Carbohydrate Chemistry, Volume 2: Proven Synthetic Methods
暫譯: 碳水化合物化學，第2卷：已證實的合成方法
Van Der Marel, Gijsbert, Codee, Jeroen
- 出版商: CRC
- 出版日期: 2019-05-14
- 售價: $3,380
- 貴賓價: 9.5 折 $3,211
- 語言: 英文
- 頁數: 333
- 裝訂: Quality Paper - also called trade paper
- ISBN: 0367246848
- ISBN-13: 9780367246846
-
相關分類:
化學 Chemistry
海外代購書籍(需單獨結帳)
相關主題
商品描述
The second volume in the series Carbohydrate Chemistry: Proven Synthetic Methods, Volume 2 offers a collection of synthetic procedures valuable to the practice of synthetic carbohydrate chemistry. The series takes an important and unique approach in that all described procedures have been independently verified as reliable and reproducible. With editors and contributors who are highly respected scientists in the field, this book provides a widely useful reference for both researchers and students, exploring carbohydrate chemistry from both academic and industrial points of view.
The book begins with an introductory section that offers tricks and tips collected by the series editor from many years of experience working in carbohydrate laboratories. The subsequent chapters present detailed protocols on both specific synthetic transformations and the preparation of common synthetic intermediates, with figures to aid in comprehension. Procedures are described for regioselective benzylidene ring opening reactions, oxidation reactions to provide uronic acids, stereoselective alpha-glucosylation reactions, and more. Protocols for synthetic intermediates of general utility include 3,4,6-tri-O-acetyl-d-galactal, phenyl 4,6-O-benzylidene-1-thio-α-d-mannopyranoside, 1,2-anhydro-3,4,6-tri-O-benzyl-β-d-mannopyranoside, and methyl N-acetylneuraminic acid, among many others. Each chapter presents in-depth experimental descriptions for the reported procedures, including reaction setup, reaction conditions, work-up procedures, and purification protocols. The chapters also provide detailed characterization of all products and intermediates as well as copies of the 1H NMR and 13C NMR of the described products and intermediates to indicate the purity of the obtained materials and to serve as a valuable reference for future practitioners. This book provides an important starting point to reliably access synthetic carbohydrate materials and as such offers a valuable resource for the synthetic organic chemistry community. Through the streamlined access of well-defined products it provides a thrust to the rapidly growing field of chemical glycobiology.商品描述(中文翻譯)
第二卷的系列書籍碳水化合物化學：已證實的合成方法，第二卷提供了一系列對合成碳水化合物化學實踐有價值的合成程序。該系列採取了一種重要且獨特的方法，所有描述的程序均已獨立驗證為可靠且可重複。書籍的編輯和貢獻者都是該領域備受尊敬的科學家，為研究人員和學生提供了一個廣泛有用的參考，從學術和工業的角度探討碳水化合物化學。
本書以一個介紹部分開始，提供了系列編輯從多年在碳水化合物實驗室工作的經驗中收集的技巧和建議。隨後的章節詳細介紹了特定合成轉化和常見合成中間體的製備協議，並附有圖示以幫助理解。描述的程序包括區域選擇性苯基亞胺環開啟反應、氧化反應以提供尿酸、立體選擇性α-葡萄糖基化反應等。一般用途的合成中間體的協議包括3,4,6-三O-乙酰-d-半乳糖、苯基4,6-O-苯基亞胺-1-硫-α-d-甘露糖吡喃苷、1,2-脫水-3,4,6-三O-苯基-β-d-甘露糖吡喃苷和甲基N-乙酰神經氨酸等。
每章提供了所報告程序的深入實驗描述，包括反應設置、反應條件、後處理程序和純化協議。章節還提供了所有產品和中間體的詳細表徵，以及所描述產品和中間體的1H NMR和13C NMR的副本，以指示所獲材料的純度，並作為未來從業者的寶貴參考。
本書為可靠獲取合成碳水化合物材料提供了一個重要的起點，因此為合成有機化學社群提供了一個有價值的資源。通過對明確定義的產品的簡化訪問，它為快速增長的化學糖生物學領域提供了推動力。
作者簡介
Series Editor: Pavol Kováč, Ph.D., Dr. h.c., obtained his Ph.D. in organic chemistry at the Institute of Chemistry, Slovak Academy of Sciences, Bratislava. Dr. Kováč is a strong promoter of good laboratory practices and a vocal critic of the publication of experimental chemistry lacking data that allow reproducibility. He has more than 40 years of experience in carbohydrate chemistry and over 280 papers published in refereed scientific journals, several patents, and book chapters. He joined the National Institutes of Health (NIH) (Bethesda, Maryland) in 1983 where he is currently one of the principal investigators and chief of the Section on Carbohydrates (NIDDK, Laboratory of Bioorganic Chemistry). The world's oldest research group continuously working on chemistry, biochemistry, and immunology of carbohydrates, it was originally established by the American carbohydrate chemist Claude S. Hudson. Kováč's main interest is the development of conjugate vaccines for bacterial diseases from synthetic carbohydrate antigens.
Volume Two Editors:
作者簡介(中文翻譯)
系列編輯：
Pavol Kováč博士，榮譽博士，於斯洛伐克科學院化學研究所獲得有機化學博士學位。Kováč博士是良好實驗室實踐的強力推廣者，並且對缺乏可重複性數據的實驗化學出版物提出尖銳批評。他在碳水化合物化學領域擁有超過40年的經驗，並在經過審核的科學期刊上發表了超過280篇論文，擁有數項專利和書籍章節。他於1983年加入美國國立衛生研究院（NIH）（馬里蘭州貝塞斯達），目前是主要研究人員之一及碳水化合物部門（NIDDK，生物有機化學實驗室）的負責人。這是世界上最古老的持續從事碳水化合物化學、生物化學和免疫學研究的團隊，最初由美國碳水化合物化學家Claude S. Hudson創立。Kováč的主要興趣是從合成碳水化合物抗原開發針對細菌疾病的結合疫苗。
第二卷編輯：
Jeroen Codée於2004年在荷蘭萊頓大學獲得博士學位，指導教授為Jacques van Boom和Stan van Boeckel。Codée隨後前往瑞士蘇黎世的瑞士聯邦理工學院（ETH）進行為期兩年的博士後研究，指導教授為Peter Seeberger。之後，他回到萊頓大學，現在是生物有機化學的副教授。他的研究專注於糖化學和糖生物學，涵蓋從基礎有機合成到疫苗/藥物開發及糖生物學工具的開發。他已發表或共同發表超過70篇論文和七個書籍章節。
Gijs van der Marel在Jacques van Boom的指導下進行DNA化學的博士研究，並於1981年在荷蘭萊頓大學獲得博士學位。他一直與該大學保持聯繫，現在是合成有機化學的正教授。他指導了超過70名博士生，並發表或共同發表超過700篇論文。他的研究專注於生物聚合物的所有合成方面，包括核酸、肽和碳水化合物，以及其雜合物和類似物。
