Genetic Analysis of Complex Disease
暫譯: 複雜疾病的基因分析
Scott, William K., Ritchie, Marylyn D.
- 出版商: Wiley
- 出版日期: 2021-12-06
- 售價: $4,450
- 貴賓價: 9.5 折 $4,228
- 語言: 英文
- 頁數: 336
- 裝訂: Quality Paper - also called trade paper
- ISBN: 1118123913
- ISBN-13: 9781118123911
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商品描述
An up-to-date and complete treatment of the strategies, designs and analysis methods for studying complex genetic disease in human beings
In the newly revised Third Edition of Genetic Analysis of Complex Diseases, a team of distinguished geneticists delivers a comprehensive introduction to the most relevant strategies, designs and methods of analysis for the study of complex genetic disease in humans. The book focuses on concepts and designs, thereby offering readers a broad understanding of common problems and solutions in the field based on successful applications in the design and execution of genetic studies.
This edited volume contains contributions from some of the leading voices in the area and presents new chapters on high-throughput genomic sequencing, copy-number variant analysis and epigenetic studies. Providing clear and easily referenced overviews of the considerations involved in genetic analysis of complex human genetic disease, including sampling, design, data collection, linkage and association studies and social, legal and ethical issues.
Genetic Analysis of Complex Diseases also provides:
- A thorough introduction to study design for the identification of genes in complex traits
- Comprehensive explorations of basic concepts in genetics, disease phenotype definition and the determination of the genetic components of disease
- Practical discussions of modern bioinformatics tools for analysis of genetic data
- Reflecting on responsible conduct of research in genetic studies, as well as linkage analysis and data management
- New expanded chapter on complex genetic interactions
This latest edition of Genetic Analysis of Complex Diseases is a must-read resource for molecular biologists, human geneticists, genetic epidemiologists and pharmaceutical researchers. It is also invaluable for graduate students taking courses in statistical genetics or genetic epidemiology.
商品描述(中文翻譯)
複雜疾病的遺傳分析
針對人類複雜遺傳疾病研究的策略、設計和分析方法的最新完整處理
在新修訂的第三版複雜疾病的遺傳分析中，一組傑出的遺傳學家提供了對人類複雜遺傳疾病研究中最相關的策略、設計和分析方法的全面介紹。本書專注於概念和設計，從而為讀者提供基於成功應用於遺傳研究設計和執行的領域中常見問題和解決方案的廣泛理解。
這本編輯的著作包含了該領域一些領先聲音的貢獻，並呈現了有關高通量基因組測序、拷貝數變異分析和表觀遺傳學研究的新章節。提供了對於複雜人類遺傳疾病的遺傳分析中涉及的考量的清晰且易於參考的概述，包括取樣、設計、數據收集、連鎖和關聯研究以及社會、法律和倫理問題。
複雜疾病的遺傳分析還提供了：
- 針對複雜性狀中基因識別的研究設計的徹底介紹
- 對遺傳學基本概念、疾病表型定義及疾病遺傳成分確定的全面探討
- 對現代生物資訊學工具在遺傳數據分析中的實用討論
- 反思遺傳研究中的負責任研究行為，以及連鎖分析和數據管理
- 有關複雜遺傳互作的新擴展章節
這本最新版本的複雜疾病的遺傳分析是分子生物學家、人類遺傳學家、遺傳流行病學家和藥物研究人員必讀的資源。對於修習統計遺傳學或遺傳流行病學課程的研究生來說，它也是不可或缺的。
作者簡介
William K. Scott, PhD, is Professor at the University of Miami Leonard M. Miller School of Medicine where he teaches design and analysis of human genomic studies. He has authored over 200 peer-reviewed articles on the genetic epidemiology of complex traits.
Marylyn D. Ritchie, PhD, is Professor in the Department of Genetics at the University of Pennsylvania, Perelman School of Medicine. She is also the Director of the Center for Translational Bioinformatics in the Institute for Biomedical Informatics. She has authored over 350 peer-reviewed articles on statistical genetics, translational bioinformatics and biomedical informatics.
作者簡介(中文翻譯)
威廉·K·史考特（William K. Scott, PhD）是邁阿密大學萊昂納德·M·米勒醫學院的教授，教授人類基因組研究的設計與分析。他已發表超過200篇有同行評審的文章，專注於複雜性狀的遺傳流行病學。
瑪麗琳·D·瑞奇（Marylyn D. Ritchie, PhD）是賓夕法尼亞大學佩雷爾曼醫學院遺傳學系的教授。她同時也是生物醫學資訊研究所轉譯生物資訊中心的主任。她已發表超過350篇有同行評審的文章，專注於統計遺傳學、轉譯生物資訊學和生物醫學資訊學。
