Brain-Bladder Axis in Tissue Growth and Remodelling
暫譯: 腦膀胱軸在組織生長與重塑中的作用
Miftahof, Professor Roustem, Böl Markus, Cyron, Christian
商品描述
Applying the general deterministic approach of systems computational biology, the monograph considers questions related to the biomechanics of the human urinary bladder in conjunction with the peripheral and central nervous systems. The step-by-step development of mathematical models of separate structural elements and their assembly into a unique self-regulatory system offers, for the first time, a holistic overview and allows the investigation of the dynamics of the lower urinary tract system at its hierarchical levels. This book provides a coherent description and explanation for intertwined intracellular pathways in terms of spatiotemporal, whole body, tractable representations which are supported by numerous computational simulations.
Key Features
- It reconstructs accurately the cytoarchitecture and morphofunctional relationships between the elements of the central nervous (brain) and genitourinary (urinary bladder system).
- Offers for the first time a both quantitative and qualitative, assessment of the neurohormonal and mechanobiological processes involved in the process.
- Provides a comprehensive description for intertwined regulatory pathways in terms of spatiotemporal dynamic representations.
- Encourages the reader to develop and apply a unique holistic approach to solving complex biomedical problems in the area of growth and remodeling of the urinary bladder through application of modern methods of computational biology.
商品描述(中文翻譯)
應用系統計算生物學的一般確定性方法,本專著考慮了與人類膀胱的生物力學以及周邊和中樞神經系統相關的問題。逐步發展的數學模型,針對各個結構元素及其組合成獨特的自我調節系統,首次提供了整體的概述,並允許在其層級上研究下尿路系統的動態。本書提供了一個連貫的描述和解釋,針對交織的細胞內途徑,從時空、全身和可處理的表徵進行說明,並得到眾多計算模擬的支持。
主要特點
- 準確重建中樞神經系統(大腦)和泌尿生殖系統(膀胱系統)元素之間的細胞結構和形態功能關係。
- 首次提供對參與該過程的神經激素和機械生物學過程的定量和定性評估。
- 提供交織調節途徑的全面描述,從時空動態表徵的角度進行說明。
- 鼓勵讀者發展並應用獨特的整體方法,通過應用現代計算生物學的方法來解決膀胱生長和重塑領域中的複雜生物醫學問題。