Potency Assays for Advanced Stem Cell Therapy Medicinal Products

Jorge S. Burns received his degree in Cellular Pathology at the University of Bristol and PhD at the University of Wales College of Medicine in 1992, authoring the first UK manuscript to describe the use of retroviral vectors in epithelial cells. At the Ludwig Institute for Cancer Research, University College London Branch, a postdoctoral fellowship in Breast Cancer research provided technology insights leading to an appointment at renowned proteome research facilities at the University of Southern Denmark in Odense. Subsequent industrial experience was obtained with management of a cell culture facility supporting mass spectrometry for immune therapy target discovery at MDS Proteomics A/S. Joining the academic research team led by Prof. Moustapha Kassem at Odense University Hospital brought focus on human bone marrow derived stromal cells and their osteogenic differentiation potential, plus participation in the Innovation Consortium 3-D scaffolds. Preclinical stem cell characterisation studies progressed to translational regenerative medicine at the University of Modena in Italy, upon joining the EU Framework 7 Reborne consortium, whereby bone therapy clinical trials required exploration of novel osteogenic potency assays. To pursue development of potency assay biosensors, Prof. Burns obtained an award for project number 154/25.11.2016, P_37_221/2015, "A novel GRaphene Biosensor Testing Osteogenic Potency; capturing best stem cell performance for regenerative medicine" (GRABTOP), from the Ministry of Research and Innovation in Romania, Operational Program Competitiveness Axis 1 Section E, co-financed from European Regional Development Fund "Investments for your future". The multidisciplinary laboratory inaugurated at the Faculty of Medical Engineering, University Politehnica of Bucharest, tested the applicability of the nanomaterial graphene and its diverse functionalised forms. Current research interests revolve around improved methods of in vivo mimicryat the Department of Environmental and Prevention Sciences at the University of Ferrara.

Jorge S. Burns於1992年在布里斯托大學獲得細胞病理學學位，並在威爾士醫學院獲得博士學位，撰寫了第一篇描述在上皮細胞中使用逆轉錄病毒載體的英國手稿。在倫敦大學學院的路德維希癌症研究所，進行乳腺癌研究的博士後研究獲得了技術見解，隨後被任命至位於丹麥奧登塞的南丹麥大學著名的蛋白質組研究設施。隨後，他在MDS Proteomics A/S管理一個支持質譜分析的細胞培養設施，專注於免疫療法靶點的發現。加入由Moustapha Kassem教授領導的奧登塞大學醫院學術研究團隊後，專注於人類骨髓來源的基質細胞及其成骨分化潛力，並參與創新聯盟3-D支架的研究。前臨床幹細胞特徵化研究進展至意大利摩德納大學的轉化再生醫學，並加入了歐盟第七框架計畫Reborne聯盟，該計畫要求探索新型成骨效能測試以支持骨療法臨床試驗。為了開發效能測試生物感測器，Burns教授獲得了羅馬尼亞研究與創新部的獎項，項目編號154/25.11.2016，P_37_221/2015，題為「一種新型石墨烯生物感測器測試成骨效能；捕捉再生醫學最佳幹細胞表現」（GRABTOP），該項目由歐洲區域發展基金「投資你的未來」共同資助，屬於運營計畫競爭力軸線1第E部分。在布加勒斯特理工大學醫學工程學院成立的多學科實驗室，測試了納米材料石墨烯及其多樣化功能化形式的適用性。目前的研究興趣圍繞在費拉拉大學環境與預防科學系改進體內模擬方法。