Skin 3-D Models and Cosmetics Toxicity
暫譯: 皮膚三維模型與化妝品毒性

Professor AB Pant is a seasoned toxicologist with over thirty years of active research career. Presently serving as 'Senior Principal Scientist' at CSIR-Indian Institute of Toxicology Research, Lucknow, and also a 'Professor' of Academy of Scientific & Innovative Research, an Institution of National Importance set up by the Act of Parliament, Government of India. In the scientific fraternity, Professor Pant is renowned for his elegant research on the application of human stem cells and iPSCs in developmental neurotoxicity and establishing the number of in vitro model systems as an alternative to laboratory animals for biomedical research. He also founded a new discipline of "In-Vitro Toxicology" in the country. He also dedicated himself to fostering contemporary science to Post-Graduate, PhD students, researchers, and university teachers. He is a lead GLP inspector for the Government of India, and also serves as an expert for regulatory bodies, such asBIS, CDSCO, NABL, FSSAI, NGCMA, ICMR, DST, Pharmacovigilance, etc. He has won several awards and honors, including Vigyan Ratna Award-2010 (CST UP); Shakuntala Amir Chand Prize-2007 (ICMR); National Bioscience Award-2012 (DBT); Prof. KT Shetty Memorial Oration Award-2017 (Indian Academy of Neurosciences), Toxicology Promotion Award-2018 (National Academy of Sciences, Allahabad), STOX/ASAW Gold Medal (STOX, India), etc. He has been elected Fellow of Academy of Toxicological Sciences, USA, Society of Toxicology, India, Indian Academy of Neurosciences, Academy of Sciences for Animal Welfare, India, Academy of Environmental Biology India, etc. In view of outstanding credibility in toxicology, Professor Pant has been included as a global toxicologist in the 'European and United Kingdom Register of Toxicologists' and has also been conferred the DSc (h. c.) degree by HNB Medical Education University, Dehradun, Uttarakhand, India. He currently serves as Chairman and Member of several National and International Committees/ Boards of Government Institutes and Bodies. He also serves as a member of the editorial board of several reputable journals.

Dr Ashish Dwivedi is graduated from CSIR-Indian Institute of Toxicology Research, Lucknow, India, in the area of Photobiology and Phototoxicology. Thereafter, he enriched himself in the same domain of research as Post-Doctoral Fellow at Israel Institute of Technology, Israel; Colorado University, USA, and Banaras Hindu University, Varanasi, India. Based on his outstanding research experience, he got an opportunity to join back to his parenteral research organization-CSIR-IITR, where he is currently serving as a Scientist in the System Toxicology & Health Risk Assessment Group. In a decade-long research career, Dr Dwivedi has established himself as one among the pioneers in the area of phototoxicity/ photosafety with special reference to the photsafety of therapeutic agents, nanotized phytochemicals, environmental pollutants, etc. Besides the laboratory work, he has also been involved in fostering contemporary science to Post-Graduate, PhD students, researchers, and university teachers. Dr Dwivedi's research efforts have been rewarding in terms of the quantifiable number of research publications in journals of high repute. He has also edited three books for Springer Nature in the area of Photoprotection, Skin Aging, and Neuroprotection. He is a member of various scientific societies, to name a few are- Society of Toxicology, USA, American Society for Photobiology, USA, Indian Photobiology Society, India, Society of Toxicology, India, etc.

