Tumor Ecosystem: An Ecological View of Cancer Growth and Survival
Song, Erwei
- 出版商: Springer
- 出版日期: 2024-07-21
- 售價: $6,030
- 貴賓價: 9.5 折 $5,729
- 語言: 英文
- 頁數: 701
- 裝訂: Quality Paper - also called trade paper
- ISBN: 9819911850
- ISBN-13: 9789819911851
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商品描述
This book intends to report new concept of onco-spheres in cancer ecosystem. Onco-spheres are defined as where cancer cells (living organisms) dynamically interact with nontumor cellular (other living organisms) and noncellular components (non-living environmental factors) in the 'host' internal environment (habitat) to construct a self-sustainable cancer ecosystem, which can be scoped at three different levels: primary/regional, distal and systemic onco-spheres.
Cancer cells should be conceived as 'living organisms', interacting with cellular or noncellular components in the host internal environment, not only with the local tumor microenvironment (TME) but also constantly communicating with a distant organ niche as well interacting with the host's nervous, endocrine and immune systems, to construct a self-sustainable 'biosphere', as we termed the tumor ecosystem. By looking at theinteraction of cancer and host as a unique ecosystem, we will use ecology principles to further delineate the features of the dynamics of the tumor ecosystem.
As the pioneer in proposing this concept, we feel that this full-scale overview of the tumor ecosystem is able to inform the readers about this concept, and to pave the way for designing novel therapeutic strategies on actionable targets within tumor ecosystem. The book is likely to be of interest to immunologist, biologist, medical students, researchers and general public who wish to learn more on this new concept of tumor ecosystem, and how this could be applied in many fields of research.
商品描述(中文翻譯)
本書旨在報告癌症生態系統中新概念的 onco-spheres。Onco-spheres 被定義為癌細胞（活生物）與非腫瘤細胞（其他活生物）及非細胞成分（非生物環境因素）在「宿主」內部環境（棲息地）中動態互動的地方，以構建一個自我可持續的癌症生態系統，這可以在三個不同層面上進行範疇劃分：初級/區域性、遠端和系統性 onco-spheres。
癌細胞應被視為「活生物」，與宿主內部環境中的細胞或非細胞成分互動，不僅與局部腫瘤微環境（TME）互動，還不斷與遠端器官小環境進行交流，並與宿主的神經、內分泌和免疫系統互動，以構建一個自我可持續的「生物圈」，我們稱之為 腫瘤生態系統。通過將癌症與宿主的互動視為一個獨特的生態系統，我們將利用生態學原則進一步闡明腫瘤生態系統動態的特徵。
作為提出這一概念的先驅，我們認為這一全面的腫瘤生態系統概述能夠讓讀者了解這一概念，並為設計針對腫瘤生態系統內可行目標的新療法策略鋪平道路。本書可能會引起免疫學家、生物學家、醫學生、研究人員以及希望了解這一新概念及其在多個研究領域應用的公眾的興趣。
作者簡介
Erwei Song is Professor of Breast Surgery at Sun Yat-sen University (SYSU), Member of Chinese Academy of Sciences, "Cheung Kong Scholar" Chair Professor, CMB (China Medical Board) Distinguished Professor and Fellow of the Royal Society of Biology (UK). Currently, he serves as President of Sun Yat-sen Memorial Hospital, SYSU. Erwei obtained his M.D. and Ph.D. at Zhongshan Medical School, and was trained as a surgeon at Sun Yat-sen Memorial Hospital, SYSU. He received postdoc training at Harvard Medical School in 2002 and became an instructor at the CBR Institute of Biomedical Research at Harvard in 2004. His early publication "RNA interference targeting Fas protects mice from fulminant hepatitis" in Nature Medicine was the first to report that siRNA could be used therapeutically in whole animal disease model. This finding was selected as one of the "Top Ten breakthroughs of the year 2003" by Science. In 2005, he returned to China and set up his own lab at Sun Yat-sen University.
As a clinician scientist, he is keen to address scientific questions derived from clinical practice. He is among the first doctors in China to perform breast-conserving surgery for breast cancer patients, which preserves the microenvironment tissues for activation of anti-tumor immunity. His study has proposed and solidified "the Theory of Tumor Ecosystem", which sheds new lights on immunotherapy. He has identified various new subtypes of cancer-associated immune cells and mesenchymal cells, new receptors of various crucial cytokines, and a new archetype of long non-coding RNAs that function as signaling molecules to regulate intracellular or intercellular signal transduction. These findings provide new therapeutic strategies for targeting tumor microenvironment as well as immunotherapies for solid tumors. By comparing patient samples before and after treatments, he has also demonstrated the critical role of miRNAs in regulating the biology of cancer stem cells (CSC).
