Hydrogen Peroxide Metabolism in Health and Disease
暫譯: 健康與疾病中的過氧化氫代謝

Vissers, Margreet C. M., Hampton, Mark, Kettle, Anthony J.

  • 出版商: CRC
  • 出版日期: 2020-09-30
  • 售價: $2,480
  • 貴賓價: 9.5$2,356
  • 語言: 英文
  • 頁數: 456
  • 裝訂: Quality Paper - also called trade paper
  • ISBN: 0367657589
  • ISBN-13: 9780367657581
  • 海外代購書籍(需單獨結帳)

相關主題

商品描述

Much of the biology of oxidative stress and oxidative signalling centres on the generation and handling of hydrogen peroxide. The overall aim for this book would be to provide an insightful and useful forum to assist with the understanding of the relevance of hydrogen peroxide generation and how this is managed in human biology. The target audience would be those who currently have an interest in the generation of ROS, but who do not have expertise in chemistry, as well as those experts in the chemistry of oxidative stress, but without detailed understanding of the biologically relevant setting. We would aim to bridge the gap in understanding between chemistry and biology.

商品描述(中文翻譯)

氧化壓力和氧化信號的生物學大部分集中在過氧化氫的生成和處理上。本書的整體目標是提供一個有見地且有用的論壇,以協助理解過氧化氫生成的相關性以及在人體生物學中如何管理這一過程。目標讀者包括目前對活性氧(ROS)生成感興趣但在化學方面沒有專業知識的人,以及在氧化壓力化學方面的專家,但對生物學相關背景缺乏詳細理解的人。我們的目標是彌合化學與生物學之間的理解差距。

作者簡介

University of Otago in Christchurch, New Zealand. She is also the Associate Dean of Research at the University of Otago. Her research is devoted to the role of reactive oxidants in biological systems, the consequences of their formation and the effects they initiate in cell signaling, as well as the protection offered by antioxidants. She is also interested in the ways in which neutrophils cause injury to cells and tissues in the process of acute inflammation and infection, and the contribution of neutrophil-derived oxidants and proteinases to the resulting pathology. A focus of this research has been the toxicity of hypochlorous acid (HOCl) and hypobromous acid (HOBr), major oxidants produced by neutrophils, and the effects of chloramines and bromamines which are derived from them. She has shown that these oxidants initiate cell stress signaling responses and death pathways including apoptosis. Vissers is the author or co-author of more than 100 peer reviewed journal articles, book chapters and coference proceedings. Mark Hampton and Tony Kettle are also both professors at University of Otago in Christchurch.

作者簡介(中文翻譯)

奧塔哥大學(University of Otago)位於紐西蘭基督城(Christchurch)。她同時也是奧塔哥大學的研究副院長。她的研究專注於反應性氧化劑在生物系統中的角色、其形成的後果以及它們在細胞信號傳遞中引發的影響,還有抗氧化劑所提供的保護。她也對中性粒細胞在急性發炎和感染過程中對細胞和組織造成損傷的方式感興趣,以及中性粒細胞衍生的氧化劑和蛋白酶對所產生病理的貢獻。這項研究的重點是次氯酸(hypochlorous acid, HOCl)和次溴酸(hypobromous acid, HOBr)的毒性,這些是中性粒細胞產生的主要氧化劑,以及由它們衍生的氯胺(chloramines)和溴胺(bromamines)的影響。她已經顯示這些氧化劑會啟動細胞壓力信號反應和死亡途徑,包括凋亡(apoptosis)。Vissers是超過100篇經過同行評審的期刊文章、書籍章節和會議論文的作者或合著者。Mark HamptonTony Kettle也都是奧塔哥大學的教授。

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