Multifunctional Gold Nanostars for Cancer Theranostics
暫譯: 多功能金納米星在癌症治療診斷中的應用

Liu, Yang

Multifunctional Gold Nanostars for Cancer Theranostics
  • 出版商: Springer
  • 出版日期: 2019-01-24
  • 售價: $4,950
  • 貴賓價: 9.5 折 $4,703
  • 語言: 英文
  • 頁數: 71
  • 裝訂: Quality Paper - also called trade paper
  • ISBN: 303009104X
  • ISBN-13: 9783030091040

    • 海外代購書籍(需單獨結帳)

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商品描述

This thesis presents the development of theranostic gold nanostars (GNS) for multimodality cancer imaging and therapy. Furthermore, it demonstrates that a novel two-pronged treatment, combining immune-checkpoint inhibition and GNS-mediated photothermal nanotherapy, can not only eradicate primary treated tumors but also trigger immune responses to treat distant untreated tumors in a mouse animal model.

Cancer has become a significant threat to human health with more than eight million deaths each year, and novel methods for cancer management to improve patients' overall survival are urgently needed. The developed multifunctional GNS nanoprobe with tip-enhanced plasmonics in the near-infrared region can be combined with (1) surface-enhanced Raman spectroscopy (SERS), (2) two-photon photoluminescence (TPL), (3) X-ray computed tomography (CT), (4) magnetic resonance imaging (MRI), (5) positron emission tomography (PET), and (6) photothermal therapy (PTT) for cancer imaging and treatment. The ability of the GNS nanoprobe to detect submillimeter intracranial brain tumors was demonstrated using PET scan - a superior non-invasive imaging modality - in a mouse animal model. In addition, delayed rechallenge with repeated cancer cell injection in cured mice did not lead to new tumor formation, indicating generation of a memorized immune response to cancer.

The biocompatible gold nanostars with superior capabilities for cancer imaging and treatment have great potential for translational medicine applications.

商品描述(中文翻譯)

這篇論文介紹了用於多模態癌症影像和治療的治療診斷金納米星（GNS）的開發。此外，它展示了一種新穎的雙重治療方法，結合了免疫檢查點抑制和GNS介導的光熱納米療法，不僅能消除主要治療的腫瘤，還能觸發免疫反應以治療小鼠動物模型中的遠端未治療腫瘤。

癌症已成為對人類健康的重大威脅，每年造成超過八百萬人死亡，迫切需要新穎的癌症管理方法以改善患者的整體生存率。所開發的多功能GNS納米探針在近紅外區域具有尖端增強的等離子體特性，可以與（1）表面增強拉曼光譜（SERS）、（2）雙光子光致發光（TPL）、（3）X射線計算機斷層掃描（CT）、（4）磁共振成像（MRI）、（5）正子發射斷層掃描（PET）和（6）光熱療法（PTT）結合，用於癌症影像和治療。GNS納米探針檢測亞毫米級顱內腦腫瘤的能力在小鼠動物模型中使用PET掃描進行了驗證，這是一種優越的非侵入性影像技術。此外，在治癒的小鼠中進行延遲重挑戰和重複癌細胞注射並未導致新腫瘤的形成，這表明對癌症產生了記憶免疫反應。

具有優越癌症影像和治療能力的生物相容性金納米星在轉化醫學應用中具有巨大的潛力。

作者簡介

Yang Liu obtained his bachelor's (2007) and master's degrees (2010) in Chemistry from Shanghai Jiao Tong University, China, where he studied molecular simulation in Dr. Huai Sun's lab between 2005 and 2010. After coming to Duke University, USA in 2010, he developed a multifunctional gold nanoprobe for sensitive cancer imaging and phototherapy. He has won several awards including a "Kathleen Zielek" fellowship and "Student Travel Award" to the SPIE conference. He received his master's degree in Biomedical Engineering in 2014 and Ph.D. degree in Chemistry in 2016 from Duke University. He is currently continuing his work on nanomedicine for cancer imaging and photoimmunotherpay as a postdoctoral research associate mentored by Dr. Tuan Vo-Dinh.

作者簡介(中文翻譯)

楊柳於2007年和2010年分別獲得中國上海交通大學的化學學士和碩士學位，期間在孫懷博士的實驗室進行分子模擬研究。2010年，他來到美國杜克大學，開發了一種多功能金納米探針，用於靈敏的癌症成像和光療法。他獲得了多項獎項，包括「Kathleen Zielek」獎學金和前往SPIE會議的「學生旅行獎」。他於2014年獲得生物醫學工程碩士學位，並於2016年獲得杜克大學的化學博士學位。目前，他在Tuan Vo-Dinh博士的指導下，作為博士後研究助理，繼續從事癌症成像和光免疫療法的納米醫學研究。

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