Inhalation Aerosols: Physical and Biological Basis for Therapy, Third Edition
暫譯: 吸入氣霧劑：治療的物理與生物基礎（第三版）

吸入氣霧劑仍然是幾種疾病成功肺部治療的基礎，近年來治療策略和技術範圍顯著演變。

因此，本書第三版採取了新的方法，以反映技術與其應用的緊密整合。在簡要介紹適用於氣霧吸入的一般考量後，本書的核心部分專注於疾病和治療藥物，以說明特定技術的應用。

最後的整合策略部分總結了針對疾病目標和藥物產品的應用要點。

Anthony J. Hickey, PhD, DSc, is Distinguished RTI Fellow, at the Research Triangle Institute (2010-present), Emeritus Professor of Molecular Pharmaceutics of the Eshelman School of Pharmacy (1993-2010), and Adjunct Professor Biomedical Engineering in the School of Medicine at the University of North Carolina at Chapel Hill. He obtained PhD (1984) and DSc (2003) degrees in pharmaceutical sciences from Aston University, Birmingham, United Kingdom, following postdoctoral positions at the University of Kentucky (1984-1988). Dr. Hickey then joined the faculty at the University of Illinois at Chicago (1988-1993). In 1990, he received the Association of Pharmaceutical Scientists (AAPS) Young Investigator Award in Pharmaceutics and Pharmaceutical Technology. He is a Fellow of the Royal Society of Biology (2000), the American Association of Pharmaceutical Scientists (2003), the American Association for the Advancement of Science (2005), and the Royal Society of Biology (2017). He received the Research Achievement Award of the Particulate Presentations and Design Division of the Powder Technology Society of Japan (2012), the Distinguished Scientist Award of the American Association of Indian Pharmaceutical Scientists (2013), the David W. Grant Award in Physical Pharmacy of the American Association of Pharmaceutical Scientists (2015), the Thomas T. Mercer Joint Prize for Excellence in Inhaled Medicines and Pharmaceutical Aerosols of the American Association for Aerosol Research and the International Society for Aerosols in Medicine (2017). He has published numerous papers and chapters (over 250) in the pharmaceutical and biomedical literature, one of which received the AAPS Meritorious Manuscript Award in 2001. He has edited five texts on pharmaceutical inhalation aerosols and co-authored three others on pharmaceutical process engineering, pharmaceutical particulate science, and pharmaco complexity. He holds 25 U.S. patents on a variety of inhaler device technologies, and pulmonary and oral drug delivery formulation technologies. He is founder (1997, and formerly president and CEO, 1997-2013) of Cirrus Pharmaceuticals, Inc., which was acquired by Kemwell Pharma in 2013; founder (2001, and formerly CSO, 2002-2007) of Oriel Therapeutics, Inc, which was acquired by Sandoz in 2010; and founder and CEO of Astartein, Inc. (2013-present). He is a member of the Pharmaceutical Dosage Forms Expert Committee of the United States Pharmacopeia (USP, 2010-2015, Chair of the Subcommittee on Aerosols), and formerly Chair of the Aerosols Expert Committee of the USP (2005-2010). Dr. Hickey conducts a multidisciplinary research program in the field of pulmonary drug and vaccine delivery for treatment and prevention of a variety of diseases.

Heidi M. Mansour, PhD, RPh, is a tenured Associate Professor of Pharmaceutical Sciences in the College of Pharmacy with joint faculty appointments in the BIO5 Research Institute and the College of Medicine in the Division of Translational and Regenerative Medicine at The University of Arizona (UA) in Tucson, Arizona. Dr. Mansour has faculty member affiliations in the UA Institute of the Environment, and the UA NCI Comprehensive Cancer Center. She lectures in the BS Pharmaceutical Sciences undergraduate program, the Pharm.D. professional program and in the Pharmaceutics and Pharmacokinetics track of the graduate program at The University of Arizona. In addition to teaching, Dr. Mansour serves as Faculty Advisor in the Pharm.D./PhD Dual Degree Joint Program and Director of the Pharmaceutics and Pharmacokinetics track in the Pharmaceutical Sciences graduate program in The UA College of Pharmacy. Dr. Mansour has published over 80 peer-reviewed scientific journal papers, 9 book chapters, 2 edited books, and over 100 scientific conference abstracts. She serves on the editorial advisory boards of the the Royal Society of Chemistry Molecular Systems Design & Engineering, APhA/FIP Journal of Pharmaceutical Sciences, and Pharmaceutical Technology.

