Molecular Biology of Long Non-Coding Rnas
暫譯: 長非編碼RNA的分子生物學
Khalil, Ahmad M.
- 出版商: Springer
- 出版日期: 2019-06-24
- 售價: $6,720
- 貴賓價: 9.5 折 $6,384
- 語言: 英文
- 頁數: 187
- 裝訂: Hardcover - also called cloth, retail trade, or trade
- ISBN: 3030170853
- ISBN-13: 9783030170851
海外代購書籍(需單獨結帳)
商品描述
This second edition shows how long non-coding RNAs (lnc)RNAs have emerged as a new paradigm in epigenetic regulation of the genome. Thousands of lncRNAs have been identified and observed in a wide range of organisms. Unlike mRNA, lncRNA have no protein-coding capacity. So, while their function is not entirely clear, they may serve as key organizers of protein complexes that allow for higher order regulatory events. Advances in the field also include better characterization of human long non-coding RNAs, novel insights into their roles in human development and disease, their diverse mechanisms of action and novel technologies to study them.
商品描述(中文翻譯)
本書第二版展示了長非編碼RNA（long non-coding RNAs, lncRNAs）如何成為基因組表觀遺傳調控的新範式。已經在各種生物中識別並觀察到數千種lncRNAs。與mRNA不同，lncRNA不具備蛋白質編碼能力。因此，儘管它們的功能尚不完全清楚，但它們可能作為蛋白質複合體的關鍵組織者，促進更高階的調控事件。該領域的進展還包括對人類長非編碼RNA的更好特徵描述、對其在人體發育和疾病中的角色的新見解、其多樣的作用機制以及研究它們的新技術。
作者簡介
Ahmad Khalil earned his PhD at the University of Florida School of Medicine where he discovered key epigenetic mechanisms that regulate gene expression during mammalian meiosis. Subsequently, he joined the Scripps Research Institute as a postdoctoral fellow (2006-2008) and studied the role of long non-coding RNAs in neurological disorders. In 2008, Dr Khalil moved to Harvard Medical School and the Broad Institute where he played a key role in discovering long intergenic non-coding (linc)RNAs in human cells, and demonstrated that lincRNAs play critical roles in epigenetic regulation of gene expression. In 2010, Dr Khalil joined the faculty at CWRU and his lab continues to study the role of lincRNAs in human health and disease.
作者簡介(中文翻譯)
阿哈邁德·卡利爾（Ahmad Khalil）在佛羅里達大學醫學院獲得博士學位，期間他發現了調控哺乳動物減數分裂中基因表達的關鍵表觀遺傳機制。隨後，他於2006年至2008年間加入斯克里普斯研究所擔任博士後研究員，研究長非編碼RNA在神經疾病中的角色。2008年，卡利爾博士轉至哈佛醫學院和布羅德研究所，在那裡他在發現人類細胞中的長間隔非編碼RNA（lincRNA）方面發揮了關鍵作用，並證明了lincRNA在基因表達的表觀遺傳調控中扮演著重要角色。2010年，卡利爾博士加入凱斯西儲大學（CWRU）的教職，並且他的實驗室持續研究lincRNA在人體健康和疾病中的作用。
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