Essentials of Bioinformatics, Volume I: Understanding Bioinformatics: Genes to Proteins
暫譯: 生物資訊學基礎，第一卷：理解生物資訊學：從基因到蛋白質

生物資訊學是一個整合了計算機科學、遺傳學、基因組學、蛋白質組學和統計學的領域，無疑在過去幾十年中徹底改變了生物學和醫學的研究。它主要通過利用先進的計算方法來協助建模、預測和解釋大量的多維生物數據。儘管其潛力巨大，但生物資訊學並未廣泛融入學術課程，因為大多數生命科學的學生和研究人員仍然缺乏利用這一強大工具所需的知識。因此，我們這本書的主要目的是通過提供一個易於訪問的平台來補充這一未滿足的需求，幫助那些剛開始生命科學職業生涯的學生和研究人員。本書旨在避免複雜的計算算法和編程，而是主要專注於使用個人電腦進行簡單的DIY生物數據分析和解釋。我們相信，一旦初學者掌握了這些基本技能，他們將能夠處理大多數生物資訊學工具，以支持他們的研究工作並更好地理解實驗結果。

與其他大多數理論性的生物資訊學書籍不同，本書為讀者提供了使用最先進的開源工具解決生物問題的實用範例。書中包含實驗流程圖、圖形插圖和模擬數據，以便快速參考。因此，第一卷是希望掌握這一蓬勃發展領域的學生和早期專業人士的理想伴侶。

Noor Ahmad Shaik (PhD) is an academician, researcher and technologist working in the field Human Molecular Genetics. Over the last 15 years he has been working with different research groups whose fundamental focus is to offer genetic disease diagnostics, management and therapy. He is interested in discovering the novel causal genes/biomarkers for rare hereditary disorders and also to understand the effect of mutations on structure and function of causal proteins of human diseases. He has already published 42 research publications in reputed international journals of human genetics and bioinformatics. He is currently working to improve the current mutation prediction methods through integrative computational algorithms, so that clinicians and scientists can better understand the functional relevance of genetic mutations to disease. He has been a recipient of several research grants from national and international funding agencies. He is currently rendering his editorial services to world renowned journals like Frontiers in Pediatrics and Frontiers in Genetic Disorders.

Dr. Khalid Rehman Hakeem (PhD) is an Associate Professor at King Abdulaziz University, Jeddah, Saudi Arabia. He has completed his Ph.D. (Botany) from Jamia Hamdard, New Delhi, India in 2011. Dr. Hakeem has worked as Post Doctorate Fellow in 2012 and Fellow Researcher (Associate Prof.) from 2013-2016 at Universiti Putra Malaysia, Selangor, Malaysia.His speciality is Plant Eco-Physiology, Biotechnology & Molecular biology, Plant-Microbe-soil interactions and Environmental Sciences and so far has edited and authored more than 25 books with Springer International, Academic Press (Elsevier), CRC Press etc. He has also to his credit more than 120 research publications in peer reviewed international journals, including 42 book chapters in edited volumes with international publishers.

Dr. Babajan Banaganapalli (PhD) works as bioinformatics research faculty at King Abdulaziz University. He initiated and successfully running the interdisciplinary Bioinformatics program from 2014 to till-to date in King Abdulaziz University. He has more than 12 years of research experience in bioinformatics. His research interest spread across as genomics, proteomics and drug discovery for complex diseases. He published more than 40 journal articles, conferences papers and book chapters. He has also served in numerous conference program committees, organized several bioinformatics workshops, trainings programs and act as editor and reviewer for various international genetics/bioinformatics journals. Recently he was honored as young scientist for his outstanding research in bioinformatics by Venus International Research Foundation, India.
Dr. Ramu Elango (PhD) is a well experienced molecular geneticist and computational biologist with extensive experience at MIT, Cambridge, USA and GlaxoSmithKline R&D, UK, after completing his Ph.D. in Human Genetics at All India Institute of Medical Sciences, New Delhi, India. At GlaxoSmithKline, he contributed extensively in many disease areas of interest in identifying novel causal genes and tractable drug targets. Dr Ramu Elango presently heads the Research & Laboratories at the Princess Al-Jawhara Center of Excellence in Research of Hereditary Disorders, King Abdulaziz University. His research focus is on genetics and genomics of complex and polygenic diseases. His team exploits freely available large scale genetic and genomic data with bioinformatics tools to identify the risk factors or candidate causal genes for many complex diseases.

Noor Ahmad Shaik（博士）是一位學者、研究員和技術專家，專注於人類分子遺傳學領域。在過去的15年中，他與不同的研究團隊合作，這些團隊的基本重點是提供遺傳疾病的診斷、管理和治療。他對於發現罕見遺傳疾病的新致病基因/生物標記感興趣，並希望了解突變對人類疾病致病蛋白結構和功能的影響。他已在國際知名的人類遺傳學和生物資訊學期刊上發表了42篇研究論文。他目前正在通過整合計算算法來改進現有的突變預測方法，以便臨床醫生和科學家能更好地理解遺傳突變與疾病之間的功能相關性。他曾獲得多項來自國內外資助機構的研究資助，目前為《Frontiers in Pediatrics》和《Frontiers in Genetic Disorders》等世界知名期刊提供編輯服務。

Khalid Rehman Hakeem（博士）是沙烏地阿拉伯吉達的阿卜杜勒阿齊茲國王大學的副教授。他於2011年在印度新德里的Jamia Hamdard完成了植物學博士學位（Ph.D.）。Hakeem博士於2012年擔任博士後研究員，並於2013年至2016年在馬來西亞雪蘭莪的馬來亞大學擔任研究員（副教授）。他的專長包括植物生態生理學、生物技術與分子生物學、植物-微生物-土壤相互作用及環境科學，至今已編輯和撰寫超過25本與Springer International、Academic Press（Elsevier）、CRC Press等出版社合作的書籍。他在同行評審的國際期刊上發表了超過120篇研究論文，包括42篇國際出版社編輯卷中的書章。

Babajan Banaganapalli（博士）在阿卜杜勒阿齊茲國王大學擔任生物資訊學研究教職。他於2014年啟動並成功運行跨學科的生物資訊學計劃，至今仍在進行中。他在生物資訊學領域擁有超過12年的研究經驗。他的研究興趣涵蓋基因組學、蛋白質組學和複雜疾病的藥物發現。他已發表超過40篇期刊文章、會議論文和書章。他還在多個會議程序委員會中任職，組織了多個生物資訊學工作坊和培訓計劃，並擔任各種國際遺傳學/生物資訊學期刊的編輯和審稿人。最近，他因在生物資訊學領域的卓越研究而獲得印度Venus International Research Foundation的青年科學家榮譽。

Ramu Elango（博士）是一位經驗豐富的分子遺傳學家和計算生物學家，在美國麻省理工學院和英國葛蘭素史克研發部門擁有豐富的經驗，並在印度新德里的全印度醫學科學院完成了人類遺傳學博士學位（Ph.D.）。在葛蘭素史克，他在識別新致病基因和可行的藥物靶點方面對多個疾病領域做出了重要貢獻。Ramu Elango博士目前負責阿卜杜勒阿齊茲國王大學遺傳疾病研究卓越中心的研究與實驗室。他的研究重點是複雜和多基因疾病的遺傳學和基因組學。他的團隊利用自由可用的大規模遺傳和基因組數據，結合生物資訊學工具，識別許多複雜疾病的風險因素或候選致病基因。