Professor Ratan Singh Ray is a Chief Scientist & Head, Photobiology Division at CSIR-Indian Institute of Toxicology Research, Lucknow, India. He is one of the founders who established a new discipline of Photobiology/ Phototoxicity in the country. His active research career of over three decades in the area of Photobiology made him instrumental as a resource person in the Bureau of Indian Standards for the formulation/ revision of several standards for cosmetics and personal health care products. His research group is credited for creating the complete spectrum of UV-A, UV-B and UV-C radiation falling on the earth's surface at latitude- Longitude 26.8467° N, 80.9462° E for over twenty years. Such dedicated and sustained efforts in creating this database have created immense wealth for the scientific fraternity working in this area of research, industries involved in the production and R & D of cosmetic and personal health care products, and regulatory agencies. He has supervised more than a dozen students for PhD, several post-doctoral fellows and post-graduate students. He is also rendering his intellectual inputs and expertise to various scientific societies and government agencies, such as the Bureau of Indian Standards, India, American Society for Photobiology, USA, Indian Photobiology Society, India, Society of Toxicology, India. His research is highly cited in the scientific literature as evidenced by a Google Scholar Score of over 2000 with an H-Index of 28. He is currently coordinating several investigator-driven research grants from different national funding agencies in the country.

Dr Anurag Tripathi is working as Principal Scientist in CSIR-Indian Institute of Toxicology Research. He did his Ph.D from School of Biotechnology, Banaras Hindu University, on Immunomodulatory effects of Prolactin and Growth hormone on macrophages. His work contributes to an in-depth understanding of the immunomodulatory, immunosuppressive effects of common food additives, drugs and cosmetic ingredients. He has also worked on the tumorigenic potential of mycotoxins and the molecular mechanisms leading to skin cancer. Dr Tripathi has over sixteen years of research experience and published 50 articles in peer reviewed international journals such as Immunology, MolecularImmunology, Molecular Aspects of Medicine, Toxicology Letters, ACS Nano, Toxicology and Applied Pharmacology etc. His publications are well cited with an H-index of 25. He is a life member of Indian Nanoscience Society and serves as an editorial board member in several prestigious international journals such as Journal of Immunology & Serum Biology, SM Journal of Nanotechnology and Nanomedicine, Journal of Toxicology and Forensic cases and Austin Immunology.

Dr Atul Kumar Upadhyay received his PhD degree in Life Sciences from National Centre for Biological Sciences (NCBS), Bangalore; Tata Institute of Fundamental Research (TIFR), Mumbai, in 2015. His primary area of research encompasses around in-depth plant genomic analysis and computer simulations for developing database management systems and bioinformatics tools. He started his teaching career as Assistant Professor at Lovely Professional University, Jalandhar, Punjab, India in 2016. Presently, he is serving as Assistant Professor at the Department of Biotechnology, Thapar Institute of Engineering & Technology (TIET), Patiala, Punjab, India. His area of expertise is comparative genomics and bioinformatics, computational biology, molecular modeling of biomolecules and drug designing. Based on his research, he has come up with a good number of research publications in national and international journals of high repute. Besides the research publications, he is also edited one book "Bioinformatics for Agriculture: High-throughput approaches" for Springer Nature. He is an author/co-author in several book chapters in his area of expertise. Presently, he is also serving as an editorial member in a few of the good journals of his area of research.

Dr Shiv Poojan is currently holding the position of Scientist at Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA. He is a research graduate from CSIR-Indian Institute of Toxicology Research, Lucknow, India. His early research was focused on deciphering the mechanistic incites of arsenic-induced developmental toxicity, genetic alteration and carcinogenicity in a mouse stem cell-derived 3D reconstructed model of skin. Then he moved to the National Cancer Center (NCC), South Korea, as a post-doctoral fellow, where he culminated a task of developing the target-specific stable transformations in healthy and cancerous iPSCs to read across the customized changes in epigenetic profiling and genomic sequences, hence could be utilized to identify the drug resistance genes. For the past several years, he has been working on a rare genetic disease epidermolysis bullosa with a specific aim to identify suitable inhibitors to reduce cancer development in the RDEBSCC patients and to understand RDEB squamous cell carcinoma development. In acknowledgment of his outstanding research acumens, he has been awarded 'Carl Storm International Diversity Fellowship' at Gordon Research Conference (GRC), Italy (2013), and'Rambhau Kulkerny Best Scientist Award' at Indian Association of Cancer Research (2010). He has come up with a good number of research papers in diversified journals of high impact, to name a few are- Nature's Scientific Reports, Experimental and Molecular Medicine, PLOS-ONE, Mutagenesis, Rheumatology, Cell Biology International, Histology, and Histopathology, etc.

