Rna: Computational Methods for Structure, Kinetics, and Rational Design: Volume One
暫譯: RNA：結構、動力學與理性設計的計算方法：第一卷
Clote, Peter G.
- 出版商: CRC
- 出版日期: 2025-03-19
- 售價: $4,170
- 貴賓價: 9.5 折 $3,962
- 語言: 英文
- 頁數: 284
- 裝訂: Hardcover - also called cloth, retail trade, or trade
- ISBN: 1032496649
- ISBN-13: 9781032496641
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商品描述
Comprising two volumes, RNA: Computational Methods for Structure, Kinetics, and Rational Design is a comprehensive treatment of computational methods concerning the secondary structure, folding kinetics and rational design of RNA.
Volume One concerns energy and structure and is divided into five chapters. Chapter 1 describes the molecular structure of ribonucleotides, basic classes of RNA and databases of RNA sequences and structure. Chapter 2 presents the basic concepts of thermodynamics, since thermodynamics-based algorithms constitute an essential tool in rational design of functional RNA molecules. Chapter 3 describes how empirical secondary structure energy parameters are obtained from ultraviolet absorbance experiments via Van 't Hoff plots and least-squares data fitting. Chapter 4 describes methods from combinatorics, automata and formal language theory, and complex analysis. Chapter 5 provides an overview of some of the most important thermodynamics-based algorithms related to secondary structure. Exercises and solutions are provided at the end of every chapter and source code is available at the book's website (sometimes including computer programs using Python and extensions Numpy and Scipy).
This book provides the nuts, bolts and tools to take the next steps in computational RNA synthetic biology. It is perfect for advanced undergraduate, graduate and post-graduate readers having analytical interests and skills from areas such as physical chemistry, physics, mathematics, computer science, and statistics.
商品描述(中文翻譯)
本書《RNA: Computational Methods for Structure, Kinetics, and Rational Design》共分為兩卷，是關於RNA的二級結構、摺疊動力學和理性設計的計算方法的全面探討。
第一卷涉及能量和結構，分為五章。第一章描述了核糖核苷酸的分子結構、RNA的基本類別以及RNA序列和結構的數據庫。第二章介紹了熱力學的基本概念，因為基於熱力學的算法是功能性RNA分子理性設計的重要工具。第三章描述了如何通過紫外吸收實驗獲得經驗性二級結構能量參數，這些參數是通過Van 't Hoff圖和最小二乘數據擬合獲得的。第四章介紹了來自組合數學、自動機和形式語言理論以及複分析的方法。第五章概述了一些與二級結構相關的最重要的基於熱力學的算法。每章末尾提供了練習題和解答，並且書籍網站上提供了源代碼（有時包括使用Python及其擴展Numpy和Scipy的計算機程序）。
本書提供了進一步探索計算RNA合成生物學所需的基本工具和資源。非常適合具有分析興趣和技能的高年級本科生、研究生及博士後讀者，這些讀者的背景可能來自物理化學、物理學、數學、計算機科學和統計學等領域。
作者簡介
Peter Clote is Professor of Biology at Boston College, USA, with courtesy appointment in Computer Science. He is an international expert in computational biology, with focus on RNA. Earning B.Sc. and PhD degrees in mathematics from MIT and Duke University, as well as a Doctorat d'Etat from Université Paris 7, Clote has held faculty positions in mathematics, computer science, and biology departments at universities in France (Paris 7), the United States (BC), and Germany (LMU). As Gentzen Chair of Computer Science at the University of Munich (LMU), he played a leading role in the establishment of the bioinformatics graduate program there. He has held visiting positions at MIT, the Max Planck Institute in Berlin, CWI in Amsterdam, Ecole Polytechnique and Université Paris-Sud (as Digiteo Chair of Excellence in Computer Science), and other universities. Clote started and co-organized the MIT Bioinformatics Seminar over a period of ten years, he has served as Associate Editor of the Journal of Mathematical Biology, on the editorial board of four other journals, and has co-written two books, co-edited four books, and published around 100 research articles in computational biology, mathematics, and theoretical computer science. His research was and continues to be supported by NSF divisions of mathematical sciences, biology, and computer science, as well as by Digiteo (France) and DFG (Germany). He has received a Fulbright and a Guggenheim fellowship, as well as receiving an Alexander von Humboldt Foundation research grant.
作者簡介(中文翻譯)
彼得·克洛特（Peter Clote）是美國波士頓學院（Boston College）生物學教授，並兼任計算機科學的職位。他是計算生物學的國際專家，專注於RNA。克洛特在麻省理工學院（MIT）和杜克大學（Duke University）獲得數學的學士和博士學位，並在巴黎第七大學（Université Paris 7）獲得國家博士學位（Doctorat d'Etat）。他曾在法國（巴黎第七大學）、美國（波士頓學院）和德國（慕尼黑大學LMU）的數學、計算機科學和生物學系擔任教職。作為慕尼黑大學（LMU）計算機科學的根岑講座教授（Gentzen Chair），他在那裡的生物信息學研究生項目的建立中發揮了重要作用。他曾在麻省理工學院、柏林的馬克斯·普朗克研究所、阿姆斯特丹的CWI、法國的高等工藝學院（Ecole Polytechnique）和巴黎南大學（Université Paris-Sud，作為計算機科學的Digiteo卓越講座教授）以及其他大學擔任訪問職位。克洛特在十年間創辦並共同組織了麻省理工學院的生物信息學研討會，他曾擔任《數學生物學期刊》（Journal of Mathematical Biology）的副編輯，並在其他四本期刊的編輯委員會中任職，還共同撰寫了兩本書，編輯了四本書，並在計算生物學、數學和理論計算機科學領域發表了約100篇研究文章。他的研究曾獲得美國國家科學基金會（NSF）數學科學、生物學和計算機科學部門的支持，以及法國的Digiteo和德國的DFG的資助。他曾獲得富布賴特獎學金（Fulbright）和古根海姆獎學金（Guggenheim），並獲得亞歷山大·馮·洪堡基金會的研究資助。