Dr. Mansour is an annual Faculty Instructor at ISAM (International Society of Aerosols in Medicine) Aerosol School, instructor in two online webinars on inhalation aerosol drug delivery, and instructor in Buchi Advanced Spray Drying short courses. She was recently Co-Chair of the Drug Delivery: New Devices & Emerging Therapies Group in (ISAM, and has been an expert member of the National Institutes of Health (NIH) NICHD U.S. Pediatric Formulations Initiative New Drug Delivery Systems Aerosols Working Group for several years. Dr. Mansour currently serves on the Drug/Device Discovery and Development (DDDD) Committee of the American Thoracic Society (ATS). She regularly serves as an expert reviewer for scientific journals and grant funding agencies including NIH study sections; Department of Defense (DOD) study panels; National Science Foundation (NSF) study panels; the American Association for the Advancement of Science (AAAS); Catalent Drug Delivery Institute; and international funding agencies such as the German-Israeli Foundation, German International Exchange Service (DAAD), Cochrane Airways Group of the National Health Service (London, England), Engineering and Physical Sciences Research Council (London, England), PRESTIGE Postdoc Fellowship Programme of the European Commission (Paris, France), and the Biomedical Innovation Program of the French National Research Agency (Paris, France).

In addition to serving on NSF study panels, NIH study sections, and international study panels in the European Union and Great Britain, her innovative research program continuously attracts competitive funding awards from federal sources (NIH, NSF, FDA, DOD) and the pharmaceutical industry. In addition to lecturing in the BS Pharmaceutical Sciences undergraduate, PhD graduate, and Pharm. D. professional programs, Dr. Mansour leads her research labs where she trains postdoctoral scholars, visiting scholars, visiting professors, graduate students, Pharm. D. student researchers, and physician-scientist (MD/PhD) fellows. As Major Professor and mentor, her research program has successfully graduated several PhDs. Her innovative research program has produced assistant professors employed at research universities in the United States and in the Republic of South Korea, and senior research scientists employed at major pharmaceutical companies in the United States.

Dr. Mansour is an active, long-time member of several scientific organizations and elected member to honor societies, including the Sigma Xi Scientific Research Honor Society, Rho Chi Pharmaceutical Honor Society, and Golden Key International Honor Society. As a registered pharmacist for over 20 years, she earned her BS in pharmacy with honors and distinction, a PhD minor in advanced physical and interfacial chemistry (Department of Chemistry), and a PhD major in drug delivery/pharmaceutics (School of Pharmacy) from the University of Wisconsin-Madison. Also at the University of Wisconsin-Madison, she was a clinical instructor for a few years. Having completed postdoctoral fellowships at the University of Wisconsin-Madison and at the University of North Carolina (UNC)-Chapel Hill, she was awarded the UNC-Chapel Hill Postdoctoral Award for Research Excellence from the Office of the Vice-Chancellor, the AAPS Postdoctoral Fellow Award in Research Excellence, and the PhRMA Foundation Postdoctoral Fellowship Award. As an Instructor, she served on the Graduate Faculty at UNC-Chapel Hill.

安東尼·J·希基（Anthony J. Hickey），博士，DSc，是研究三角洲研究所（Research Triangle Institute）的傑出RTI研究員（2010年至今），曾任埃舍爾曼藥學院（Eshelman School of Pharmacy）分子藥劑學名譽教授（1993-2010），以及北卡羅來納大學教堂山分校醫學院生物醫學工程的兼任教授。他於1984年獲得英國伯明翰阿斯頓大學（Aston University）藥學科學博士學位，並於2003年獲得DSc學位，隨後在肯塔基大學（University of Kentucky）擔任博士後研究員（1984-1988）。希基博士於1988年加入伊利諾伊大學芝加哥分校（University of Illinois at Chicago）任教，並於1990年獲得美國藥學科學協會（AAPS）藥劑學與藥學技術青年研究員獎。他是皇家生物學會（Royal Society of Biology，2000）、美國藥學科學協會（American Association of Pharmaceutical Scientists，2003）、美國科學促進協會（American Association for the Advancement of Science，2005）及皇家生物學會（2017）的院士。他獲得日本粉體技術學會（Powder Technology Society of Japan）顆粒呈現與設計部門的研究成就獎（2012）、美國印度藥學科學協會（American Association of Indian Pharmaceutical Scientists）傑出科學家獎（2013）、美國藥學科學協會（AAPS）物理藥學大衛·W·格蘭特獎（2015）、美國氣溶膠研究協會（American Association for Aerosol Research）及國際醫學氣溶膠學會（International Society for Aerosols in Medicine）托馬斯·T·梅瑟卓越獎（2017）。他在藥學和生物醫學文獻中發表了超過250篇論文和章節，其中一篇於2001年獲得AAPS優秀手稿獎。他編輯了五本有關藥物吸入氣霧劑的書籍，並共同撰寫了三本有關藥物工藝工程、藥物顆粒科學和藥物複雜性的書籍。他擁有25項美國專利，涵蓋各種吸入裝置技術以及肺部和口服藥物傳遞配方技術。他是Cirrus Pharmaceuticals, Inc.的創始人（1997年，並曾擔任總裁兼首席執行官，1997-2013），該公司於2013年被Kemwell Pharma收購；Oriel Therapeutics, Inc.的創始人（2001年，並曾擔任首席科學官，2002-2007），該公司於2010年被Sandoz收購；以及Astartein, Inc.的創始人兼首席執行官（2013年至今）。他是美國藥典（USP）藥物劑型專家委員會的成員（2010-2015，氣霧劑小組委員會主席），並曾擔任USP氣霧劑專家委員會主席（2005-2010）。希基博士在肺部藥物和疫苗傳遞領域進行多學科研究，旨在治療和預防各種疾病。