AB Pant 教授是一位經驗豐富的毒理學家，擁有超過三十年的活躍研究生涯。目前擔任 CSIR-印度毒理研究所（Indian Institute of Toxicology Research, Lucknow）的「高級首席科學家」，同時也是由印度國會法案設立的國家重要機構——科學與創新研究學院（Academy of Scientific & Innovative Research）的「教授」。在科學界，Pant 教授因其在人類幹細胞和誘導多能幹細胞（iPSCs）在發展性神經毒性中的應用研究而聞名，並建立了多個 in vitro 模型系統，作為生物醫學研究中實驗動物的替代方案。他還在國內創立了一個新的學科「In-Vitro 毒理學」。他致力於向研究生、博士生、研究人員和大學教師推廣當代科學。他是印度政府的主要良好實驗室規範（GLP）檢查員，並擔任多個監管機構的專家，如 BIS、CDSCO、NABL、FSSAI、NGCMA、ICMR、DST、藥物監測等。他獲得了多項獎項和榮譽，包括 2010 年的 Vigyan Ratna 獎（CST UP）、2007 年的 Shakuntala Amir Chand 獎（ICMR）、2012 年的國家生物科學獎（DBT）、2017 年的 Prof. KT Shetty 紀念演講獎（印度神經科學學院）、2018 年的毒理學促進獎（印度阿拉哈巴德科學院）、STOX/ASAW 金獎（STOX, India）等。他被選為美國毒理學科學院、印度毒理學會、印度神經科學學院、印度動物福利科學院、印度環境生物學院等的院士。鑑於在毒理學方面的卓越信譽，Pant 教授被列入「歐洲和英國毒理學家名冊」，並獲得了印度德拉敦 HNB 醫學教育大學授予的榮譽科學博士（DSc h. c.）學位。他目前擔任多個國家和國際委員會/董事會的主席和成員，並在多本知名期刊的編輯委員會中任職。

Ashish Dwivedi 博士畢業於印度盧克瑙的 CSIR-印度毒理研究所，專攻光生物學和光毒理學。此後，他在以色列科技學院、美國科羅拉多大學和印度瓦拉納西的班納拉斯印度大學擔任博士後研究員，進一步豐富了自己在該領域的研究。基於其卓越的研究經驗，他有機會回到母校 CSIR-IITR，現擔任系統毒理學與健康風險評估小組的科學家。在十年的研究生涯中，Dwivedi 博士已成為光毒性/光安全領域的先驅之一，特別是針對治療劑、納米化植物化學物質和環境污染物的光安全性。除了實驗室工作外，他還致力於向研究生、博士生、研究人員和大學教師推廣當代科學。Dwivedi 博士的研究成果在高聲望的期刊上發表了大量可量化的研究論文。他還為 Springer Nature 編輯了三本有關光保護、皮膚老化和神經保護的書籍。他是多個科學學會的成員，包括美國毒理學會、美國光生物學會、印度光生物學會、印度毒理學會等。

Ratan Singh Ray 教授是 CSIR-印度毒理研究所光生物學部的首席科學家及部門負責人。他是國內光生物學/光毒理學新學科的創始人之一。在光生物學領域擁有超過三十年的活躍研究生涯，使他成為印度標準局在化妝品和個人護理產品標準制定/修訂中的資源人員。他的研究小組負責創建了在緯度 26.8467° N 和經度 80.9462° E 的地球表面上，超過二十年來的 UV-A、UV-B 和 UV-C 輻射的完整光譜。這樣的專注和持續努力創建的數據庫為從事該研究領域的科學界、化妝品和個人護理產品的生產及研發行業以及監管機構創造了巨大的財富。他已指導超過十名博士生、數名博士後研究員和研究生。他還向多個科學學會和政府機構提供智力支持和專業知識，如印度標準局、美國光生物學會、印度光生物學會、印度毒理學會等。他的研究在科學文獻中被高度引用，Google Scholar 的得分超過 2000，H 指數為 28。他目前正在協調來自國內不同國家資助機構的多個研究資助。

