Ion Channels: Channel Chemical Biology, Engineering, and Physiological Function, 654
暫譯: 離子通道:通道化學生物學、工程與生理功能
Minor, Daniel L., Colecraft, Henry M.
- 出版商: Academic Press
- 出版日期: 2021-06-15
- 售價: $7,140
- 貴賓價: 9.5 折 $6,783
- 語言: 英文
- 頁數: 454
- 裝訂: Hardcover - also called cloth, retail trade, or trade
- ISBN: 0128239247
- ISBN-13: 9780128239247
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商品描述
Ion Channels, Part C, Volume 653 in the Methods in Enzymology series, highlights new advances in the field with this new volume presenting interesting chapters on a variety of topics, including Nonsense suppression in ion channels, Engineering Ion Channels Using Protein Trans-splicing, Probing Ion Channel Neighborhoods Using APEX, STX based probes for NaVs, ANAP: a versatile, fluorescent probe of ion channel gating and regulation, High Throughput Screens for Small Molecule Ion Channel Modulators, Using toxins to study ion channels, Re/de-constructing ubiquitin regulation of ion channels, Tethered Peptide Toxins for Ion Channels, Voltage-Sensing Phosphatase Molecular Engineering, and more.
Additional chapters cover Engineering excitable cells, Stretch and Poke Stimulation of Mechanically-Activated Ion Channels, Optical Control of STIM Channels, High Throughput Electrophysiological Evaluation of Mutant Ion Channels, Evaluating BEST1 Mutations in RPE Stem Cells, Long Read Transcript Profiling of Ion Channel Splice Variants, Permeation of Connexin Channels, Ratiometric pH indicator for melanosomes and lysosomes, and Ion channels in the epithelial cells of the choroid plexus.
商品描述(中文翻譯)
《離子通道,C部分,方法在酶學系列中的第653卷》突顯了該領域的新進展,這本新卷呈現了有趣的章節,涵蓋多種主題,包括離子通道中的無義抑制、利用蛋白質轉接合成工程化離子通道、使用APEX探測離子通道鄰域、基於STX的鈉通道探針、ANAP:一種多功能的螢光探針用於離子通道的閘控和調節、高通量篩選小分子離子通道調節劑、利用毒素研究離子通道、重建/解構泛素對離子通道的調控、用於離子通道的固定肽毒素、電壓感應磷酸酶的分子工程等。
其他章節涵蓋了可激發細胞的工程、機械激活離子通道的拉伸和戳刺刺激、STIM通道的光學控制、高通量電生理評估突變離子通道、評估RPE幹細胞中的BEST1突變、離子通道剪接變體的長讀取轉錄組分析、連接蛋白通道的通透性、用於黑色素體和溶酶體的比率pH指示劑,以及脈絡叢上皮細胞中的離子通道。