Optical Polarimetric Modalities for Biomedical Research
Mazumder, Nirmal, Kistenev, Yury V., Borisova, Ekaterina
- 出版商: Springer
- 出版日期: 2024-07-27
- 售價: $5,040
- 貴賓價: 9.5 折 $4,788
- 語言: 英文
- 頁數: 452
- 裝訂: Quality Paper - also called trade paper
- ISBN: 3031318544
- ISBN-13: 9783031318542
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商品描述
This book focuses on polarization microscopy, a powerful optical tool used to study anisotropic properties in biomolecules, and its enormous potential to improve diagnostic tools for various biomedical research. The interaction of polarized light with normal and abnormal regions of tissue reveals structural information associated with its pathological condition. Diagnosis using conventional microscopy can be time-consuming, as pathologists require an hour to freeze and stain tissue slices from suspected patients. In comparison, polarization microscopy more quickly distinguishes abnormal tissue and provides better microstructural information of samples, even in the absence of staining. This book provides a basic understanding of the properties of polarized light, a description of the polarization microscope, and a mathematical formalism of Mueller matrix polarimetry. The authors discuss various advanced linear and nonlinear optical techniques such as optical coherence tomography (OCT), reflectance and transmission spectroscopy, fluorescence, multiphoton excitation, second harmonic generation, Raman microscopy, and more. They explore the exciting potential of integrating polarimetry with these techniques for possible applications in different areas of biomedical research, as well as the associated challenges. Including the most recent developments on the topic, this book serves as a modern guide to polarization microscopy and advancements in its use in biomedical research.
商品描述(中文翻譯)
本書專注於偏振顯微鏡，這是一種強大的光學工具，用於研究生物分子的各向異性特性，以及其在改善各種生物醫學研究診斷工具方面的巨大潛力。偏振光與正常和異常組織區域的相互作用揭示了與其病理狀況相關的結構信息。使用傳統顯微鏡進行診斷可能耗時，因為病理學家需要一小時來冷凍和染色來自可疑患者的組織切片。相比之下，偏振顯微鏡能更快地區分異常組織，並提供樣本的更好微觀結構信息，即使在沒有染色的情況下。本書提供了對偏振光特性的基本理解，描述了偏振顯微鏡，以及穆勒矩陣偏振測量的數學形式。作者討論了各種先進的線性和非線性光學技術，如光學相干斷層掃描（OCT）、反射和透射光譜、螢光、多光子激發、二次諧波生成、拉曼顯微鏡等。他們探討了將偏振測量與這些技術整合的令人興奮的潛力，以便在不同的生物醫學研究領域進行可能的應用，以及相關的挑戰。本書包括該主題的最新發展，作為偏振顯微鏡及其在生物醫學研究中應用進展的現代指南。
作者簡介
Dr. Nirmal Mazumder is an Assistant Professor at the Department of Biophysics, Manipal School of Life Sciences, Manipal Academy of Higher Education (MAHE), Manipal, India. He obtained his Ph.D. in 2013 from National Yang Ming Chiao Tung University, Taipei, Taiwan. From 2013 to 2016, he worked as a postdoctoral fellow at the University of Virginia, the USA, and the Italian Institute of Technology, Genoa, Italy. He has been developing nonlinear optical microscopes, including two photon fluorescence, second harmonic generation, coherent anti-Stokes Raman scattering for biomedical applications. His research interests include development of microscopy-spectroscopy techniques, biomedical devices, biophotonics, smart materials, microfluidics and its biomedical applications. He has published more than 70 research articles in the peer-reviewed international journals, 7 books, 30 book chapters, and several poster/oral/invited presentations in National and International conferences. He is working on several national and bilateral research projects funded by Government of India as Principal Investigator. He is also working as the reviewer/guest editor/associate editors in several prestigious journals. He is the member of several national and international scientific societies and organizations including, the Optical Society (OSA) (Senior member), SPIE--the International Society for Optical Engineering (Senior member), Society of Biological Chemists (I) (Life Member), Environmental Mutagen Society of India (Life Member), Asian Polymer Association (Life Member).
Prof. Yury V. Kistenev is a professor in the Department of Physics at Tomsk State University (TSU) and serves as the head for the Laboratory of Biophotonics. He received his Ph.D. in Optics in 1987 and his Ph.D. in Physics and Mathematics in 1997. Prof. Kistenev is the author of more than 150 journal papers and has written two book chapters. His currentresearch interests include laser molecular imaging, laser spectroscopy, and machine learning.
Dr. Ekaterina G. Borisova serves as the head of the Biophotonics Laboratory at the Institute of Electronics, Bulgarian Academy of Sciences (IE-BAS). She received her M.S. degrees in Medical Physics and Laser Physics from Sofia University in 2000 and her Ph.D. in Physics from IE-BAS in 2005. Her recent investigations cover the field of biophotonics, including molecular spectroscopy of biological samples, photodiagnosis and photodynamic therapy, optical techniques such as fluorescence, diffuse reflectance, Raman spectroscopy, absorption and transmission spectroscopy, and the microscopy of biological tissues for diagnostics of socially significant diseases. She also studies the polarimetry of histological samples for prospective and retrospective analysis of tumors, as well for the development of novel photonic sensors for biomedical applications. Dr. Borisova is a co-authorof more than 150 articles, 8 book chapters, and 5 patents in the field of biophotonics and it applications. She also works as a reviewer and guest editor for several prestigious journals in the field of optics and biomedical photonics. She is a member of more than 50 international organizations and a senior member of SPIE and OSA. Dr. Borisova received the Grand Prix "Pythagoras" award in 2012 from the Bulgarian Ministry of Education and Science for her research results in the field of photonics and development of noninvasive methods for early diagnosis of cancer. She also received the national L'Oréal-UNESCO award "For Women in Science" in 2014 for her investigations in the field of polarization-sensitive fluorescence detection of cancer.
