Covid-19 Metabolomics and Diagnosis: Volume 2

Frank N. Crespilho is Professor of Physical-Chemistry at Chemistry Institute of University of Sao Paulo, São Carlos since 2012. He was Associate Professor of Chemistry at Federal University (UFABC), Brazil (2009-2012), Visiting Associate in Chemistry at California Institute of Technology, Caltech (EUA), and Visiting Professor at Max-Planck-Institute for Solid State Research, Stuttgart, Germany (2016). He was Visiting Professor at Harvard University (2018-2019) and since 2019 he is Fellow of the J. A. P. School of Engineering and Applied Sciences, Harvard University at the lab of Prof. Michael Aziz. He is the Coordinator of COVID-19 Network in metabolomics and diagnostics chemistry at the University of São Paulo. He was one of the inventors of the "Popular Fast Test of COVID-19", costing less than a dollar, for mass testing in developing countries. His research interests include fundamental and applied bioelectrochemistry with a distinctive focus on the chemistry of energy, life and health. His work combines physical chemical methods and instrumentation development timely application to biological fuel cells and bioinspired batteries, biosensors technology and electron transfer reactions in biological system. His recent work focuses on in situ and operando spectroscopic-electrochemistry elucidation of the electron transfer mechanism involving redox enzyme, proteins, DNA, and drug delivery in single cells. He has made contributions on the field of protein immobilization processes on solid surfaces, single cells micro-FTIR analysis, bio-electrocatalysis and coupling analytical tools to resolve electron transfer mechanism in proteins. Dr. Crespilho developed a technique named Electrochemical Coupled Vibrational Spectromicroscopy (EVSM), which consist in a multiplex infrared spectroscopy imaging system for monitoring spatially resolved redox chemistry in bioelectrodes, bioinorganic molecules, biological films and single cells.

Frank N. Crespilho 自2012年以來擔任聖保羅大學化學研究所的物理化學教授。他曾於2009年至2012年擔任巴西聯邦大學（UFABC）的化學副教授，並在加州理工學院（Caltech）擔任化學訪問副教授，以及在德國斯圖加特的馬克斯·普朗克固態研究所擔任訪問教授（2016年）。他於2018年至2019年擔任哈佛大學的訪問教授，自2019年起成為哈佛大學J. A. P. 工程與應用科學學院的研究員，並在Michael Aziz教授的實驗室工作。他是聖保羅大學COVID-19代謝組學與診斷化學網絡的協調員。他是「COVID-19普及快速測試」的發明者之一，該測試成本低於一美元，旨在為發展中國家提供大規模檢測。他的研究興趣包括基礎和應用生物電化學，特別關注能源、生命和健康的化學。他的工作結合了物理化學方法和儀器開發，及時應用於生物燃料電池和生物啟發電池、biosensor技術以及生物系統中的電子轉移反應。他最近的研究專注於原位和操作中的光譜電化學，闡明涉及氧化還原酶、蛋白質、DNA和單細胞藥物傳遞的電子轉移機制。他在固體表面蛋白質固定化過程、單細胞微型傅立葉變換紅外光譜分析、生物電催化以及結合分析工具以解析蛋白質中的電子轉移機制方面做出了貢獻。Crespilho博士開發了一種名為電化學耦合振動光譜顯微術（EVSM）的技術，這是一種多重紅外光譜成像系統，用於監測生物電極、生物無機分子、生物薄膜和單細胞中的空間解析氧化還原化學。