Handbook of Mitochondrial Dysfunction
暫譯: 線粒體功能障礙手冊
Ahmad, Shamim I.
- 出版商: CRC
- 出版日期: 2019-06-06
- 售價: $7,820
- 貴賓價: 9.5 折 $7,429
- 語言: 英文
- 頁數: 480
- 裝訂: Hardcover - also called cloth, retail trade, or trade
- ISBN: 1138336084
- ISBN-13: 9781138336087
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相關主題
商品描述
Mitochondria produce the chemical energy necessary for eukaryotic cell functions; hence mitochondria are an essential component of health, playing roles in both disease and aging. More than 80 human diseases and syndromes are associated with mitochondrial dysfunction; this book focuses upon diseases linked to these ubiquitous organelles. Accumulation of mitochondrial DNA damage results in mitochondrial dysfunction through two main pathways. Mutation in mitochondrial DNA causes diseases such as Kearns-Sayre syndrome and Pearson syndrome. Mutation in chromosomal DNA causes diseases such as Parkinson's disease and schizophrenia. These and many other diseases will be reviewed in this book.
Key selling features:
- Presents the detailed structure of mitochondria, mitochondrial function, roles of oxidants and antioxidants in mitochondrial dysfunction
- Includes summary of both causes and effects of these diseases
- Discusses current and potential future therapies for mitochondrial dysfunction diseases
- Explores a wide variety of diseases caused by dysfunctional mitochondria
- Covers animal animal studies
商品描述(中文翻譯)
線粒體產生真核細胞功能所需的化學能量，因此線粒體是健康的重要組成部分，並在疾病和衰老中扮演著角色。超過80種人類疾病和綜合症與線粒體功能障礙有關；本書專注於與這些無處不在的細胞器相關的疾病。線粒體DNA損傷的累積通過兩條主要途徑導致線粒體功能障礙。線粒體DNA的突變會導致如Kearns-Sayre綜合症和Pearson綜合症等疾病。染色體DNA的突變則會導致如帕金森病和精神分裂症等疾病。本書將回顧這些及其他許多疾病。
主要銷售特點：
- 提供線粒體的詳細結構、線粒體功能、氧化劑和抗氧化劑在線粒體功能障礙中的作用
- 包含這些疾病的成因和影響的總結
- 討論目前及未來潛在的線粒體功能障礙疾病療法
- 探索由功能障礙的線粒體引起的各種疾病
- 涵蓋動物研究
作者簡介
Shamim I. Ahmad earned his
Master's degree in Botany from
Patna University, Bihar, India, and
his PhD in Molecular Genetics
from Leicester University, England.
He then joined Nottingham
Polytechnic as a grade 1 lecturer and subsequently was
promoted to the post of Senior Lecturer. Ahmad now
spends much of his time producing/writing medical
books. For more than three decades he researched different
areas of molecular biology/genetics including thymineless
death in bacteria, genetic control of nucleotide
catabolism, development of anti-AIDs drug, control of
microbial infection of burns, phages of thermophilic bacteria,
and microbial flora of Chernobyl after the nuclear
power station accident. But his main interest is DNA
damage and repair specifically by near-ultraviolet light
mostly through the photolysis of biological compounds,
production of reactive oxygen species, and their implications
on human health including skin cancer. He also
investigates near-ultraviolet photolysis of non-biological
compounds such as 8-metoxypsoralen, mitomycin C, and
their importance in psoriasis treatment and in Fanconi
anemia. He has collaborated with the University of
Osaka, Japan, and he and his colleagues were able to
show that a number of naturally occurring enzymes were
able to scavenge the reactive oxygen species.
In 2003 he received a prestigious Asian Jewel Award
in Britain for Excellence in Education. His long time ambition
to produce medical books started in 2007 and since
then he has published Molecular mechanisms of Fanconi
Anemia, Molecular Mechanisms of Xeroderma Pigmentosum;
Molecular Mechanisms of Cockayne Syndrome;
Molecular Mechanisms of Ataxia Telangiectasia; Diseases
of DNA repair; Neurodegenerative diseases; Diabetes: an
Old Disease a New Insight, Obesity: a Practical Guide,
Thyroid: Basic Science and Clinical Practice, and Ultraviolet
light in Human Health, diseases and environment; also
as a co-author the book on Diabetes: A comprehensive
Treatise for patients and Caregivers. His most recent books
are Reactive Oxygen Species in Biology and Human Health
and Aging: Exploring a Complex Phenomenon.
作者簡介(中文翻譯)
Shamim I. Ahmad 獲得了印度比哈爾邦帕特納大學的植物學碩士學位，以及英國萊斯特大學的分子遺傳學博士學位。隨後，他加入了諾丁漢理工學院擔任一級講師，並隨後晉升為高級講師。Ahmad 現在花費大量時間撰寫醫學書籍。在過去三十多年中，他研究了分子生物學/遺傳學的不同領域，包括細菌中的無胸腺素死亡、核苷酸分解代謝的遺傳控制、抗艾滋病藥物的開發、燒傷的微生物感染控制、嗜熱細菌的噬菌體，以及切爾諾貝爾核電站事故後的微生物群落。但他最主要的興趣是 DNA 損傷及修復，特別是近紫外光對生物化合物的光解、活性氧物種的產生及其對人類健康的影響，包括皮膚癌。他還研究了近紫外光對非生物化合物的光解，如 8-美克索噻啉、米托黴素 C，以及它們在銀屑病治療和范可尼貧血中的重要性。他曾與日本大阪大學合作，他和他的同事們能夠證明多種天然酶能夠清除活性氧物種。2003 年，他在英國獲得了著名的亞洲珠寶獎，以表彰其在教育方面的卓越成就。他長期以來的醫學書籍出版夢想始於 2007 年，自那時以來，他已出版了《范可尼貧血的分子機制》、《乾燥症的分子機制》、《科克斯綜合症的分子機制》、《小腦性血管擴張症的分子機制》、《DNA 修復疾病》、《神經退行性疾病》、《糖尿病：舊病的新見解》、《肥胖：實用指南》、《甲狀腺：基礎科學與臨床實踐》，以及《紫外光在人類健康、疾病與環境中的作用》等書籍；他還作為合著者參與了《糖尿病：患者與護理者的綜合論著》。他最近的書籍包括《生物學與人類健康中的活性氧物種》和《衰老：探索一個複雜的現象》。
