Regulation of Gastrointestinal Mucosal Growth: Second Edition (Colloquium Series on Integrated Systems Physiology)
暫譯: 腸胃道黏膜生長的調控:第二版(綜合系統生理學研討會系列)

Rao N. Jaladanki, Jian-Ying Wang

  • 出版商: Morgan & Claypool
  • 出版日期: 2016-11-30
  • 售價: $1,760
  • 貴賓價: 9.5$1,672
  • 語言: 英文
  • 頁數: 146
  • 裝訂: Paperback
  • ISBN: 1615047344
  • ISBN-13: 9781615047345
  • 海外代購書籍(需單獨結帳)

商品描述

The mammalian gastrointestinal mucosa is a rapidly self-renewing tissue in the body, and its homeostasis is preserved through the strict regulation of epithelial cell proliferation, growth arrest, and apoptosis. The control of the growth of gastrointestinal mucosa is unique and, compared with most other tissue in the body, complex. Mucosal growth is regulated by the same hormones that alter metabolism in other tissues, but the gastrointestinal mucosa also responds to host events triggered by the ingestion and presence of food within the digestive tract. These gut hormones and peptides regulate the growth of the exocrine pancreas, gallbladder epithelium, and the mucosa of the oxyntic gland region of the stomach and the small and large intestines. Luminal factors, including nutrients or other dietary factors, secretions, and microbes that occur within the lumen and distribute over a proximal-to-distal gradient, are also crucial for maintenance of normal gut mucosal regeneration and could explain the villous-height-crypt-depth gradient and variety of adaptation, since these factors are diluted, absorbed, and destroyed as they pass down the digestive tract. Recently, intestinal stem cells, cellular polyamines, and noncoding RNAs are shown to play an important role in the regulation of gastrointestinal mucosal growth under physiological and various pathological conditions. In this book, we highlight key issues and factors that control gastrointestinal mucosal growth and homeostasis, with special emphasis on the mechanisms through which epithelial renewal and apoptosis are regulated at the cellular and molecular levels.

商品描述(中文翻譯)

哺乳動物的腸胃道黏膜是體內一種快速自我更新的組織,其穩態是通過對上皮細胞增殖、增長停滯和凋亡的嚴格調控來維持的。腸胃道黏膜的生長控制是獨特的,與體內大多數其他組織相比,這一過程更為複雜。黏膜的生長受到與其他組織代謝改變相同的激素調節,但腸胃道黏膜也會對由食物攝取和在消化道內存在所引發的宿主事件作出反應。這些腸道激素和肽類調節外分泌胰腺、膽囊上皮以及胃的氧化腺區域和小腸、大腸的黏膜生長。腔內因素,包括營養素或其他飲食因素、分泌物和微生物,這些因素在腔內發生並沿著近端到遠端的梯度分佈,對於維持正常的腸道黏膜再生至關重要,並且可以解釋絨毛高度與隱窩深度的梯度及其適應的多樣性,因為這些因素在通過消化道時會被稀釋、吸收和破壞。最近,腸道幹細胞、細胞多胺和非編碼RNA被證明在生理和各種病理條件下調節腸胃道黏膜生長中扮演重要角色。在本書中,我們強調控制腸胃道黏膜生長和穩態的關鍵問題和因素,特別強調在細胞和分子層面上調節上皮更新和凋亡的機制。