Transcription Factors in Blood Cell Development
Borggrefe, Tilman, Giaimo, Benedetto Daniele
- 出版商: Springer
- 出版日期: 2024-07-18
- 售價: $8,370
- 貴賓價: 9.5 折 $7,952
- 語言: 英文
- 頁數: 524
- 裝訂: Hardcover - also called cloth, retail trade, or trade
- ISBN: 303162730X
- ISBN-13: 9783031627309
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商品描述
This book describes transcription factors in the context of hematopoietic development and reveal mechanistic insights how they orchestrate specific gene expression patterns. Several examples from lymphoid and myeloid lineages are given as well as particular examples of leukemia fusion proteins that contain a part of a transcription factor. In the given chapters covering each one particular example, the function of transcription factors is characterized in normal as well as leukemic contexts.
New technologies such as ChIP-Seq or RNA-Seq, that make use of genome-wide sequencing, have shown that such master regulators of blood cell development often work in combinatorial fashion and, when dysregulated, results in leukemogenesis.
This book is not only intended for experts but it should also be a useful resource for younger scientists or scientists from other disciplines, who may use this book as a stimulating starting point for further discoveries and/ or translational endeavors.
商品描述(中文翻譯)
這本書描述了轉錄因子在造血發育中的角色，並揭示了它們如何組織特定基因表達模式的機制洞察。書中提供了淋巴細胞和骨髓細胞系的幾個例子，以及包含轉錄因子部分的白血病融合蛋白的特定例子。在每個特定例子的章節中，對轉錄因子在正常和白血病背景下的功能進行了特徵化描述。
新技術，如ChIP-Seq或RNA-Seq，利用全基因組测序的方法，顯示了這些血液細胞發育的主要調控因子通常以組合方式工作，當其失調時會導致白血病發生。
這本書不僅適用於專家，也可作為年輕科學家或其他學科的科學家的有用資源，他們可以將本書作為刺激性的起點，進一步進行發現和/或轉譯研究。
作者簡介
Dr. Tilman Borggrefe studied biochemistry at the Imperial College London before obtaining his PhD at the Basel Institute for Immunology (Switzerland). He performed postdoctoral studies at Stanford University (R. Kornberg laboratory, USA) and was Max-Planck independent group leader in Freiburg im Breisgau (Germany). Since 2012 he is professor for biochemistry at the University of Giessen (Germany).
Dr. Benedetto Daniele Giaimo studied biology at the University of Palermo (Italy) before obtaining his Ph.D at the Max Planck Institute of Freiburg im Breisgau (Germany). Since 2012, Dr. Giaimo is a scientist at the University of Giessen (Germany).
作者簡介(中文翻譯)
Dr. Tilman Borggrefe在倫敦帝國學院學習生物化學，並在巴塞爾免疫學研究所（瑞士）獲得博士學位。他在斯坦福大學（美國）進行博士後研究，並在德國弗賴堡的馬克斯普朗克研究所擔任獨立研究小組領導。自2012年起，他擔任德國吉森大學的生物化學教授。
Dr. Benedetto Daniele Giaimo在意大利巴勒莫大學學習生物學，並在德國弗賴堡的馬克斯普朗克研究所獲得博士學位。自2012年起，Dr. Giaimo在德國吉森大學擔任科學家。