海蒂·M·曼索爾（Heidi M. Mansour），博士，註冊藥師，是亞利桑那大學（The University of Arizona，UA）藥學院的終身副教授，並在BIO5研究所和醫學院的轉化與再生醫學部門擔任聯合教職。曼索爾博士在UA環境研究所和UA國家癌症研究所綜合癌症中心擔任教職成員。她在亞利桑那大學的藥學科學學士學位（BS Pharmaceutical Sciences）本科課程、藥學博士（Pharm.D.）專業課程以及研究生課程的藥劑學和藥物動力學專業中授課。除了教學外，曼索爾博士還擔任藥學博士/博士雙學位聯合課程的教學顧問，以及UA藥學院藥劑學和藥物動力學專業的主任。曼索爾博士已發表超過80篇經過同行評審的科學期刊論文、9章書籍、2本編輯書籍以及超過100篇科學會議摘要。她在皇家化學學會的《分子系統設計與工程》（Molecular Systems Design & Engineering）、美國藥學會/國際藥學聯合會的《藥學科學期刊》（Journal of Pharmaceutical Sciences）和《藥學技術》（Pharmaceutical Technology）的編輯顧問委員會中任職。

曼索爾博士是ISAM（國際醫學氣溶膠學會）氣溶膠學校的年度教學講師，並在兩個有關吸入氣霧劑藥物傳遞的線上研討會中擔任講師，還在Buchi高級噴霧乾燥短期課程中擔任講師。她最近擔任ISAM的藥物傳遞：新裝置與新興療法小組的共同主席，並且多年來一直是美國國立衛生研究院（NIH）NICHD美國兒科配方倡議新藥物傳遞系統氣霧劑工作組的專家成員。曼索爾博士目前在美國胸科學會（ATS）的藥物/裝置發現與開發（DDDD）委員會任職。她定期擔任科學期刊和資助機構的專家審稿人，包括NIH研究小組、國防部（DOD）研究小組、國家科學基金會（NSF）研究小組、美國科學促進協會（AAAS）、Catalent藥物傳遞研究所，以及德國-以色列基金會、德國國際交流服務（DAAD）、英國國民健康服務的Cochrane Airways Group、英國倫敦的工程與物理科學研究委員會、歐洲委員會的PRESTIGE博士後獎學金計劃和法國國家研究機構的生物醫學創新計劃等國際資助機構。

除了在NSF研究小組、NIH研究小組和歐盟及英國的國際研究小組任職外，她的創新研究計劃不斷吸引來自聯邦資源（NIH、NSF、FDA、DOD）和製藥行業的競爭性資助獎項。除了在藥學科學學士學位、博士研究生和藥學博士專業課程中授課外，曼索爾博士還領導她的研究實驗室，培訓博士後學者、訪問學者、訪問教授、研究生、藥學博士學生研究員和醫生-科學家（MD/PhD）獎學金獲得者。作為主要教授和導師，她的研究計劃成功培養了多位博士畢業生。她的創新研究計劃已培養出在美國和南韓的研究大學任職的助理教授，以及在美國主要製藥公司任職的高級研究科學家。

曼索爾博士是多個科學組織的活躍成員，並當選為榮譽學會的成員，包括Sigma Xi科學研究榮譽學會、Rho Chi藥學榮譽學會和Golden Key國際榮譽學會。作為一名註冊藥師，她擁有超過20年的經驗，並以優異的成績獲得威斯康辛大學麥迪遜分校的藥學學士學位、進階物理與界面化學的博士學位（化學系）以及藥物傳遞/藥劑學的博士學位（藥學院）。她在威斯康辛大學麥迪遜分校擔任臨床講師數年。完成在威斯康辛大學麥迪遜分校和北卡羅來納大學（UNC）教堂山分校的博士後研究後，她獲得了UNC教堂山分校副校長辦公室頒發的博士後研究卓越獎、AAPS博士後研究卓越獎和PhRMA基金會博士後獎學金。作為講師，她在UNC教堂山分校的研究生教學中任職。