Dr. Shama Prasada K. is a cell and molecular biologist working in the area of cancer epigenetics. Currently, Dr. Shama is an associate professor at the Manipal Academy of Higher Education, School of Life Sciences and is the head of the Department of Cell and Molecular Biology. He obtained his M.S. in Biosciences from Mangalore University and his Ph.D. from Manipal University. Dr. Shama's research expertise lies in identifying the epigenetic changes responsible for carcinogenesis, translating clinically relevant biomarkers for diagnostic, prognostic, and therapeutic use, and delineating key cell and molecular events responsible for carcinogenesis. He uses cell lines, the nude mice model, and genome editing technologies to understand the regulation and biological function of DNA methylation regulated genes and miRNAs in the pathophysiology of cervical cancer. Dr. Shama served as an editorial manager for the Public Health Genomics Journal published by Karger Press. He currently serves as an associate editor for Frontiers in Genetics, Frontiers in Oncology, and BMC Medical Genomics as well as an academic editor for PlosOne. Dr. Shama is a member of the Indian Society of Mitochondrial Research in Medicine (SMRM-India) and the Indian Society of Biological Chemists. His research has generated 84 publications, 3 book chapters, 2 general articles, 7 conference proceedings, 2 patents, and 52 invited presentations at international conferences.
作者簡介(中文翻譯)
Dr. Nirmal Mazumder 是印度 Manipal 高等教育學院 (MAHE) Manipal 生命科學學院生物物理學系的助理教授。他於 2013 年在台灣國立陽明交通大學獲得博士學位。從 2013 年到 2016 年，他在美國維吉尼亞大學和意大利熱那亞的意大利科技研究所擔任博士後研究員。他一直在開發非線性光學顯微鏡，包括兩光子螢光、二次諧波產生、相干反斯托克斯拉曼散射等生物醫學應用技術。他的研究興趣包括顯微鏡-光譜技術的發展、生物醫學設備、生物光子學、智能材料、微流體技術及其生物醫學應用。他在同行評審的國際期刊上發表了超過 70 篇研究文章，出版了 7 本書、30 篇書章，並在國內外會議上進行了多次海報/口頭/受邀報告。他作為主要研究者參與了多個由印度政府資助的國家和雙邊研究項目。他還在多本知名期刊擔任審稿人/客座編輯/副編輯。他是多個國內外科學學會和組織的成員，包括光學學會 (OSA)（資深會員）、SPIE—國際光學工程學會（資深會員）、生物化學學會 (I)（終身會員）、印度環境突變學會（終身會員）、亞洲聚合物協會（終身會員）。
Prof. Yury V. Kistenev 是俄羅斯湯斯克國立大學 (TSU) 物理系的教授，並擔任生物光子學實驗室的負責人。他於 1987 年獲得光學博士學位，1997 年獲得物理與數學博士學位。Kistenev 教授是超過 150 篇期刊論文的作者，並撰寫了兩篇書章。他目前的研究興趣包括激光分子成像、激光光譜學和機器學習。
Dr. Ekaterina G. Borisova 擔任保加利亞科學院電子學研究所 (IE-BAS) 生物光子學實驗室的負責人。她於 2000 年在索非亞大學獲得醫學物理和激光物理的碩士學位，並於 2005 年在 IE-BAS 獲得物理博士學位。她最近的研究涵蓋生物光子學領域，包括生物樣本的分子光譜學、光診斷和光動力療法、光學技術如螢光、漫反射、拉曼光譜學、吸收和傳輸光譜學，以及生物組織顯微鏡檢查以診斷社會重要疾病。她還研究組織學樣本的偏振測量，以進行腫瘤的前瞻性和回顧性分析，以及開發新型光子傳感器以應用於生物醫學。Borisova 博士是超過 150 篇文章、8 篇書章和 5 項生物光子學及其應用領域專利的共同作者。她還擔任多本光學和生物醫學光子學領域知名期刊的審稿人和客座編輯。她是超過 50 個國際組織的成員，並且是 SPIE 和 OSA 的資深會員。Borisova 博士於 2012 年獲得保加利亞教育與科學部頒發的「畢達哥拉斯」大獎，以表彰她在光子學領域的研究成果及開發非侵入性癌症早期診斷方法。她還於 2014 年因在癌症偏振敏感螢光檢測領域的研究而獲得國家 L'Oréal-UNESCO「女性科學家」獎。
Dr. Shama Prasada K. 是一位細胞與分子生物學家，專注於癌症表觀遺傳學。目前，Shama 博士是 Manipal 高等教育學院生命科學學院的副教授，並擔任細胞與分子生物學系的負責人。他獲得了...
