Dental Pulp Derived Mesenchymal Stromal Cells
暫譯: 牙髓衍生間充質幹細胞

Sibel Yildirim is professor at the Faculty of Dentistry, Department of Pediatric Dentistry, Bilecik Seyh Edebali University, Bilecik, Turkey. She has been lecturer and practicing dentistry at the university for years. Her colleagues and she have established the first multi-disciplinary, dental/oral research centre in Turkey. She has authored many papers in international journals and has completed several research projects. Along with her pediatric dentistry PhD, she has also her second PhD on histology and embryology. Her research interests include many aspects of dental pulp and induced pluripotent stem cells, deciduous tooth resorption, the viral ethiopathogenesis of pulpal/periapical diseases of deciduous teeth and vital regenerative pulp therapies using recombinant human proteins or gene therapy. Accordingly, she has led some experiments on deciduous tooth pulp tissue and her team obtained important results showing high regulatory capacity of dental pulp cells on the events of deciduous tooth resorption or retention.

She had a change to study with the indisputable leaders in the dental engineering field in Japan, Switzerland and the United States. She has become an expert for stem cells from the pulp tissue of deciduous and permanent teeth. In addition to her dental tissue engineering studies, she has pursued re-programming experiments. She could observe that stem cells that have dental origin displayed strong potential for reprogramming. She believes comprehensively that isolating epithelial and mesenchymal stem cells from deciduous teeth and reprogramming them will point toward novel venues for in situ restoration of dental tissue repair. Currently her ongoing projects are focused on epigenetic regulations in dental pulp tissue.

As a pediatric dentist, histologist and embryologist, after long years of experience in academic fields in different continents, she has found herself that she became a student again who is keen to reach beyond the traditional boundaries of biology. She totally convinced that complexity is the only field that helps to achieve her goals; moving one step closer to understanding life.

Sibel Yildirim 是土耳其比萊吉克塞伊赫艾德巴利大學牙醫學院兒童牙醫學系的教授。她在大學擔任講師並從事牙科實踐多年。她和她的同事們建立了土耳其第一個多學科牙科/口腔研究中心。她在國際期刊上發表了許多論文，並完成了幾個研究項目。除了她的兒童牙醫學博士學位外，她還擁有一個有關組織學和胚胎學的博士學位。她的研究興趣包括牙髓和誘導多能幹細胞的許多方面、乳牙吸收、乳牙牙髓/根尖疾病的病毒病因學，以及使用重組人類蛋白質或基因治療的活性再生牙髓療法。因此，她主導了一些有關乳牙牙髓組織的實驗，她的團隊獲得了重要結果，顯示牙髓細胞在乳牙吸收或保留事件中的高調控能力。

她有機會與日本、瑞士和美國牙科工程領域的無可爭議的領導者學習。她已成為來自乳牙和恆牙牙髓組織的幹細胞專家。除了她的牙科組織工程研究外，她還進行了重新編程實驗。她觀察到來自牙科的幹細胞顯示出強大的重新編程潛力。她全面相信，從乳牙中分離上皮和間充質幹細胞並對其進行重新編程將指向牙科組織修復的原位重建的新途徑。目前，她正在進行的項目專注於牙髓組織中的表觀遺傳調控。

作為一名兒童牙醫、組織學家和胚胎學家，在不同大陸的學術領域經歷多年後，她發現自己再次成為一名學生，渴望超越生物學的傳統界限。她完全相信，複雜性是唯一能幫助她實現目標的領域；讓她更接近理解生命。