Biomarkers in Cancer Therapy: Liquid Biopsy Comes of Age
暫譯: 癌症療法中的生物標記:液體活檢的成熟之路

Shimada, Hideaki

  • 出版商: Springer
  • 出版日期: 2019-07-05
  • 售價: $5,230
  • 貴賓價: 9.5$4,969
  • 語言: 英文
  • 頁數: 157
  • 裝訂: Hardcover - also called cloth, retail trade, or trade
  • ISBN: 9811372942
  • ISBN-13: 9789811372940
  • 海外代購書籍(需單獨結帳)

商品描述

This book sheds new light on research into liquid biopsy biomarkers for cancer screening. The chapters in the first half address exosomes, circulating cell-free DNA and autoantibodies, and main solid cancers, along with companion biomarkers - all of which serve as the basis for exploring key research questions for future clinical trials in the book's second half.

The study of biomarkers has evolved rapidly thanks to advances in precision medicine. While conventional cancer biomarker research is focused on proteomics or gene analysis of resected tissue, diagnostic markers have since become significant in terms of gauging the effectiveness of molecularly targeted drugs or the likelihood of a favorable prognosis. In addition, conventional treatment strategy, which draws on archives of resected tissue samples, is now gradually being replaced by monitoring with the use of liquid biopsy, which is poised to become the new mainstream in molecular targeting therapy.

The contributing authors discuss in detail biomarkers, molecular targets for treatment, monitoring markers to evaluate treatment responses, prognostic markers, and screening and early diagnosis. Accordingly, this excellent collection of texts will benefit not only oncologists, but also medical and biological researchers and pharmaceutical scientists involved in the latest cancer research.


商品描述(中文翻譯)

這本書為癌症篩檢的液體活檢生物標記研究提供了新的見解。前半部分的章節探討了外泌體、循環游離DNA和自體抗體,以及主要的實體癌症和伴隨生物標記,這些都是為了探索本書後半部分未來臨床試驗的關鍵研究問題而奠定基礎。

由於精準醫療的進步,生物標記的研究迅速發展。傳統的癌症生物標記研究主要集中在切除組織的蛋白質組學或基因分析上,而診斷標記在評估分子靶向藥物的有效性或預測良好預後的可能性方面變得越來越重要。此外,傳統的治療策略依賴於切除組織樣本的檔案,現在逐漸被液體活檢的監測所取代,液體活檢有望成為分子靶向治療的新主流。

貢獻的作者詳細討論了生物標記、治療的分子靶點、用於評估治療反應的監測標記、預後標記,以及篩檢和早期診斷。因此,這本優秀的文本集將不僅有利於腫瘤科醫生,還將惠及參與最新癌症研究的醫學和生物研究人員以及藥物科學家。

作者簡介

Dr. Hideaki Shimada is a Professor of Surgery at Toho University Hospital. He received his MD and PhD from Chiba University and had the privilege of studying cancer biochemistry under Professor Masamichi Tatibana from 1987 to 1990. In the course of his career, he has served on numerous committees for national and international societies regarding cancer treatment, surgery and biomarkers. His current area of interest is in cancer biomarkers, specifically in gastroenterological cancer. The author of the recent Japanese Molecular Tumor Marker Guideline, and of the Japanese Gastric Cancer Treatment Guideline, Dr. Shimada also serves as an editor for various international journals, e.g. Cancer Science, Ann Gastroenterological Surgery, Esophagus, Gastric Cancer, Ann Thoracic Cardiovascular Surgery, Digestive Surgery, and Surgery Today. In 2016 he received the JSGS (Japanese Society of Gastroenterological Surgery) Scientist of the Year Award.

作者簡介(中文翻譯)

島田英明博士是東邦大學醫院的外科教授。他在千葉大學獲得醫學博士(MD)和哲學博士(PhD)學位,並有幸在1987年至1990年間跟隨田邊正道教授學習癌症生物化學。在他的職業生涯中,他曾參與多個國內外社會的委員會,專注於癌症治療、外科手術和生物標記物。目前,他的研究興趣集中在癌症生物標記物,特別是胃腸道癌症。作為最近的《日本分子腫瘤標記物指導方針》和《日本胃癌治療指導方針》的作者,島田博士還擔任多本國際期刊的編輯,例如《癌症科學》、《胃腸外科年鑑》、《食道》、《胃癌》、《胸腔心血管外科年鑑》、《消化外科》和《今日外科》。在2016年,他獲得了日本胃腸外科學會(JSGS)年度科學家獎。