Genome-Scale Algorithm Design: Biological Sequence Analysis in the Era of High-Throughput Sequencing

Veli Mäkinen, Djamal Belazzougui, Fabio Cunial, Alexandru I. Tomescu

  • 出版商: Cambridge
  • 出版日期: 2015-06-24
  • 售價: $2,650
  • 貴賓價: 9.5$2,518
  • 語言: 英文
  • 頁數: 413
  • 裝訂: Hardcover
  • ISBN: 1107078539
  • ISBN-13: 9781107078536
  • 相關分類: Algorithms-data-structures
  • 海外代購書籍(需單獨結帳)

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商品描述

High-throughput sequencing has revolutionised the field of biological sequence analysis. Its application has enabled researchers to address important biological questions, often for the first time. This book provides an integrated presentation of the fundamental algorithms and data structures that power modern sequence analysis workflows. The topics covered range from the foundations of biological sequence analysis (alignments and hidden Markov models), to classical index structures (k-mer indexes, suffix arrays and suffix trees), Burrows-Wheeler indexes, graph algorithms and a number of advanced omics applications. The chapters feature numerous examples, algorithm visualisations, exercises and problems, each chosen to reflect the steps of large-scale sequencing projects, including read alignment, variant calling, haplotyping, fragment assembly, alignment-free genome comparison, transcript prediction and analysis of metagenomic samples. Each biological problem is accompanied by precise formulations, providing graduate students and researchers in bioinformatics and computer science with a powerful toolkit for the emerging applications of high-throughput sequencing.

商品描述(中文翻譯)

高通量測序已經徹底改變了生物序列分析的領域。其應用使研究人員能夠首次解決重要的生物學問題。本書提供了現代序列分析工作流程所需的基本演算法和資料結構的綜合介紹。涵蓋的主題從生物序列分析的基礎(比對和隱藏馬可夫模型),到經典索引結構(k-mer 索引、後綴陣列和後綴樹)、Burrows-Wheeler 索引、圖形演算法以及多個先進的組學應用。各章節包含大量範例、演算法視覺化、練習和問題,這些內容均選自大型測序專案的步驟,包括讀取比對、變異呼叫、單倍型分析、片段組裝、無比對基因組比較、轉錄預測及宏基因組樣本分析。每個生物學問題都附有精確的公式,為生物資訊學和計算機科學的研究生及研究人員提供了一套強大的工具,以應對高通量測序的新興應用。