Prof. Song has published 156 SCI research articles, including Nature (1 paper), Cell (3 papers), Cancer Cell (3 papers), Nature Immunology (2 papers), Nature Cell Biology, Nature Cancer, Science Translational Medicine, Nature Communications (4 papers), etc. Owing to his academic achievements, Prof. Song was invited to contribute a review article on tumor microenvironment for Nature Reviews Drug Discovery and chair an international Cell Symposium for Cell Press on "Functional RNAs". As a surgeon, Dr. Song compiled the first Chinese Experts Guidelines for Breast-conserving Surgeries of Early Breast Cancer. By far, his research papers have been cited for 12012 times. As the corresponding author, he has published 73 research articles, with one of them being cited for 1458 times and sixteen of them being cited for more than 100 times.
Prof. Song serves as the associate editor for BMC Cancer, Cancer Science, Science China-Life Sciences, Journal of Bio-X Research, and the reviewing editor for Journal of Biological Chemistry, as well as the editorial board member of Signal Transduction and Targeted Therapy. His research work was selected as Top Ten Scientific and Technological Breakthrough by the Ministry of Education in China in 2008 and 2018, respectively. He has won numerous awards, including the "Ho Leung Ho Lee Foundation Award" and the "National Natural Science Award" by the State Council of China, etc. In 2020, he was granted with the National Innovation Award by the Ministry of Science and Technology, the JCA International Award by the Japanese Cancer Association and the TWAS Award in Medical Sciences for his contribution to proposing and reinforcing the theory of tumor ecosystem.
作者簡介(中文翻譯)
鄂維松教授是中山大學乳腺外科的教授，中國科學院院士，長江學者特聘教授，中國醫學委員會（CMB）傑出教授，以及英國生物學皇家學會的院士。目前，他擔任中山紀念醫院的院長。鄂維松在中山醫學院獲得醫學博士（M.D.）和哲學博士（Ph.D.）學位，並在中山紀念醫院接受外科醫生的訓練。他於2002年在哈佛醫學院接受博士後訓練，並於2004年成為哈佛CBR生物醫學研究所的講師。他早期的發表《RNA干擾針對Fas可保護小鼠免受急性肝炎影響》發表於《Nature Medicine》，是首個報告siRNA可用於整體動物疾病模型的治療性研究。這一發現被《Science》選為2003年「十大突破」之一。2005年，他回到中國並在中山大學建立了自己的實驗室。
作為一名臨床科學家，他熱衷於解決源自臨床實踐的科學問題。他是中國首批為乳腺癌患者進行乳房保留手術的醫生之一，該手術保留了微環境組織以激活抗腫瘤免疫。他的研究提出並鞏固了「腫瘤生態系統理論」，為免疫療法提供了新的視角。他已識別出多種新的癌症相關免疫細胞和間質細胞亞型、新的關鍵細胞因子受體，以及一種新的長非編碼RNA原型，這些RNA作為信號分子調節細胞內或細胞間的信號傳導。這些發現為針對腫瘤微環境的治療策略以及實體腫瘤的免疫療法提供了新的思路。通過比較患者在治療前後的樣本，他還展示了miRNA在調節癌症幹細胞（CSC）生物學中的關鍵作用。
鄂教授已發表156篇SCI研究文章，包括《Nature》（1篇）、《Cell》（3篇）、《Cancer Cell》（3篇）、《Nature Immunology》（2篇）、《Nature Cell Biology》、《Nature Cancer》、《Science Translational Medicine》、《Nature Communications》（4篇）等。由於其學術成就，鄂教授受邀為《Nature Reviews Drug Discovery》撰寫有關腫瘤微環境的綜述文章，並主持Cell Press的國際Cell研討會，主題為「功能性RNA」。作為外科醫生，鄂博士編寫了首部中國專家早期乳腺癌乳房保留手術指南。迄今為止，他的研究論文已被引用12012次。作為通訊作者，他已發表73篇研究文章，其中一篇被引用1458次，十六篇被引用超過100次。
鄂教授擔任《BMC Cancer》、《Cancer Science》、《Science China-Life Sciences》、《Journal of Bio-X Research》的副編輯，以及《Journal of Biological Chemistry》的審稿編輯，並且是《Signal Transduction and Targeted Therapy》的編輯委員會成員。他的研究工作在2008年和2018年分別被中國教育部評選為十大科技突破。他獲得了多項獎項，包括「何梁何利基金獎」和中國國務院頒發的「國家自然科學獎」等。2020年，他因為在提出和強化腫瘤生態系統理論方面的貢獻，獲得了科技部的國家創新獎、日本癌症協會的JCA國際獎以及TWAS醫學科學獎。