Anurag Tripathi 博士目前在 CSIR-印度毒理研究所擔任首席科學家。他在班納拉斯印度大學的生物技術學院獲得了免疫調節劑和生長激素對巨噬細胞的免疫調節效應的博士學位。他的研究有助於深入了解常見食品添加劑、藥物和化妝品成分的免疫調節和免疫抑制效應。他還研究了真菌毒素的腫瘤生成潛力及其導致皮膚癌的分子機制。Tripathi 博士擁有超過十六年的研究經驗，並在《免疫學》、《分子免疫學》、《醫學的分子方面》、《毒理學快報》、《ACS Nano》、《毒理學與應用藥理學》等國際同行評審期刊上發表了 50 篇文章。他的出版物被廣泛引用，H 指數為 25。他是印度納米科學學會的終身會員，並在多本知名國際期刊上擔任編輯委員會成員，如《免疫學與血清生物學期刊》、《SM 納米技術與納米醫學期刊》、《毒理學與法醫案例期刊》和《奧斯汀免疫學期刊》。

Atul Kumar Upadhyay 博士於 2015 年在班加羅爾的國家生物科學中心（NCBS）和孟買的塔塔基礎研究所（TIFR）獲得生命科學博士學位。他的主要研究領域圍繞深入的植物基因組分析和計算模擬，以開發數據庫管理系統和生物信息學工具。他於 2016 年在印度賈蘭達爾的美麗專業大學擔任助理教授，開始了他的教學生涯。目前，他在印度旁遮普州的 Thapar 工程與技術學院（TIET）生物技術系擔任助理教授。他的專業領域包括比較基因組學和生物信息學、計算生物學、生物分子的分子建模和藥物設計。基於他的研究，他在國內外高聲望的期刊上發表了大量研究論文。除了研究出版物外，他還為 Springer Nature 編輯了一本名為《農業生物信息學：高通量方法》的書籍。他在其專業領域的多個書籍章節中擔任作者或合著者。目前，他還在幾本優秀的研究期刊中擔任編輯成員。

Shiv Poojan 博士目前在美國賓夕法尼亞州費城的西德尼·基梅爾癌症中心（Sidney Kimmel Cancer Center, Thomas Jefferson University）擔任科學家。他是 CSIR-印度毒理研究所的研究生。他早期的研究專注於解碼砷引起的發展性毒性、基因變化和小鼠幹細胞衍生的 3D 重建皮膚模型中的致癌機制。隨後，他作為博士後研究員轉到韓國國立癌症中心（NCC），在那裡他完成了開發針對健康和癌變 iPSCs 的特定穩定轉化的任務，以讀取表觀遺傳剖面和基因組序列的定制變化，從而可用於識別藥物抗性基因。在過去幾年中，他一直在研究一種罕見的遺傳疾病——表皮水疱症，特別旨在識別合適的抑制劑以減少 RDEBSCC 患者的癌症發展，並了解 RDEB 鱗狀細胞癌的發展。因其卓越的研究才能，他獲得了 2013 年在意大利戈登研究會議（Gordon Research Conference, GRC）頒發的「Carl Storm 國際多樣性獎學金」和 2010 年印度癌症研究協會頒發的「Rambhau Kulkerny 最佳科學家獎」。他在多本高影響力的多樣化期刊上發表了大量研究論文，包括《自然科學報告》、《實驗與分子醫學》、《PLOS-ONE》、《突變學》、《風濕病學》、《細胞生物學國際期刊》、《組織學》和《組織病理學》等。