板生物反應器」，非常適合於具有敏感膜的細胞生長。跷跷板生物反應器的名稱源於其運作原理，即反應器兩側的液柱交替上下運動。反應器的工作容量小，限制在15公升以內。然而，它可以輕鬆擴大以滿足藥物和製藥行業中細胞質量的大規模生產需求。
作者描述了跷跷板生物反應器的運作原理以及如何自動控制生物製程。他們討論了不同的控制策略，以及他們在這個原型生物反應器上進行的徹底實驗研究，並應用了時間延遲控制以最大化產量。
為了讓您全面了解跷跷板生物反應器的設計和開發，作者涵蓋了他們用來描述發酵動力學的數學模型、用於推導生物製程變數最佳時間軌跡的遺傳演算法，以及相應的控制輸入以最大化產品產量的內容。其中一章專門討論時間延遲控制的應用。在描述生物反應器在實驗室的工作設置後，作者總結了他們的調查結果，並定義了未來在設計、控制和軟體感測器方面的工作範疇。
作者簡介
Alok Barua received his bachelor of technology in instrumentation and electronics engineering, master of electronics and telecommunication engineering, and PhD in electrical engineering from Jadavpur University and Indian Institute of Technology (IIT) Kharagpur in 1977, 1980, and 1992, respectively. He is a full professor in the Department of Electrical Engineering, IIT Kharagpur. With more than 30 years of teaching experience at IIT, he has published many papers in his teaching and research areas, including instrumentation, bioreactor design and control, testing and fault diagnosis of analog and mixed-signal circuits, and image processing. He has supervised several MS theses and two PhD theses on bioreactor control and instrumentation. He also holds a patent for the design of the see-saw bioreactor and is a senior member of IEEE.
Goutam Saha earned his BE in electrical engineering, his ME in electronics and telecommunication engineering, and his PhD in electrical engineering from Bengal Engineering and Science University (formerly known as B.E. College) and IIT Kharagpur in 1984, 1989, and 1999, respectively. He worked as a postdoctoral research fellow at Ben Gurion University, Israel, from January to August 2002. He is currently a full professor in the Department of Information Technology, North-Eastern Hill University, Shillong, India. He has more than 25 years of teaching experience in various engineering colleges including the National Institute of Technology (Durgapur), the National Institute of Technical Teachers Training and Research (Kolkata), and other government engineering colleges of West Bengal.
Satyabroto Sinha (deceased) earned a PhD in electrical engineering from the Indian Institute of Technology (IIT) Kharagpur. He taught electrical engineering at IIT Kharagpur from December 1963 to May 2005 (professor, 1982-2002; professor emeritus, 2002-2005). He advised 13 doctoral students, coauthored several books, and published approximately 60 conference and journal papers, nationally and internationally. His area of specialization was instrumentation and control. He was a national coordinator for the Technology Development Mission on Communication, Networking and Intelligent Automation for the Government of India from 1995 to 2000 and was a senior member of the Institute of Electrical and Electronics Engineers and a chartered engineer and fellow of the Institution of Engineers (India).
作者簡介(中文翻譯)
阿洛克·巴魯阿（Alok Barua）於1977年、1980年和1992年分別在賈達布爾大學（Jadavpur University）和印度理工學院（IIT）卡哈格普爾獲得儀器與電子工程學士學位、電子與電信工程碩士學位及電氣工程博士學位。他是IIT卡哈格普爾電氣工程系的正教授。在IIT擁有超過30年的教學經驗，他在儀器、反應器設計與控制、類比與混合信號電路的測試與故障診斷以及影像處理等教學和研究領域發表了許多論文。他指導了幾篇碩士論文和兩篇關於反應器控制與儀器的博士論文。他還擁有搖擺反應器設計的專利，並且是IEEE的資深會員。
古塔姆·薩哈（Goutam Saha）於1984年、1989年和1999年分別在孟加拉工程與科學大學（Bengal Engineering and Science University，前稱B.E. College）和IIT卡哈格普爾獲得電氣工程學士學位、電子與電信工程碩士學位及電氣工程博士學位。他於2002年1月至8月在以色列本古里安大學擔任博士後研究員。目前，他是印度西隆的東北山大學（North-Eastern Hill University）資訊技術系的正教授。他在多所工程學院擁有超過25年的教學經驗，包括國立技術學院（Durgapur）、國立技術教師培訓與研究所（Kolkata）及西孟加拉的其他政府工程學院。
薩蒂亞布羅托·辛哈（Satyabroto Sinha）（已故）於印度理工學院（IIT）卡哈格普爾獲得電氣工程博士學位。他於1963年12月至2005年5月在IIT卡哈格普爾教授電氣工程（教授，1982-2002；名譽教授，2002-2005）。他指導了13位博士生，合著了幾本書籍，並在國內外發表了約60篇會議和期刊論文。他的專業領域是儀器與控制。他曾於1995年至2000年擔任印度政府通信、網絡與智能自動化技術發展任務的全國協調員，並且是電氣與電子工程師學會的資深會員，以及印度工程師學會的特許工程師和院士。
