Gene Regulation and Metabolism: Postgenomic Computational Approaches
暫譯: 基因調控與代謝：後基因組計算方法

Julio Collado-Vides , Ralf Hofestdt

Gene Regulation and Metabolism: Postgenomic Computational Approaches
  • 出版商: MIT
  • 出版日期: 2004-08-20
  • 售價: $1,050
  • 貴賓價: 9.8 折 $1,029
  • 語言: 英文
  • 頁數: 320
  • 裝訂: Paperback
  • ISBN: 0262532689
  • ISBN-13: 9780262532686

    • 下單後立即進貨 (約5~7天)

買這商品的人也買了...

商品描述

Description:

As exciting as the new field of genomics is, it has not yet produced a basic conceptual change in biology. The fundamental problems remain: the origin of life, cell organization, the pathways of differentiation, aging, and the molecular and cellular capabilities of the brain. What has occurred is an explosion of molecular information obtained by genomic sequences, which will soon be followed by exhaustive catalogs of protein interactions and protein function. This wealth of information can be analyzed and manipulated only with the help of computers. The rapidly expanding role of computers in biology may usher in a profound conceptual change in how we study living systems in the laboratory.

This book focuses on current computational approaches to understanding the complex networks of metabolic and gene regulatory capabilities of the cell. The contributors look well beyond the state of the art in computational biology to anticipate what biological research will be like in a post-genomic world.

Julio Collado-Vides is Professor and Head of the Laboratory of Computational Biology at the Universidad Nacional Autónoma de México, Cuernavaca. He is coeditor of Integrative Approaches to Molecular Biology (MIT Press, 1996).

Ralf Hofestädt is Professor of Bioinformatics and Medical Informatics at the University of Bielefeld.

 

Table of Contents:

Preface vii
1 Are the Eyes Homologous?
Jeremy C. Ahouse
 		 1
I Information and Knowledge Representation 17
2 Automation of Protein Sequence Characterization and Its Application in Whole Proteome Analysis
Rolf Apweiler, Margaret Biswas, Wolfgang Fleischmann, Evgenia V. Kriventseva and Nicola Mulder		 19
3 Information Fusion and Metabolic Network Control
Andreas Freier, Ralf Hofestädt, Matthias Lange and Uwe Scholz		 49
II Gene Regulation: From Sequence to Networks 85
4 Specificity of Protein-DNA Interactions
Gary D. Stormo		 87
5 Genomics of Gene Regulation: The View from Escherichia coli
Julio Collado-Vides, Gabriel Moreno-Hagelsieb, Ernesto Pérez-Rueda, Heladia Salgado, Araceli M. Huerta, Rosa Maria Gutiérrez, David A. Rosenblueth, Andrés Christen, Esperanza Benitez-Bellon, Arturo Medrano-Soto, Socorro Gama-Castro, Alberto Santos-Zavaleta, César Bonavides-Martinez, Edgar Diaz-Peredo, Fabiola Sanchez-Solano and Dulce Maria Millan		 103
6 Discovery of DNA Regulatory Motifs
Abigail Manson McGuire and George M. Church		 129
7 Gene Networks Description and Modeling in the GeneNet System
Nikolay A. Kolchanov, Elena A. Ananko, Vitali A. Likhoshvai, Olga A. Podkolodnaya, Elena V. Ignatieva, Alexander V. Ratushny and Yuri G. Matushkin		 149
8 Regulation of Cellular States in Mammalian Cells from a Genomewide View
Sui Huang		 181
III Postgenomic Approaches 221
9 Predicting Protein Function and Networks on a Genomewide Scale
Edward M. Marcotte		 223
10 Metabolic Pathways
Steffen Schmidt and Thomas Dandekar		 251
11 Toward Computer Simulation of the Whole Cell
Masaru Tomita		 273
Glossary 289
Corresponding Authors 297
Index
 		 299

商品描述(中文翻譯)

描述：
儘管基因組學這一新領域令人興奮，但它尚未在生物學上產生根本性的概念變化。基本問題依然存在：生命的起源、細胞組織、分化的途徑、衰老，以及大腦的分子和細胞能力。所發生的是通過基因組序列獲得的分子信息的爆炸，隨之而來的將是蛋白質相互作用和蛋白質功能的詳細目錄。這些豐富的信息只能在計算機的幫助下進行分析和操作。計算機在生物學中迅速擴大的角色可能會引領我們在實驗室中研究生命系統的方式發生深刻的概念變化。

本書專注於當前計算方法，以理解細胞的代謝和基因調控能力的複雜網絡。貢獻者們超越了計算生物學的最新技術，預測在後基因組時代生物研究將會是什麼樣子。

Julio Collado-Vides是墨西哥國立自治大學庫埃納瓦卡計算生物學實驗室的教授和主任。他是《Integrative Approaches to Molecular Biology》（MIT Press, 1996）的共同編輯。

Ralf Hofestädt是比勒費爾德大學的生物信息學和醫學信息學教授。

目錄：
前言
1. 眼睛是同源的嗎？ - Jeremy C. Ahouse
I. 信息與知識表示
2. 蛋白質序列特徵化的自動化及其在全蛋白質組分析中的應用 - Rolf Apweiler, Margaret Biswas, Wolfgang Fleischmann, Evgenia V. Kriventseva 和 Nicola Mulder
3. 信息融合與代謝網絡控制 - Andreas Freier, Ralf Hofestädt, Matthias Lange 和 Uwe Scholz
II. 基因調控：從序列到網絡
4. 蛋白質-DNA相互作用的特異性 - Gary D. Stormo
5. 基因調控的基因組學：來自《大腸桿菌》的視角 - Julio Collado-Vides, Gabriel Moreno-Hagelsieb, Ernesto Pérez-Rueda, Heladia Salgado, Araceli M. Huerta, Rosa Maria Gutiérrez, David A. Rosenblueth, Andrés Christen, Esperanza Benitez-Bellon, Arturo Medrano-Soto, Socorro Gama-Castro, Alberto Santos-Zavaleta, César Bonavides-Martinez, Edgar Diaz-Peredo, Fabiola Sanchez-Solano 和 Dulce Maria Millan
6. DNA調控基序的發現 - Abigail Manson McGuire 和 George M. Church
7. GeneNet系統中的基因網絡描述與建模 - Nikolay A. Kolchanov, Elena A. Ananko, Vitali A. Likhoshvai, Olga A. Podkolodnaya, Elena V. Ignatieva, Alexander V. Ratushny 和 Yuri G. Matushkin
8. 從全基因組視角看哺乳動物細胞的狀態調控 - Sui Huang
III. 後基因組方法
9. 在全基因組範圍內預測蛋白質功能和網絡 - Edward M. Marcotte
10. 代謝途徑 - Steffen Schmidt 和 Thomas Dandekar
11. 朝向整個細胞的計算機模擬 - Masaru Tomita
術語表
通訊作者
索引

類似商品